Anthro-genetics on Paleomongoloid in Pan-Pacific and Northland Areas

泛太平洋和北陆地区古蒙古人种的人类遗传学

基本信息

批准号：
11691226
负责人：
TAJIMA Kazuo
金额：
$ 11.81万
依托单位：
Aichi Cancer Center
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2001
项目状态：
已结题

项目摘要

Human T-cell leukemia virus type 1 (HTLV-l) is spreading throughout the world with microgeographical clusters of hyperendemicity. Epidemiologic evidences on HTLV among Mongoloids in the world showed that HTLV-l is highly endemic in South Japan and in the Andes district of South America. In the other hand HTLV type 2 (HTLV-II) is broadly distributed in the whole South America except the Andes line. The HLA haplotypes of these two carriers were mutually exclusive, i.e., the HLA haplotypes of Andes HTLV-I carriers were common among Japanese while those of HTLV-II carriers were prevalent among North American Indians. This suggested that HLA haplotypes might be ethnically segregated among South American natives and might be involved in the genetic susceptibility to HTLV-I and HTLV-II infections. In a previous study in this program, gene fractions of proviral HTLV-I from Andean mummy aged 1500 years was detected. This observation suggested that HTLV-I may have existed at least 1000 years before aboriginal Andean migrated from the Asian Continent and settled down in the Andes.In Tibetan populations in China, the hepatitis B virus (HBV) genotypes have not yet been studied up until now. HBV distributed in the world is classified into seven genotypes, designated as A to G, geographically separated. Since the prevalence of HBV infection in isolated Tibetan people in the east and west regions of Tibet was very high, the HBV genotypes were determined by PCR-microwell plate hybridization method using plasma DNA. We detected only genotype in Tibetan HBV This genotype C is known to be a predominant type of HBV among Asian Mongoloids, especially in Thailand and Korea These results revealed that the Tibetan villagers are not exposed by HTLV-I but highly infected with HBV, especially with genotype C. HBV and HLA gene sequences warrant further investigation in this context.

人类T细胞白血病病毒1型（HTLV-L）随着微观的微观群体而在世界各地传播。关于世界上蒙古人的HTLV的流行病学证据表明，HTLV-L在南部和南美安第斯山脉地区高度流行。另一方面，HTLV 2型（HTLV-II）在安第斯山脉系以外的整个南美分布。这两个载体的HLA单倍型是互斥的，即安第斯山脉HTLV-I载体的HLA单倍型在日本中很常见，而HTLV-II载体的HLA单倍型在北美印第安人中普遍存在。这表明HLA单倍型可能在南美本地人中被种族隔离，并且可能参与了对HTLV-I和HTLV-II感染的遗传敏感性。在该计划的先前研究中，检测到了1500岁的安第斯木乃伊的前病毒htlv-i的基因分数。这一观察结果表明，在原住民安第斯从亚洲大陆迁移并在安第斯山脉迁移到安第斯山脉之前，HTLV-I可能至少存在1000年。在中国的藏族人口中，乙型肝炎病毒（HBV）基因型尚未研究到现在。分布在世界上的HBV分为七个基因型，被指定为A至G，地理分离。由于西藏东部和西部地区分离的藏族人中HBV感染的患病率很高，因此使用血浆DNA通过PCR-Microwell Plate杂交方法确定HBV基因型。我们仅检测到藏族HBV中的基因型，该基因型C在亚洲蒙古人中是主要的HBV类型，尤其是在泰国和韩国，这些结果表明，藏族村民并未被HTLV-I暴露在HTLV-I中，但受到HBV的高度感染，尤其是与Genotype C.HBV和HBV sequencence contect contect context contect in Contect有关。