Anthhropological and genetic studies on ocular inflammatory diseases in Mongoloids

蒙古人种眼部炎症疾病的人类学和遗传学研究

基本信息

批准号：
10041203
负责人：
OHNO Shigeaki
金额：
$ 6.85万
依托单位：
Yokohama City University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A).
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 1999
项目状态：
已结题

项目摘要

It is well known that certain intractable inflammatory ocular diseases occur only in Mongoloid population. We have been studying the epidemiology, clinical feature, medical anthropology, and molecular genetics in mainly Vogt-Koyanagi-Harada disease and Behcet's disease.It was revealed that Vogt-Koyanagi-Harada disease was found in East Asian countries, Central Asian countries, North America and South America. In contrast, in Caucasians, this disease was rarely found. Vogt-Koyanagi-Harada disease was frequently seen in Australian Aborigini people, and possibly, in Papua New Guinean population. Since this disease is strongly associated with HLA-DRB1ィイD1*ィエD104 in East Asian patients, it is important to further study if the same HLA association is found in other populations.In Behcet's disease, no patients were found in East Asian countries. This disease was mainly found along the Silk Road, such as Korea, China, Iran, Turkey, and Morocco. In these countries, the number of new cases is still increasing and further epidemiological studies are needed to investigate the possible cause for this. In 1998's investigation we saw patients with Behcet's disease in Mongolia. This is the first report of the world. We have finished analyzing the molecular genetics of Greek patients with Behcet's disease. The frequency of HLA-BィイD1*ィエD15101 was 81.1 %, significantly higher than the healthy normal Greek controls. MICA-A6, one of the microsatellite alleles near the HLA region, was also significantly associated with this disease. It was interesting to find the same HLA association between Japanese and Greek patients with Behcet's disease.We have successfully gotten the blood samples from typical patients with Behcet's disease in Iran and Turkey. And it is expected that we could also get the samples from Morocco. Further HLA-DNA analyses will be performed in the near future.

众所周知，某些难治性炎症性眼病仅发生在蒙古人种中，我们一直在研究主要是Vogt-Koyanagi-Harada病和Behcet病的流行病学、临床特征、医学人类学和分子遗传学。小柳原田病见于东亚国家、中亚国家、北美和南美，而在白种人中则很少见。 Vogt-Koyanagi-Harada 病常见于澳大利亚原住民，也可能见于巴布亚新几内亚人群，因为这种疾病与东亚患者的 HLA-DRB1D1*D104 密切相关，因此进一步研究是否存在相同的 HLA 非常重要。在其他人群中也发现了这种关联。在白塞氏病中，没有发现患者，该病主要发现于丝绸之路沿线国家，如韩国、中国、伊朗、土耳其和摩洛哥这些国家的新病例数量仍在增加，需要进一步的流行病学研究来调查其可能的原因。1998年的调查中，我们在蒙古发现了白塞氏病患者。我们已经完成了希腊白塞氏病患者的分子遗传学分析，HLA-B*D1*D15101 的频率为 81.1。 %，显着高于健康正常希腊对照，MICA-A6（HLA 区域附近的微卫星等位基因之一）也与这种疾病显着相关。有趣的是，在日本和希腊白塞氏病患者之间发现了相同的 HLA 关联。我们已经成功地从伊朗和土耳其获取了典型白塞氏病患者的血液样本，预计近期也可以从摩洛哥获取样本进行进一步的HLA-DNA分析。未来。