Children's National Hospital Site Consortium - Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Operations and Collaborations Center (UM2 Clinical Trial Optional)

国家儿童医院基地联盟 - HIV/艾滋病干预青少年医学试验网络 (ATN) 运营和合作中心（UM2 临床试验可选）

• 批准号: 10599559
• 负责人: Natella Yurievna Rakhmanina
• 金额: $ 33.5万
• 依托单位: WESTAT, INC.
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-22 至 2029-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10599559
• 关键词: AIDS prevention; AIDS/HIV problem; Academy; Acquired Immunodeficiency Syndrome; Adolescent; Adolescent Medicine Trials Network; Adolescent and Young Adult; Adult; American; Area; Assessment tool; Behavioral Sciences; Black race; Capital; Caring; Child; Childhood; Chlamydia; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Cohort Studies; Collaborations; Communities; Counseling; County; Data; Development; District of Columbia; Enrollment; Ensure; Epidemic; European; Funding; Goals; Gonorrhea; Guidelines; HIV; HIV Infections; HIV diagnosis; HIV prevention trial; HIV-infected adolescents; Health; Health Services Accessibility; Hospitals; Hotlines; Human immunodeficiency virus test; Incidence; Industry; Infection; International Maternal Pediatric Adolescent AIDS Clinical Trials; Intervention; Intervention Studies; Investigational Drugs; Laboratories; Leadership; Maryland; Methodology; Minority; Modeling; National Children' s Study; Outcome; Participant; Pediatric HIV/AIDS Cohort Study; Pediatrics; Pharmacy facility; Physicians; Positioning Attribute; Prevalence; Prevention; Productivity; Psychosocial Assessment and Care; Public Health; Publishing; Readiness; Recording of previous events; Research; Research Personnel; Risk; Role; Schools; Sexually Transmitted Diseases; Site; Social Sciences; Teletherapy; United States; United States Dept. of Health and Human Services; United States National Institutes of Health; Washington; age group; aged; antiretroviral therapy; base; care systems; clinical center; community engagement; cooking; high school; implementation science; innovation; metropolitan; novel; operation; pediatric human immunodeficiency virus; peer support; pre-exposure prophylaxis; prevent; prevention service; programs; recruit; screening; testing services; tool; treatment services

ABSTRACT Children's National Hospital (CNH) CRS Despite the substantial progress in the HIV epidemic, adolescents, and young adults (AYA) aged 13-24 years living with HIV have worse health outcomes compared to any other age groups in the United States (US). Children's National Hospital (CNH), provides comprehensive HIV prevention and treatment services to the majority of AYA from the District of Columbia (DC) eligible metropolitan area (EMA) including three national HIV epidemic hotspots—Washington, DC, and two Maryland counties (Montgomery and Prince George's). Within DC, which continues to have the highest rates of new HIV infection in the United States, AYA have a high HIV prevalence of 0.3%, and high incidence of sexually transmitted infections, placing them at substantial risk for acquiring HIV. Through universal HIV counselling and opt-out screening, CNH reaches out to thousands of AYA in the DC EMA yearly with HIV prevention and testing services. Currently ~300 primarily minority Black AYA are in care at CNH for pre-exposure prophylaxis and antiretroviral treatment. CNH has a longstanding history of collaboration within local, regional, and national scientific networks, including prior participation in the Adolescent Trials Network (ATN). CNH has served as a successful recruitment site to multiple industry-sponsored investigational new drug clinical trials and received an uninterrupted line of DC Department of Health funding for HIV prevention and testing for more than 10 years. CNH has well-established partnerships with local and regional community-based organizations and a strong track-record of leadership in AYA HIV research within the broader local community of academic and community-based investigators, including its active role in DC Center for AIDS Research and DC Cohort Study. The overarching goal of the proposed ATN CNH consortium site is to contribute to the Westat-led ATN Operation and Collaboration Center (OCC) long-term scientific impact while expanding its role in delivering direct public health impacts on the local, regional, and national HIV epidemic among AYA. To achieve this goal, CNH will: (a) actively participate in the development and implementation of the Westat-led ATN OCC clinical trials identified by the ATN Executive and Scientific Leadership Committees; (b) deliver innovative solutions to optimize recruitment, enrollment, and retention of AYA at multiple sites in the DC EMA in ATN studies and ensure local laboratory capacity and pharmacy support; (c) propose novel concepts, approaches, and methodologies in implementation and clinical science, and development and optimization of biomedical prevention and treatment tools for AYA; and (d) meaningfully contribute to the Westat-led ATN OCC leadership model through sustained CNH site and AYA community engagement, expanding network collaborations through established regional collaborations among clinical, academic, community-based AYA focused partners, local DOHs, and schools. By participating in the Westat-led ATN OCC, CNH is uniquely positioned to contribute to advancing the National HIV/AIDS Strategy and the national plan of Ending the HIV Epidemic in the United States.

摘要儿童国家医院（CNH）CRS 尽管艾滋病毒流行，青少年和年轻人（aya），但年龄13-24岁 与美国的任何其他年龄段相比，患有艾滋病毒的健康状况较差。 儿童国家医院（CNH），为综合的艾滋病毒预防和治疗服务 来自哥伦比亚特区（DC）合格大都市地区（EMA）的大多数AYA，包括三个国家 艾滋病毒流行热点 - 华盛顿特区和两个马里兰州县（蒙哥马利和乔治王子）。 在DC内，美国的新艾滋病毒感染率仍然最高，AYA有A 高艾滋病毒患病率为0.3％，性传播感染的高事件，将其置于实质性 获取艾滋病毒的风险。通过通用的艾滋病毒咨询和选择退出筛查，CNH与 DC EMA年度成千上万的AYA每年通过HIV预防和测试服务。目前〜300主要 少数黑Aya在CNH接受预防前的预防和抗逆转录病毒治疗。 CNH有一个 在本地，地区和国家科学网络内的合作历史，包括先验 参与青少年试验网络（ATN）。 CNH已成为成功的招聘网站 多个行业赞助的研究新药临床试验，并获得了不间断的DC系列 预防艾滋病毒和测试的卫生资金已有10年以上。 CNH已经建立了良好的 与地方和地区社区的组织建立合作伙伴关系，并在 AYA HIV在更广泛的学术和社区调查员社区中的研究， 包括其在DC AIDS研究中心和DC队列研究中的积极作用。总体目标 拟议的ATN CNH联盟网站将为Westet领导的ATN运营与合作中心做出贡献 （OCC）长期科学影响，同时扩大其在对当地的直接公共卫生影响方面的作用， AYA中的区域和全国艾滋病毒流行。为了实现这一目标，CNH将：（a）积极参与 ATN高管确定的Westet领导的ATN OCC临床试验的开发和实施 和科学领导委员会； （b）提供创新的解决方案，以优化招聘，入学和 在ATN研究中，在DC EMA的多个地点保留AYA，并确保地方实验室的能力和 药房支持； （c）提议实施和临床方面的新颖概念，方法和方法 AYA生物医学预防和治疗工具的科学，开发和优化；和 （d）通过持续的CNH网站和AYA有意义地为Westet领导的ATN OCC领导模型做出了贡献 社区参与，通过既定的区域合作来扩大网络合作 临床，学术，基于社区的AYA集中伙伴，本地DOH和学校。通过参加 由Westat领导的ATN OCC，CNH具有独特的位置，有助于推进国家艾滋病毒/艾滋病战略 以及结束美国艾滋病毒流行的国家计划。