Immunogenetic study on Mongoloids in Asian-Pacific and Polar areas

亚太和极地地区蒙古人种的免疫遗传学研究

• 批准号: 15256002
• 负责人: TAJIMA Kazuo
• 金额: $ 13.15万
• 依托单位: Aichi Cancer Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15256002/
• 关键词: Mongoloid; HTLV-I; HBV; HCV; Lipid metaboplites; Sami people; Nenetz people; Ethnoepidemiology; HTLV-I; サーメ族; チベット族

To clarify immunogenetic characteristics of Mongoloids in Asian Pacific regions from unique distribution of human T-cell leukemia virus(HTLV-I) and hepatitis B virus(HBV), the present international comparative study was conducted in the North Scandinavian and Northwestern Russian areas.1)In cooperation with epidemiologists of Osb University and Tromse University in Norway, we analyzed anti-HTLV-I antibodies of indigenous people in North Norway in 2003. We used 800 serum samples (400 Sami people and 400 non-Sami people) after getting official permission of Norway authorities and Sami community. All samples were collected 25 years ago for the other purposes and stored in the deep freezer in Oslo University. All samples were negative anti-HTLVI and we concluded that North Norway indigenous Sami people don't carry HTLV-I.2)In cooperation with Arkhangelsk University, we conducted field work targeting Nenezt people in Nariyan Mar, Nenets autonomous areas for three days in the end of 2004 We … More collected 10 ml blood samples from 109 subjects (patients of Central Clinics and general inhabitants) in Krasnoe town after getting informed consent from each subject. We separated buffy coat from plasma in the laboratory of the Central Clinics and carried back them to Arkhangelsk University. We analyzed antibodies of HTLV-I and we could not find a positive carrier. In terms of hepatitis viruses, we found 3 (2.8%) and 30 (28%) positives of anti-HCV and anti-HBVs. Among 30 anti-HBVs positives, there is no HBV antigen carrier and we could not confirm a genetic subtype of HBV in this population.From the present study including the previous studies held in Asian Continent, we could not confirm clustering of HTLV-I carriers among indigenous Mongoloids except Japanese in Japan archipelago. We need final studies on HTLV-I to clarify Mongoloids dispersal as to 1)confirmation of HTLV-I among Inuit people in the northeastern Greenland, and 2)investigation of HTLV-I among mummies 8,000-500 years old buried in Andes desert. Less

为了从人类 T 细胞白血病病毒（HTLV-I）和乙型肝炎病毒（HBV）的独特分布中阐明亚太地区蒙古人种的免疫遗传学特征，本次国际比较研究在北斯堪的纳维亚地区和俄罗斯西北部地区进行了1。 ）我们与挪威奥斯布大学和特罗姆瑟大学的流行病学家合作，于2003年分析了挪威北部原住民的抗HTLV-I抗体。我们使用了800份血清样本（400 名萨米人和 400 名非萨米人）在获得挪威当局和萨米社区的正式许可后，所有样本均于 25 年前收集用于其他目的，并保存在奥斯陆大学的冷冻柜中。所有样本均呈阴性抗 HTLVI。我们的结论是，挪威北部土著萨米人不携带 HTLV-I。2）与阿尔汉格尔斯克大学合作，我们针对涅涅茨自治区 Nariyan Mar 的 Nenezt 人进行了为期三年的实地调查2004 年底，我们在征得每个受试者的知情同意后，从克拉斯诺镇的 109 名受试者（中心诊所的患者和普通居民）采集了 10 毫升血液样本，并在中心诊所的实验室中将血沉棕黄层与血浆分离。并带回阿尔汉格尔斯克大学，我们分析了HTLV-I抗体，没有发现肝炎病毒阳性携带者，我们发现了3个（2.8%）。 30 例 (28%) 抗 HCV 和抗 HBV 阳性，其中 30 例抗 HBV 阳性，没有 HBV 抗原携带者，我们无法确认该人群中 HBV 的遗传亚型。在亚洲大陆举行的会议上，我们无法确认除日本列岛的日本人外，HTLV-I 携带者在本土蒙古人种中的聚集，我们需要对 HTLV-I 进行最终研究来澄清蒙古人种。 1）在格陵兰岛东北部的因纽特人中确认 HTLV-I，以及 2）在安第斯沙漠埋藏的 8,000-500 岁木乃伊中调查 HTLV-I。

项目成果

Associations between polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and susceptibility to malignant lymphoma.

• 发表时间: 2003
• 期刊: Haematologica
• 影响因子: 10.1
• 作者: A. Hishida;K. Matsuo;N. Hamajima;Hidemi Ito;M. Ogura;Y. Kagami;H. Taji;Y. Morishima;N. Emi;K. Tajima

Cancer mortality in Japan (1950-2000).

日本癌症死亡率（1950-2000 年）。

• 发表时间: 2004
• 期刊: Gann Monogr.Cancer Res. 41
• 作者: Kuroishi;T.
• 通讯作者: T.

Cancer mortality statistics in 30 ciountries (1953-1997).

30 个国家的癌症死亡率统计（1953-1997 年）。

• 发表时间: 2004
• 期刊: Gann Monogr Cancer Res. 51
• 作者: Fukushima;K.;福島和彦(共著);Kuriki K.;Higashi N.;Senoo H.;Hanai S.;Sonoda J.;Chiba H.;Matsuo K.;Mizuno S.;Matsuo K.;Ito H.;Kuroishi T.;Kuroishi T.
• 通讯作者: Kuroishi T.

Lack of HTLV-I carriers in the Sami, an ethnic group living in the arctic area in Norway.

居住在挪威北极地区的萨米族人缺乏 HTLV-I 携带者。

• 发表时间: 2004
• 期刊: Asian Pacific J.Cancer Prev 5
• 作者: Chiba;H.
• 通讯作者: H.

Cancer mortality statistics in 30 ciountiries(1953-1997).

30个国家癌症死亡率统计（1953-1997）。

• 发表时间: 2004
• 期刊: Gann Monogr Cancer Res 51
• 作者: Fukushima;K.;福島和彦(共著);Kuriki K.;Higashi N.;Senoo H.;Hanai S.;Sonoda J.;Chiba H.;Matsuo K.;Mizuno S.;Matsuo K.;Ito H.;Kuroishi T.;Kuroishi T.;Banda T.;Chiba H.;Matsuo K.;Ito H.;Kuroishi T.;Kuroishi T.
• 通讯作者: Kuroishi T.