Anthropological and genetic studies on uveitis in Mongoloids

蒙古人种葡萄膜炎的人类学和遗传学研究

基本信息

批准号：
07041166
负责人：
OHNO Shigeaki
金额：
$ 9.92万
依托单位：
Yokohama City University
依托单位国家：
日本
项目类别：
Grant-in-Aid for international Scientific Research
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1997
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07041166/
关键词：
Intractable uveitis Mongoloid Molecular genetics Molecular biology Mechanism of disease HLA Behcet's disease 難治性ぶどう膜性原田病 HLA遺伝子 MICA遺伝子ぶどう膜炎

项目摘要

Anthropological and molecular genetic studies on intractable uveitis syndromes which are frequently seen in the Mongoloid population were performed in Syria, Jordan, Mongol and Portugal in the fiscal year of 1997.In Syria and Jordan, there were many patients with Behcet's disease, and most of the patients in the Ophthalmology Department as well as the Rheumatology Department were those with Behcet's disease, quite similar to Japan. However, Vogt-Koyanagi-Harada's disease was rarely seen in these countries. In Syria, uveitis survey clinic was not yet established, and we advised them how to establish this for our future cooperative studies. In Jordan, however, a speciality clinic for Behcet's disease was already established, and we could see more than 50 typical cases of Behcet's disease. We could also get blood samples from these patients for the HLA-DNA typing. Molecular genetic analyzes on these samples are now in progress in our laboratory.In Mongolia, there were many patients with i … More ntractable uveitis syndromes, and typical cases with Behcet's disease or Vogt-Koyanagi-Harada's disease were seen. On the other hand, no patients were diagnosed as sarcoidosis in Mongolia. Clinical festures of uveitis in Mongolia was generally similar to Japan, as had been expected. In this investigation, we could establish a scientific basis for future cooperative studies.Portugal is located in the west end of the so-called Silk-Route, and similar to Japan and other Mediterranean countries, there were many Portuguese patients with Behcet's disease. However, Vogt-Koyanagi-Harada's disease or sarcoidosis was not as frequent as in Japan. In the next study, association of HLA-B^<**>5101 is to be studied in Portuguese patients with Behcet's disease.Blood samples collected before from Saudi Arabia or Greece were also HLA-DNA typed in our laboratory this year, and the same HLA class I association with Japanese patients was found in these patients.We can conclude from these results that certain types of intractable uveitis frequently seen in the Mongoloid population are also seen along with the Silk-Route, and these uveitis may have been spread along with the migration of the old Nomadic Tibes. Less

1997年在叙利亚和约旦，在叙利亚，约旦，约旦，蒙古人和葡萄牙在蒙古人种群中经常看到的关于可顽固性葡萄炎综合征的人类学和分子遗传研究。但是，在这些国家很少见到沃格特·卡亚纳吉·哈拉达氏病。在叙利亚，尚未建立葡萄膜炎调查诊所，我们建议他们如何为未来的教练研究建立这一点。然而，在约旦，已经建立了一个贝塞特氏病的专业诊所，我们可以看到50多例Behcet疾病的典型病例。我们还可以从这些患者的HLA-DNA键入中获取血液样本。在我们的实验室中，对这些样品的分子遗传分析现在正在进行中。在蒙古，有许多I…更多令人不安的葡萄炎综合症患者，而Behcet病或Vogt-Koyanagi-Harada病的典型病例被发现。另一方面，在蒙古中没有被诊断为结节病。正如预期的那样，蒙古葡萄膜炎的临床庆典通常与日本相似。这项投资，我们可以为未来的合作研究建立科学基础。然而，沃格特·卡亚纳吉·哈拉达氏病或结节病不像日本那样频繁。在下一项研究中，将在葡萄牙患者中进行HLA-B^<**> 5101的关联。今年还在我们的实验室中键入的HLA-DNA之前，还可以在这些患者中发现了同一类型的人群，也可以在我们的实验室中发现了同样的类型。随着丝绸路线，这些葡萄膜炎可能随着旧游牧锡的迁移而蔓延。较少的