ECHO-PROTECT Cohort Study Site in Puerto Rico

波多黎各 ECHO-PROTECT 队列研究基地

• 批准号: 10744904
• 负责人: Akram N Alshawabkeh
• 金额: $ 490.01万
• 依托单位: NORTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10744904
• 关键词: Adaptive Behaviors; Adolescence; Affect; Area; Biological; Biological Markers; Birth; Brain; Chemical Exposure; Chemicals; Child; Child Development; Child Health; Childhood; Clinical; Cognition; Cohort Studies; Collaborations; Communication; Conceptions; Coupled; Data; Data Element; Development; Diet; Discrimination; Education; Emotional; Environmental Exposure; Exposure to; Flame Retardants; Future; General Population; Goals; Health; Hormones; Household; Income; Individual; Infant; Inflammation; Intervention; Knowledge; Language; Lead; Life; Measures; Mediating; Metals; Minority Groups; Mission; Modification; Mothers; Motor; Nature; Neighborhoods; Obesity; Occupations; Outcome; Outcome Study; Oxidative Stress; Parabens; Participant; Patient Recruitments; Persons; Pesticides; Phase; Phenols; Policies; Population; Population Heterogeneity; Poverty; Pregnancy; Pregnancy Outcome; Protocols documentation; Puberty; Public Health; Puerto Rico; Questionnaires; Research; Risk Assessment; Role; Sample Size; Sampling; Science; Site; Statistical Methods; Testing; Underserved Population; Unhealthy Diet; Weight; Weight Gain; anogenital distance; cohort; early childhood; environmental chemical; environmental chemical exposure; epigenomics; experience; feeding; follow-up; girls; health care availability; in utero; infancy; innovation; maternal obesity; maternal weight; metabolomics; middle childhood; mother nutrition; multidisciplinary; neurodevelopment; obesity in pregnancy; phthalates; pregnant; programs; recruit; reproductive; reproductive development; response; social; social disparities; social health determinants

PROJECT SUMMARY The effect of early environmental exposures on child health and development is an important area of public health that no single cohort, or even a few, can answer alone – particularly when coupled with social determinants of health (SDOH) that may influence these exposures and modify their effects. Determining this effect becomes more challenging when considering that these exposures influence multiple interrelated health outcomes such as obesity, neurodevelopment and reproductive development. The ECHO-PROTECT Cohort Site in Puerto Rico (PR) will focus on these health outcomes, taking advantage of the rich and large sample size, diversity, and longitudinal nature of the national ECHO Cohort and multi-disciplinary expertise across the ECHO consortium. ECHO-PROTECT will contribute innovative research to (Aim 1) examine the influence of SDOH on maternal diet and obesity during pregnancy, child diet and obesity during early to middle childhood, and the relationship between maternal-child diet and onset of puberty and (Aim 2) determine the relationship between in utero and early childhood exposure to environmental chemicals, individually and as mixtures, and neurodevelopment and reproductive development, across early childhood, middle childhood, and adolescence. Most importantly, ECHO-PROTECT will build upon the ongoing ECHO-PROTECT cohort in PR (Aim 3) to follow up and collect data and biospecimens from the 1,100 children that are participating in the current ECHO- PROTECT cohort, as well as recruit an additional 1,200 pregnant participants, yielding 1,000 more children, for a total of 2,100 children contributing data and biospecimens to the ECHO Cohort from Puerto Rico – an underserved, highly-exposed population. The proposed 1,200 new pregnancies will include at least 125 completed pregnancies with preconception data (Aim 4), tracked from a cohort of 500 potential preconception participants and, if available, their conceiving partner. ECHO-PROTECT research will contribute meaningfully to ECHO’s mission, offering (a) an important cohort that will enrich consortium wide data, (b) significant, innovative science on the influence of SDOH and exposure to multiple chemicals on multiple interrelated health outcomes such as obesity, neurodevelopment, and reproductive development, and (c) expertise to lead and participate in additional new scientific directions involving biomarkers of exposure or biologic response, child brain or reproductive development, and statistical methods in collaboration with the ECHO consortium, to answer impactful and cutting-edge research questions. Results from our study will inform future clinical intervention, risk assessment and policy-setting efforts, with direct relevance to both the underserved population of Puerto Rico and the U.S. general population.

项目概要 早期环境暴露对儿童健康和发育的影响是公众关注的一个重要领域 健康问题是任何一个群体，甚至少数群体，都无法单独回答的——尤其是与社交相结合时 可能影响这些暴露并改变其影响的健康决定因素 (SDOH)。 当考虑到这些暴露影响多种相互关联的健康时，效果变得更具挑战性 ECHO-PROTECT 队列的结果包括肥胖、神经发育和生殖发育。 波多黎各 (PR) 的站点将利用丰富且大的样本来关注这些健康结果 国家 ECHO 队列的规模、多样性和纵向性质以及整个国家的多学科专业知识 ECHO 联盟将贡献创新研究以（目标 1）检验影响 SDOH 对孕期母亲饮食和肥胖、儿童早期至中期肥胖的影响， 以及母婴饮食与青春期开始之间的关系和（目标 2）确定关系 在子宫内和幼儿期接触环境化学品（单独或混合物），以及 神经发育和生殖发育，涵盖幼儿期、幼儿期和青春期。 最重要的是，ECHO-PROTECT 将建立在公关领域正在进行的 ECHO-PROTECT 队列（目标 3）的基础上 跟踪并收集参加当前 ECHO- 的 1,100 名儿童的数据和生物样本 保护队列，并招募另外 1,200 名怀孕参与者，从而产生 1,000 名儿童， 共有 2,100 名来自波多黎各的儿童向 ECHO 队列贡献数据和生物样本 - 拟议的 1,200 例新怀孕中将包括至少 125 例。 使用孕前数据完成妊娠（目标 4），从 500 名潜在孕前数据的队列中追踪 参与者及其怀孕伴侣（如果有）。 ECHO-PROTECT 研究将为 ECHO 的使命做出有意义的贡献，提供 (a) 一个重要的群体 这将丰富联盟范围内的数据，(b) 关于 SDOH 和 接触多种化学物质会影响多种相互关联的健康结果，例如肥胖、神经发育、 和生殖发育，以及（c）领导和参与其他新科学方向的专业知识 涉及暴露或生物反应的生物标志物、儿童大脑或生殖发育以及统计 与 ECHO 联盟合作的方法，回答有影响力和前沿的研究问题。 我们的研究结果将为未来的临床干预、风险评估和政策制定工作提供信息， 与波多黎各服务不足的人口和美国普通民众直接相关。