Puerto Rico Testsite for Exploring Contamination Threats (PROTECT)

波多黎各探索污染威胁的试验场（PROTECT）

• 批准号: 10796254
• 负责人: Akram N Alshawabkeh
• 金额: $ 1.49万
• 依托单位: NORTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10796254
• 关键词: Address; Back; Chemicals; Communities; Development; Education; Environmental Health; Exposure to; Family; Fetal Growth Retardation; Funding; General Population; Gestational Diabetes; Hazardous Chemicals; Health; Human; Incidence; Industry; Laboratories; Link; Low Birth Weight Infant; Medical; Mentors; Participant; Pesticides; Pharmacology and Toxicology; Poly-fluoroalkyl substances; Pre-Eclampsia; Pregnancy Outcome; Pregnant Women; Puerto Rico; Reporting; Research; Research Personnel; Risk; Science; Triclosan; Universities; Woman; Work; adverse pregnancy outcome; cohort; doctoral student; follow-up; interest; manufacture; medical schools; member; obesity in children; phthalates; professor; programs; skill acquisition; skills; social health determinants; study population; superfund site; triclocarban

PFAS and the impact on human health: From the laboratory to the community Since 2010, PROTECT (Puerto Rico Testsite for Exploring Contamination Threats) investigators have studied the effects of hazardous chemicals, commonly found at Superfund sites, on adverse pregnancy outcomes in women living in the Northern Karst region of Puerto Rico. The primary chemicals found to be present in the PROTECT cohort of pregnant women are pesticides, phthalates, bisphenols, triclosan, and triclocarban (Lewis et al, 2014; Ferguson et al., 2019; Aker et al., 2019). PFAS (per- and poly-fluoroalkyl substances) are a class of over 12,000 chemicals that have been manufactured and used in a variety of industries worldwide since the 1940s. There is evidence that exposure to PFAS is linked with detrimental effects on human health. In pregnant women, PFAS exposure has been associated with low birth weight (Ashley et al., 2017) and increased incidence of gestational diabetes, childhood obesity, preeclampsia, and fetal growth restriction (Szilagyi et al., 2020). Despite the increased number of contaminants studied in PROTECT, the presence of PFAS in pregnant women, their families, and the general population in Puerto Rico is unknown. This request for KC Donnelly funding starts to address this need for more exploratory research. I am a doctoral student in Social Determinants of Health at the University of Puerto Rico Medical Sciences Campus. As a member of the PROTECT team since 2019, I am particularly interested in the effects of hazardous chemicals on pregnancy outcomes. I am also very active in the Community and Engagement Core and the initiative to provide results of harmful exposures and follow-up education for risk avoidance to our study participants through the Report Back program. My project has two Specific Aims, one that will broaden my environmental health science skills under the guidance of Dr. Jamie DeWitt, a professor in the Department of Pharmacology and Toxicology at the Brody School of Medicine at East Carolina University. The second aim is to work with my mentors in PROTECT (Drs. Velez-Vega and Brown) to apply my newly acquired skills toward the development of an educational program that will enhance our Report Back initiative to the benefit our study population as well as all communities in Puerto Rico that need to be informed about the risks of PFAS exposure.

PFAS 及其对人类健康的影响：从实验室到社区 自 2010 年起，PROTECT（波多黎各污染威胁探索试验场） 调查人员研究了超级基金中常见的危险化学品的影响 波多黎各北部喀斯特地区妇女不良妊娠结局的网站 里科. PROTECT 孕妇队列中发现的主要化学物质 是农药、邻苯二甲酸盐、双酚、三氯生和三氯卡班（Lewis 等人，2014 年；Ferguson 等人） 等，2019；阿克等人，2019）。 PFAS（全氟烷基物质和多氟烷基物质）是一类超过 12,000 种化学物质， 自 20 世纪 40 年代以来，已在全球各个行业中生产和使用。有 有证据表明接触 PFAS 会对人类健康产生有害影响。怀孕时 对于女性，PFAS 暴露与低出生体重有关（Ashley 等人，2017 年） 妊娠糖尿病、儿童肥胖、先兆子痫和胎儿生长的发生率增加 限制（Szilagyi 等人，2020）。尽管研究的污染物数量有所增加 保护孕妇、其家人和一般人群中存在的 PFAS 波多黎各的情况未知。对 KC Donnelly 资金的请求开始满足这一需求 更具探索性的研究。 我是波多黎各大学健康社会决定因素的博士生 医学科学校区。作为 2019 年以来 PROTECT 团队的一员，我特别 对危险化学品对妊娠结局的影响感兴趣。我也非常活跃 社区和参与核心以及提供有害暴露结果的倡议 以及通过报告返回对我们的研究参与者进行风险规避的后续教育 程序。我的项目有两个具体目标，其中之一将扩大我的环境健康 在该系教授 Jamie DeWitt 博士的指导下掌握科学技能 东卡罗来纳大学布罗迪医学院药理学和毒理学。这 第二个目标是与我的 PROTECT 导师（Velez-Vega 博士和 Brown 博士）合作，应用我的 新获得的技能用于制定教育计划，这将增强我们的能力 报告倡议旨在造福我们的研究人群以及波多黎各的所有社区 Rico 需要了解 PFAS 暴露的风险。

项目成果

Associations between mixtures of urinary phthalate metabolites with gestational age at delivery: a time to event analysis using summative phthalate risk scores.

• DOI: 10.1186/s12940-018-0400-3
• 发表时间: 2018-06-20
• 期刊: Environmental health : a global access science source
• 作者: Boss J;Zhai J;Aung MT;Ferguson KK;Johns LE;McElrath TF;Meeker JD;Mukherjee B
• 通讯作者: Mukherjee B

Exocycilic DNA Adducts in a Murine Model of Non-alcoholic Steatohepatitis.

非酒精性脂肪性肝炎小鼠模型中的外环 DNA 加合物。

• DOI: 10.4172/2157-2518.s3-003
• 发表时间: 2013
• 期刊: Journal of carcinogenesis & mutagenesis
• 作者: Peluso,MarcoEM;Munnia,Armelle;Tarocchi,Mirko;Arciello,Mario;Balsano,Clara;Giese,RogerW;Galli,Andrea
• 通讯作者: Galli,Andrea

Michigan's Gelman Site 1,4-Dioxane Groundwater Contamination: Still Spreading Decades after Detection.

密歇根州盖尔曼遗址 1,4-二恶烷地下水污染：检测后数十年仍在蔓延。

• DOI: 10.1016/j.coesh.2022.100405
• 发表时间: 2022
• 期刊: Current opinion in environmental science & health
• 作者: Loch-Caruso,Rita;Rayle,Roger;Caruso,VincentP;Bailey,RobertE;Collins,Elizabeth;Knol,KathleenP
• 通讯作者: Knol,KathleenP

Malondialdehyde-deoxyguanosine and bulky DNA adducts in schoolchildren resident in the proximity of the Sarroch industrial estate on Sardinia Island, Italy.

居住在意大利撒丁岛 Sarroch 工业区附近学童的丙二醛-脱氧鸟苷和大量 DNA 加合物。

• DOI: 10.1093/mutage/get005
• 发表时间: 2013
• 期刊: Mutagenesis
• 影响因子: 2.7
• 作者: Peluso,Marco;Munnia,Armelle;Ceppi,Marcello;Giese,RogerW;Catelan,Dolores;Rusconi,Franca;Godschalk,RogerWL;Biggeri,Annibale
• 通讯作者: Biggeri,Annibale

Trends in Environmental Tobacco Smoke (ETS) Exposure and Preterm Birth: Use of Smoking Bans and Direct ETS Exposure Assessments in Study Designs.

环境烟草烟雾 (ETS) 暴露和早产的趋势：在研究设计中使用禁烟令和直接 ETS 暴露评估。

• DOI: 10.1021/acs.chemrestox.7b00054
• 发表时间: 2017
• 期刊: Chemical research in toxicology
• 影响因子: 4.1
• 作者: Elkin,ElanaR;O'Neill,MarieS
• 通讯作者: O'Neill,MarieS