Environmental Influences on Child Health Outcomes in Puerto Rico (ECHO-PRO)

环境对波多黎各儿童健康结果的影响 (ECHO-PRO)

• 批准号: 10475485
• 负责人: Akram N Alshawabkeh
• 金额: $ 11.09万
• 依托单位: NORTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10475485
• 关键词: Address; Affect; Age; Air Pollution; Area; Aromatic Polycyclic Hydrocarbons; Biological; Birth; Birth Rate; Chemicals; Child; Child Development; Child Health; Childhood; Childhood Asthma; Clinical; Collaborations; Communication; Complex; Congenital Abnormality; Coupled; Data; Data Collection; Data Set; Development; Diet; Disease; Endocrine disruption; Environment; Environmental Engineering technology; Environmental Exposure; Environmental Health; Environmental Impact; Environmental Pollution; Environmental Risk Factor; Epidemiologist; Evaluation; Exposure to; Fetal Growth; Future; General Population; Hazardous Waste Sites; Health; Hispanics; Home; Infant; Inflammation; Infrastructure; Intervention; Knowledge; Measures; Mediator of activation protein; Medical Records; Metals; Michigan; Mothers; Motor; National Institute of Environmental Health Sciences; Obesity; Outcome; Oxidative Stress; Parabens; Particulate Matter; Pattern; Phenols; Policies; Poverty; Pregnancy; Pregnant Women; Premature Birth; Protocols documentation; Public Health; Puerto Rican; Puerto Rico; Questionnaires; Research; Respiratory Signs and Symptoms; Risk Assessment; Sampling; Scientist; Social Workers; Socioeconomic Status; Source; Speech; Standardization; Statistical Methods; Superfund; Testing; Underserved Population; Universities; Visit; adverse birth outcomes; autism spectrum disorder; base; cardiometabolism; cognitive ability; cohort; early childhood; environmental stressor; experience; fetal; follow-up; health disparity; improved; in utero; lung volume; maternal stress; multidisciplinary; neurodevelopment; novel; nutrition; obesity in children; pediatrician; phthalates; programs; psychosocial; recruit; respiratory health; sample collection; social; superfund site; toxicant; trend; volatile organic compound

PROJECT SUMMARY: Exposure to a complex mix of environmental stressors during critical fetal and childhood development periods is an important yet understudied area of public health, particularly when coupled with psychosocial and other factors that may modify the effects of these exposures. Existing studies usually investigate the effect of single toxicants or exposures and so do not reflect the reality that children experience combinations of exposures simultaneously. To address this gap, the proposed Environmental Influences on Child Health Outcomes in Puerto Rico (ECHO-PRO) will leverage and build upon an active birth cohort in Puerto Rico (“PROTECT”, P42ES017198) that has recently initiated infant/child follow-up (“CRECE”, P50ES026049). ECHO-PRO will provide data and biospecimens for 570 mother-child pairs already participating in the PROTECT/CRECE cohort, as well as recruit an additional 1100 pregnant women, yielding 990 more children, for a total of 1560 mother-child pairs (88% retention by completion of study) with data and biospecimens to be integrated into the ECHO Consortium. To accomplish this, we will use our established, proven PROTECT/CRECE infrastructure and our experience in recruitment, follow up, sample and data collection, management and analysis, to (a) recruit pregnant women, (b) collect and analyze biological samples during pregnancy, at birth and at annual child visits through age 5, and (c) collect detailed demographic, health, and exposure information collected through questionnaires, evaluations and medical record abstraction during pregnancy, at birth and at annual child visits through age 5. In addition, the multidisciplinary ECHO-PRO team will study (using novel statistical methods for analysis of mixtures) the impact of multiple environmental exposures and exposure mixtures; specifically the relationship between exposure (maternal, in utero and/or during early childhood) to common mixtures of environmental contaminants (air pollution, metals, polycyclic aromatic hydrocarbons, phthalates, phenols, parabens), as well as their mechanistic mediators and modifying factors, on the four ECHO outcome domains: (1) adverse birth outcomes, including preterm birth, reduced fetal growth, and birth defects, (2) obesity, including maternal gestational glycemia and measures of child adiposity and cardiometabolic health, (3) neurodevelopment, including measures of child personal-social, adaptive, motor, communication and cognitive abilities and (4) respiratory health, including measures of child cardiorespiratory patterning, lung volume, and respiratory symptoms. Finally, ECHO-PRO will integrate and compare data obtained through our cohort with the overall ECHO data to better understand the environmental influences on child health outcomes in Puerto Rico and the U.S. mainland.

项目摘要：在关键胎儿和 儿童发展期是一个重要的公共卫生领域，尤其是 再加上可以改变这些暴露影响的社会心理和其他因素。现有研究 通常研究单一毒物或暴露的影响，因此不反映儿童的现实 简单地体验暴露的组合。 为了解决这一差距，拟议的环境对波多黎各儿童健康成果的影响 （Echo-Pro）将利用并建立在波多黎各的活跃分娩队列（“ Protect”，P42ES017198） 最近开始了婴儿/儿童随访（“ Crece”，P50ES026049）。 Echo-Pro将提供数据和 570个母子双子的生物测量已经参与了保护/Crece队列 招募另外1100名孕妇，产生了990个孩子，共有1560个母子对 （通过完成研究为88％的保留），并将数据和生物测量集成到回声中 财团。 为此，我们将利用我们已建立的，已验证的保护/Crece基础设施和我们的经验 在招聘，跟进，样本和数据收集，管理和分析中，（a）招募怀孕 妇女，（b）在怀孕期间，出生时和每年的儿童访问期间收集和分析生物样品 5岁，（c）收集通过 怀孕期间，出生时和年度访问期间的问卷，评估和医疗记录抽象 到5岁。 此外，跨学科回声奖团队将研究（使用新颖的统计方法进行分析 混合物）多种环境暴露和暴露混合物的影响；特别是 暴露（母亲，子宫内和/或幼儿期间）与常见混合物之间的关系 环境污染物（空气污染，金属，多环芳烃，邻苯二甲酸盐，邻苯二甲酸盐， 苯酚，对羟基苯甲酸酯）及其机械介质和修饰因素，在四个回波上 结果领域：（1）不良出生结果，包括早产，胎儿生长减少和出生 缺陷，（2）肥胖，包括孕产胎血糖和儿童肥胖和 心脏代谢健康，（3）神经发育，包括儿童个人社会，适应性，运动的度量 沟通和认知能力以及（4）呼吸健康，包括儿童心肺的措施 图案，肺部体积和呼吸道症状。最后，Echo-Pro将集成和比较数据 通过我们的队列获得了整体回声数据，以更好地了解环境影响 波多黎各和美国大陆的儿童健康成果。