Anthropo-genetics on paleomongoloid in South America

南美洲古蒙古人种的人类遗传学

• 批准号: 09041195
• 负责人: TAJIMA Kazuo
• 金额: $ 5.7万
• 依托单位: Aichi Cancer Center
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09041195/
• 关键词: Japanese; Andeans; Mummy; DNA; HTLV human; beta-globin; Mitochondrial DNA; Ethnoepidemiology; HLA

To c1arify the paleoanthropological relationship between Japanese and Andeans, characteristics of provirus DNA of human T-cell leukemia virus (HTLV), mitochondrial DNA and nuclear DNA were compared among materials : 1) high and low landers in South America ; 2) Andean mummies ; and 3) southern Japanese. From DNA analysis of HTLV and human leukocyte antigens, it was clarified that high landers in the Andes area were closely related to southern Japanese, but people in other low lands were exclusively different from them. Specific gene human beta-globin was identified from two out of 104 mummies collected in Andes areas. Furthermore, one out two beta-globin positive Andean mummies about 1,500 years ago was positive for HTLV-I pX, too. Base analysis of D-loop regeon of mitochondrial DNA from 90 mummies in north Chile were completed and they showed four specific groups of mitochondrial DNA asshown in contemporary people in South America. These results porvides the first evidence that HTLV-I was carried by ancient Mongoloids to the Andes before the Colonial era. .

为了阐明日本和安第斯之间的古人类学关系，在材料之间比较了人类T细胞性白血病病毒（HTLV）的病毒DNA（HTLV）的特征，线粒体DNA和核DNA在材料之间进行了比较：1）南美的高和低地着陆器； 2）安第斯木乃伊； 3）南部日语。从对HTLV和人类白细胞抗原的DNA分析中，可以澄清说，安第斯山脉地区的高兰德斯与南部日本人密切相关，但其他低层土地的人们与它们完全不同。从安第斯山脉收集的104个木乃伊中的两个中鉴定出特定的基因β-珠蛋白。此外，大约1,500年前，HTLV-I PX也是阳性的两个Beta-Globin积极的Andean Mummies。对北智利90个木乃伊的线粒体DNA的D环横向进行了基础分析，他们展示了南美当代人在当代人中提出的四个特定的线粒体DNA组。这些结果提出了第一个证据，表明HTLV-I是在殖民时代之前由古代蒙古人携带的安第斯山脉。 。

项目成果

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Blagitko, N. 等人：“哥伦比亚、厄瓜多尔和智利美洲人中 HLA-DRB1 位点的多形性”人类免疫学 (Human Immunol.)54(1)。

Nishio, I.et al.: "A new congenital muscular dystrophy with mitochondrial structural abnormalities." Muscle & Nerve. 21. 40-47 (1998)

Nishio, I.et al.：“一种新的先天性肌营养不良症，伴有线粒体结构异常。”

Takamoto, T.: "HTLV-linfected T cells activate autologous CD4^+ T cells susciptible to HILV-I injection in a costimulatory molecule-dependent fashion" Eur.J.Immunol.27. 1427-1432 (1997)

Takamoto, T.：“HTLV 感染的 T 细胞以共刺激分子依赖的方式激活对 HILV-I 注射敏感的自体 CD4+ T 细胞”Eur.J.Immunol.27。

Ozawa, M.et al.: "Myoclonus epilepsy associated with ragged-red fibers : A G-to-A mutation at nucleotide pair 8363 in mitochondrial tRNA^<Lys> in to families." Muscle & Nerve. 20. 271-278 (1997)

Ozawa, M.et al.：“与参差不齐的红色纤维相关的肌阵挛癫痫：家族中线粒体 tRNA^<Lys> 核苷酸对 8363 处的 G-to-A 突变。”

Miura, T.et al.: "Molecular phylogency of human T-cell leukemia virus type I'and II of Amerindians in Colonbia and Chile." J.Mol.Evol.44. S76-S82 (1997)

Miura, T.等人：“哥伦比亚和智利美洲印第安人 I 型和 II 型人类 T 细胞白血病病毒的分子系统发育。”