Immuno-genetics on Mongoloid in Pan-Pacific and Northland Areas

泛太平洋和北陆地区蒙古人种的免疫遗传学

基本信息

批准号：
18406006
负责人：
TAJIMA Kazuo
金额：
$ 9.45万
依托单位：
Aichi Cancer Center Research Institute
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18406006/
关键词：
Ethnoepidemiology Mongoloid HTLV-I HLA Fat metabolism 民族疾学イヌイット族 HBV

项目摘要

To contribute to the establishment of comprehensive information on worldwide Mongoloid dispersal, we have studied ethnoepidemiologic features of tumour viruses and immuno-genetic characteristics among Mongoloids during the last twenty years. To analyze geographic and ethnic distribution of HTLV-1and genetic polymorphism patterns of human leucocyte antigen (HLA) and fat metabolites among Mongoloid people in Northland areas in the present study, we focused on 200 Inuit people in North Canada and East Greenland (Denmark). We projected field works in winter season (January of February) when indigenous people settle down in one place according to the mentioned above purposes. In 2006 we planned a field work on Inuit people in Yukon area, North Canada in collaboration with University of Vancouver, but we finally could not get official permission of collecting blood samples from indigenous people from the authority of British Columbian Government. Instead of it, we invested HLA subtypes (DR, DP, DQ) frequency among 600 Japanese people in Aichi Prefecture to compare characteristic distribution among worldwide Mongoloids people. In 2007 we focused on Inuit people in East Greenland, Denmark and conducted a field work to collect blood samples from 100-200 people in Ittoqqortoormiit, but we had to obliged giving up collecting blood samples because of order to stop from the Greenland authority. Nowadays we are negotiating collaboration with Danish researchers who have collected blood samples from Inuit people in the same area during the last several years. On the other hand we have established lymphocytes bank (Sonoda-Tajima Collection) of worldwide Mongoloid people which we collected during the last 20 years linked with the present study, at the Bio-resource Center, RIKEN Institute for multipurpose usage of those valuable materials. We put together comprehensive information on worldwide distribution of HTLV-I among Mongoloids and their immuno-genetic characteristics.

为了有助于建立关于全球蒙古人种传播的综合信息，我们研究了过去二十年蒙古人种肿瘤病毒的民族流行病学特征和免疫遗传学特征。在本研究中，为了分析北部地区蒙古人种中HTLV-1的地理和种族分布以及人类白细胞抗原（HLA）和脂肪代谢物的遗传多态性模式，我们重点关注了加拿大北部和东格陵兰岛（丹麦）的200名因纽特人。根据上述目的，我们预计在冬季（二月一月）原住民在一个地方定居时进行实地工作。 2006年，我们计划与温哥华大学合作，对加拿大北部育空地区的因纽特人进行实地考察，但最终未能获得不列颠哥伦比亚省政府当局的正式许可，采集原住民的血液样本。相反，我们研究了爱知县 600 名日本人的 HLA 亚型（DR、DP、DQ）频率，以比较全球蒙古人种的特征分布。 2007年，我们以丹麦东格陵兰岛的因纽特人为对象，在Ittoqortoormiit进行了实地工作，采集了100-200人的血样，但由于格陵兰当局的停止命令，我们不得不放弃采集血样。目前，我们正在与丹麦研究人员洽谈合作，他们在过去几年中从同一地区的因纽特人身上采集了血液样本。另一方面，我们在理化学研究所生物资源中心建立了过去20年收集的世界各地蒙古人种淋巴细胞库（园田田岛收集），与本研究相关，以便对这些有价值的材料进行多用途利用。我们汇总了有关 HTLV-I 在蒙古人种中的全球分布及其免疫遗传特征的综合信息。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Alcohol dehydrogenase 2 His47Arg polymorphisms influences drinking Habit independently of aldehyde dehydrogenase 2 Glu487 Lyspolymorphism : analysis of 2, 299 Japanese subject

乙醇脱氢酶 2 His47Arg 多态性独立于醛脱氢酶 2 Glu487 Lys 多态性影响饮酒习惯：对 2, 299 名日本受试者的分析

DOI：
发表时间：
2006
期刊：
Carcinogenesis 27
影响因子：
0
作者：
Iseki;M.;Tokoro;M;Saki Nagano;Fujita E;都野展子;Yamasaki S;仲本賢太郎;Matsuo K;都野展子;所正治;都野展子;Matsuo K;井関基弘;Matsuo K
通讯作者：
Matsuo K

Two novel NKG2D ligands of the mouse H60 family with differential expression patterns and binding affinities to NKG2D