Anthropo-genetics on paleomongoloid in South America

南美洲古蒙古人种的人类遗传学

• 批准号: 07041171
• 负责人: TAJIMA Kazuo
• 金额: $ 6.46万
• 依托单位: Aichi Cancer Center
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07041171/
• 关键词: Japanese; Andeans; Mummy; DNA; HTLV-I; Ethnoepidemiology; Immunogenetics; Archeology; Paleoanthropology

To clarify the paleoanthropological relationship between Japanese and Andeans, charactistics of provirus DNA of human T-cell leukemia virus type I (HTLV-I), mitochodrial DNA and nuclear DNA was compared among 1) Andeans in Colombia, Chile, Bolivia and Chile, 2) Andean mummies in south Peru and north Chile, and 3) southern Japanese. From DNA analysis of HTLV-I provirus and specific genes of human leukocyte antigen (HLA-DQ), it was clarified that Andeans are closely related to southern Japanese, but people in Amazone, Orinoco and Patagonia were very different from them. Specific genes of HLA-DQ and betaglobin was just identified from 6 mummies (1500-1000 years ago) and also base analysis of D-loop regeon of mitochondial DNA from 46 mummies (8000-500 years ago) in north Chile have been already completed. Through those ethnoepidemiological and immunogenetic studies in addition to traditional ancheological studies, a new evidence of historical dispersal of paleo-Andeans would be generated.

为了阐明日本人与安第斯人之间的古人类学关系，对 1) 哥伦比亚、智利、玻利维亚和智利的安第斯人的人类 T 细胞白血病病毒 I 型 (HTLV-I) 的原病毒 DNA、线粒体 DNA 和核 DNA 的特征进行了比较，2 ) 秘鲁南部和智利北部的安第斯木乃伊，以及 3) 日本南部。通过对HTLV-I原病毒和人类白细胞抗原（HLA-DQ）特定基因的DNA分析，阐明安第斯人与日本南部有密切关系，但亚马逊河、奥里诺科河和巴塔哥尼亚的人与他们有很大不同。刚刚从6具木乃伊（距今1500-1000年前）中鉴定出HLA-DQ和β珠蛋白的特异性基因，并且对智利北部46具木乃伊（距今8000-500年前）线粒体DNA D环区域的碱基分析也已完成。除了传统的考古学研究之外，通过这些民族流行病学和免疫遗传学研究，将产生古安第斯人历史扩散的新证据。

项目成果

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Motokawa, S.：“日本岛上 HTLV-I 携带者的关节病患病率很高”《风湿病年鉴》。

Nishino,I.: "A novel mutation in the mitochondrial tRNA^<Thr> gene associated with a mitochondrial encephalomyopathy" Biochem.Biophy.Res.Commun.225. 180-185 (1996)

Nishino,I.：“与线粒体脑肌病相关的线粒体 tRNA^<Thr> 基因的新突变”Biochem.Biophy.Res.Commun.225。

Hammer,M.: "Y chromosomal DNA variation and the peopling of Japan" Am J.Hum.Genet.56. 951-962 (1995)

Hammer,M.：“Y 染色体 DNA 变异与日本人”Am J.Hum.Genet.56。

Horai,S.: "Prehistoric Dispersal of Mongoloids(eds.,E.Szathmary,T.Akazawa)" Oxford University Press, 14 (1995)

Horai,S.：“蒙古人种的史前扩散（编辑，E.Szathmary，T.Akazawa）”牛津大学出版社，14（1995）

Tajima,K.: "Ethnoepidemiology of Cancer Gann Monograph on Cancer Research (Eds.,K.Tajima,S.Sonoda)" Japan Scientific Societies Press, 10 (1996)

Tajima,K.：“癌症民族流行病学江恩癌症研究专着（Eds.，K.Tajima，S.Sonoda）”日本科学协会出版社，10（1996）