Enhancing basic and translational TB research in northern Vietnam

加强越南北部的基础和转化结核病研究

• 批准号: 10115836
• 负责人: Brian Thacher Murphy
• 金额: $ 21.59万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10115836
• 关键词: AIDS/HIV problem; Academy; Antibiotics; Basic Science; Biochemistry; Biodiversity; Biological Assay; Centers for Disease Control and Prevention (U.S.); Cessation of life; Chicago; Clinical; Collaborations; Complement; Country; Development; Disease; Drug resistance in tuberculosis; Epidemiology; Foundations; Funding; HIV Seropositivity; Hygiene; Illinois; In Vitro; Infrastructure; Institutes; Institution; Lead; Medical; Mycobacterium tuberculosis; Natural Resources; Pathogenicity; Pharmaceutical Preparations; Plants; Research; Research Infrastructure; Research Personnel; Research Training; Resources; Science; Scientist; Students; System; Technology; Training; Training Programs; Training and Education; Translational Research; Tuberculosis; United States National Institutes of Health; Universities; Vietnam; Work; World Health Organization; base; post-doctoral training; pre-doctoral; programs; screening; screening program; success; AIDS/HIV problem; Academy; Antibiotics; Basic Science; Biochemistry; Biodiversity; Biological Assay; Centers for Disease Control and Prevention (U.S.); Cessation of life; Chicago; Clinical; Collaborations; Complement; Country; Development; Disease; Drug resistance in tuberculosis; Epidemiology; Foundations; Funding; HIV Seropositivity; Hygiene; Illinois; In Vitro; Infrastructure; Institutes; Institution; Lead; Medical; Mycobacterium tuberculosis; Natural Resources; Pathogenicity; Pharmaceutical Preparations; Plants; Research; Research Infrastructure; Research Personnel; Research Training; Resources; Science; Scientist; Students; System; Technology; Training; Training Programs; Training and Education; Translational Research; Tuberculosis; United States National Institutes of Health; Universities; Vietnam; Work; World Health Organization; base; post-doctoral training; pre-doctoral; programs; screening; screening program; success

In 2014, the World Health Organization estimated that there were 1.5 million deaths as a result of Mycobacterium tuberculosis (TB) infection (0.4 million of which were HIV-positive). Vietnam is located in a region that accounts for 58% of the world's TB cases, and an estimated 137,000 Vietnamese are infected with TB per year (5,000 of which acquire drug-resistant TB). Of these, the disease kills an estimated 19,000 Vietnamese annually. In the current proposal, we aim to enhance and strengthen a research training program between the University of Illinois at Chicago (UIC), the Institute of Marine Biochemistry at the Vietnam Academy of Science and Technology (IMBC-VAST), and the National Institute of Hygiene and Epidemiology (NIHE) in Hanoi, Vietnam. We aim to enhance host country basic and translational research capacity that focuses on the discovery and development of antibiotic leads for TB. Since the 1990s, the Centers for Disease Control and Prevention have invested heavily in both clinical labs and HIV/AIDS/TB surveillance systems in Vietnam, though these and several other efforts have focused predominantly on building medical infrastructure. Our proposal will bridge this gap by enhancing basic and translational science research infrastructure and a researcher training program that focuses on utilizing host-country resources to discover antibiotic leads that will treat TB and probe its basic mechanisms of pathogenicity through coordinated antibiotic lead screening programs in Hanoi. The success of this program is driven by short- and long-term research training and education. UIC has a strong track record of collaboration with VAST. Through NIH and MacArthur Foundation funding in the past 20 years, the team has worked to build a plant-based drug-lead discovery and resource conservation program. However, with greater than 3,000 km of coastline, Vietnam harbors some of the richest marine biodiversity in the world, from which this proposal aims to mine. The aims of this program are 1) Establish three independent investigators at IMBC-VAST/NIHE via long-term postdoctoral training at UIC; 2) Provide short- and long-term antibiotic-specific training to nine IMBC/NIHE predoctoral students over the course of the program period; 3) Enhance biological assay research infrastructure through creation of an in vitro M. tuberculosis screening program at NIHE. In a five-year period, our program will generate twelve highly trained scientists who specialize in TB antibiotic discovery and development. Three of the twelve scientists – with considerable institutional support from the Director and President of their respective institutes – will establish independent research groups that complement a broader program that uses Vietnam's natural resources to discover TB antibiotics, and to use these leads to explore mechanisms of M. tuberculosis pathogenicity. Beyond the five-year project period, the significant enhancement in research capacity at IMBC and NIHE will establish northern Vietnam as a translational screening center for TB, and will facilitate collaboration with institutions across and outside Vietnam.

2014年，世界卫生组织估计，结核分枝杆菌（TB）感染（其中40万例HIV阳性）导致150万人死亡。越南位于一个占世界结核病病例的58％的地区，估计每年有137,000名越南人感染了结核病（其中5,000人获得了耐药性结核病）。其中，该疾病每年丧生约19,000个越南人。在当前的提案中，我们旨在加强和加强伊利诺伊大学芝加哥大学（UIC），越南科学技术学院（IMBC-VAST）的海洋生物化学研究所（UIC）之间的研究培训计划，以及北诺（Hanoi），Vietnam，Vietnam，Hanoi的国立卫生研究所和卫生研究所和流行病学学院（NIHE）。我们旨在增强东道国基本和翻译的研究能力，重点是发现和开发结核病的抗生素铅。自1990年代以来，越南疾病控制与预防中心已经在临床实验室和艾滋病毒/艾滋病/结核病监视系统上进行了大量投资，尽管这些和其他几项努力主要集中在建设医疗基础设施上。我们的建议将通过增强基本和翻译的科学研究基础设施和研究人员培训计划来弥合这一差距，该计划专注于UIC，具有与VAST的合作良好的记录。通过NIH和MacArthur基金会在过去20年中的资金，该团队致力于建立一个基于植物的毒品铅发现和资源保护计划。但是，越南拥有超过3,000公里的海岸线，拥有世界上一些最富有的海洋生物多样性，该提议的目的是从中开采。该计划的目的是1）通过UIC的长期博士后培训在IMBC-VAST/NIHE建立三名独立研究人员； 2）在课程期间，为9个IMBC/NIHE前学生提供短期和长期抗生素的培训； 3）通过在NIHE创建一项体外结核病筛查程序来增强生物评估研究基础设施。在五年的时间里，我们的计划将产生十二位训练有素的科学家，专门研究结核病抗生素发现和开发。十二位科学家中有三位（在其各自机构的董事兼总裁兼董事的机构支持下）将建立独立的研究小组，以补充更广泛的计划，该计划使用越南的自然资源发现结核病抗生素，并利用这些铅来探索结核分枝杆菌致病性的机制。除了五年期，IMBC和NIHE的研究能力的显着提高将建立越南北部，成为TB的翻译筛查中心，并有助于与越南和越南以外的机构合作。