Enhancements to the SPF Colony to Increase Production and Efficiency in Management

增强 SPF 群体以提高产量和管理效率

• 批准号: 10405992
• 负责人: Joyce Kimberly Cohen
• 金额: $ 40.84万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-03 至 2022-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10405992
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adult; Animal Model; Animals; Breeding; Custom; Ensure; Female; Funding; Genetic Variation; Goals; Grant; Growth; HIV Infections; Health Surveys; Human Resources; Individual; Location; Macaca mulatta; Modeling; Monoclonal Antibody R24; Parents; Periodicity; Population; Primates; Procedures; Process; Production; Research; Research Project Grants; Resources; Risk; Scientist; Sex Ratio; Speed; Surveys; Testing; Time; United States National Institutes of Health; Women' s Group; genetic pedigree; germ free condition; improved; male; nonhuman primate; novel; parent grant; preclinical study; prevent; programs; restraint; success; therapy development

Project Summary/ Abstract The AIDS research portfolio at Yerkes National Primate Research Center (YNPRC) has continued to expand as demonstrated by a peak growth of approximately $6.5 million dollars (30% increase) in nonhuman primate (NHP) AIDS research grant funding over the past eight years. This growth in grant funding is accompanied by a high demand for Indian-origin specific pathogen free (SPF) rhesus macaques as the animal model for this research. YNPRC has continued to maintain a colony of SPF rhesus macaques under the parent grant (U42 OD011023) to provide these animals for HIV/AIDS research. This supplement application titled “Enhancements to the SPF Colony to Increase Production and Efficiency in Management” requests support for (1) the addition of novel “introduction enclosures” to select U42 supported compounds in the SPF colony that will ultimately increase production in the breeding colony and (2) the acquisition of a mobile procedure room and new capture tunnels that improve the efficiency of annual animal examinations and SPF testing of the colony. The goals of this supplement proposal will facilitate enhancements to the management and husbandry core in the parent U42 grant. The goals of the husbandry and management core are to leverage the resources provided by the U42 to maximize production of Indian-origin rhesus monkeys and facilitate allocation of these animals for NIH-funded HIV/AIDS research. This supplemental application will contribute to these goals with the following two specific aims: (1) to build additional introduction enclosures to improve the success of the introduction of multiple breeder males to female groups, thereby improving adult sex ratios and animal production and (2) to acquire a veterinary trailer and restraint capture tunnels to improve the efficiency of annual health surveys performed on the SPF colony at the Field Station Achieving these aims will help increase production and enhance management of the Yerkes U42 supported SPF breeding colony to ensure the program is sustainable, providing the necessary animals to support the HIV/AIDS research program using Indian-origin rhesus monkeys. The availability of this critical resource to scientists performing preclinical studies using the rhesus monkey model will have a positive, significant impact on the development of treatments to prevent or cure infection from HIV in people.

项目概要/摘要 耶基斯国家灵长类研究中心 (YNPRC) 的艾滋病研究组合不断扩大 非人类灵长类动物的峰值增长约为 650 万美元（增长 30%） (NHP) 过去八年的艾滋病研究补助资金伴随着补助资金的增长。 对印度原产无特定病原体 (SPF) 恒河猴作为该研究动物模型的需求量很大 YNPRC 在家长资助下继续维持 SPF 恒河猴群体（U42）。 OD011023）为艾滋病毒/艾滋病研究提供这些动物本补充申请标题为“增强”。 向 SPF 群体提高产量和管理效率”请求支持 (1) 添加 的新颖“引入外壳”，以在 SPF 菌落中选择 U42 支持的化合物，最终将 增加繁殖群的产量以及 (2) 购买移动手术室和新的捕获 隧道可提高年度动物检查和群体 SPF 测试的效率。 该补充提案的目标将促进加强管理和畜牧核心 母公司 U42 补助金的目标是利用资源。 由 U42 提供，以最大限度地提高印度恒河猴的产量并促进这些猴子的分配 该补充应用程序将有助于实现这些目标。 以下两个具体目标： (1) 建造额外的引入围栏以提高 将多个繁殖雄性引入雌性群体，从而改善成年性别比和动物 (2) 购买兽医拖车和约束捕获隧道，以提高生产效率 在野外站对 SPF 群体进行年度健康调查 实现这些目标将有助于增加 Yerkes U42 支持的产量并加强管理 SPF 繁殖群，确保该计划可持续发展，提供必要的动物来支持 使用印度恒河猴进行艾滋病毒/艾滋病研究计划 这一重要资源的可用性。 科学家使用恒河猴模型进行临床前研究将产生积极、重大的影响 开发预防或治愈人类艾滋病毒感染的治疗方法。