MIT/Harvard Center for Magnetic Resonance

麻省理工学院/哈佛大学磁共振中心

基本信息

批准号：
10224248
负责人：
ROBERT Guy GRIFFIN
金额：
$ 104.43万
依托单位：
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-06-01 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10224248
关键词：
2,4-Dinitrophenol 3-Dimensional Agreement Binding Caliber Cholesterol Communities Core Protein Crystallization Development Diamond Disease Ensure Equipment Evolution Frequencies Funding G-Protein-Coupled Receptors Grant Helium Investigation Isotope Labeling Label Laboratories Libraries Magic Magnetic Resonance Magnetic Resonance Spectroscopy Measures Membrane Proteins Methods Molecular Morphologic artifacts Motion Nature Nuclear Nucleic Acids Pharmacologic Substance Physiologic pulse Procedures Production Protein Dynamics Proteins Request for Proposals Research Resolution Sampling Schedule Seeds Side Signal Transduction Site Structure System Techniques Technology Temperature Tertiary Protein Structure Thermal Conductivity Time Tyrosine Vertebral column base biological systems cohort cost cryogenics design dipole moment experimental study improved instrument instrumentation magnetic dipole magnetic field microwave electromagnetic radiation next generation optimal control theory protein function protein structure structural biology theories transmission process

项目摘要

Project Summary Overall The Overall section of the P41 presents a summary of the four TR&D projects which are part of the proposal. These include TR&D 1 – New instrumentation for magnetic resonance TR&D 2 – High-field and fast-MAS methods for biomolecular structure and dynamics TR&D 3 – Next generation solution NMR methods TR&D 4 -- Advanced Magic Angle Spinning NMR methods The specific aims of each of these projects is described and a summary of the contents in presented in more detail. In addition, we provide a rationale for the P41 center which includes the cost and size of present day instrumentation, the unique requirements for instruments and the sophistication of magnetic resonance spectroscopy. We also provide a table enumerating the equipment presently available for the CMR and a list of the new instrumentation that will be constructed during the five years of the proposed grant.

项目概要全面的 P41 的总体部分总结了四个 TR&D 项目，它们是提案的一部分。 TR&D 1 – 新型磁共振仪器 TR&D 2 – 用于生物分子结构和动力学的高场和快速 MAS 方法 TR&D 3 – 下一代解决方案 NMR 方法 TR&D 4——先进的魔角旋转核磁共振方法描述了每个项目的具体目标并总结了内容更详细地介绍了。此外，我们还提供了 P41 中心的基本原理，其中包括成本和规模当今的仪器仪表、对仪器的独特要求和复杂性磁共振波谱。我们还提供了一个表格，列出了目前可用于 CMR 的设备和将在拟议的五年内建造的新仪器清单授予。