Puerto Rico Testsite for Exploring Contamination Threats (PROTECT)

波多黎各探索污染威胁的试验场（PROTECT）

• 批准号: 10382024
• 负责人: Akram N Alshawabkeh
• 金额: $ 1.51万
• 依托单位: NORTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-21 至 2022-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10382024
• 关键词: Address; Affect; Air; Biological Markers; Birth; Blood; Chemical Exposure; Chemicals; Cohort Studies; Development; Dust; Environment; Environmental Pollutants; Fire - disasters; Flame Retardants; Growth; Length; Link; Maternal and Child Health; Measures; Mediation; Nature; New Hampshire; Organophosphates; Outcome; Oxidative Stress; Phase; Pregnancy; Pregnant Women; Production; Puerto Rico; Sampling; Scheme; Silicones; Spontaneous abortion; Urine; Vascular Diseases; adverse pregnancy outcome; novel strategies; phthalates; pollutant; polybrominated diphenyl ether; pregnancy disorder; prevent; reproductive system disorder; subfertility

Project Description (Abstract) Flame retardants are chemicals that are applied to materials to prevent the start or slow the growth of fire. Although some of these chemicals, such as polybrominated diphenyl ethers (PBDE’s) have been phased out of production, they remain persistent in the environment. PBDEs do not chemically bind to the products to which they are added, so they easily release from these products and get into the air and dust. Although PBDEs have been phased out of production, some organophosphate flame retardants (OPRFs) and other alternatives have been identified as replacements. Due to this, there is a growing concern on flame retardants and how they can affect maternal and child health during pregnancy. Studies on the effects of flame retardants and birth outcomes are mixed. Flame retardants and other pollutant biomarkers are usually measured through blood and urine samples during pregnancy. This sampling scheme is limited in detecting other persistent environmental pollutants that may also be relevant exposures. To address this limitation, the development of silicone wristbands is a novel approach to measure multipollutant exposures because of its non-invasive and minimally burdensome nature, particularly for pregnant women. Oxidative stress has been implicated in many reproductive and pregnancy disorders, from subfertility to miscarriage, maternal vascular disease and preterm birth4. It has been suggested as a mechanism linking chemical exposure and adverse pregnancy outcomes. To this end, the proposed project will examine the relationship between flame retardants and phthalate biomarkers measured by silicone wristbands and their associations to gestational length and birthweight. It will also be an exploratory analysis of the potential mediation of oxidative stress on this relationship using the New Hampshire Birth Cohort study.

项目描述（摘要） 阻燃剂是适用于材料的化学物质，以防止开始或减慢生长的生长 尽管其中一些化学物质，例如多溴二苯基醚（PBDE） 退出生产，它们在环境中仍然持久。 PBDE不会化学与产品结合到 它们被添加了，因此它们很容易从这些产品中释放出来并进入空气和灰尘。虽然PBDES 已经逐步淘汰生产，一些有机磷酸盐阻燃剂（OPRF）和其他替代品 已被确定为替代品。因此，人们对阻燃剂及其如何越来越关注 在怀孕期间会影响物物和儿童健康。关于阻燃剂和出生的影响的研究 结果混合在一起。通常通过血液和 怀孕期间的尿液样本。该抽样方案在检测其他持续环境时受到限制 可能也是相关暴露的污染物。为了解决这一限制，有机硅的发展 腕带是一种新颖的方法，用于测量多币暴露，因为它的无创和最少 繁重的性质，特别是对于孕妇。在许多人中暗示了氧化应激 从育种到流产，母体血管疾病和早产，生殖和妊娠障碍 生日4。已经建议将其作为将化学暴露和不良妊娠结局联系起来的机制。到 这一目标，拟议的项目将检查阻燃剂与邻苯二甲酸酯生物标志物之间的关系 通过硅胶腕带及其与妊娠长度和出生体重的关联来衡量。这也将是 使用新罕布什尔州对这种关系上氧化应激的潜在介导的探索性分析 出生队列研究。