Anthropological and genetic studies on uveitis in Mongoloids

蒙古人种葡萄膜炎的人类学和遗传学研究

基本信息

批准号：
07041166
负责人：
OHNO Shigeaki
金额：
$ 9.92万
依托单位：
Yokohama City University
依托单位国家：
日本
项目类别：
Grant-in-Aid for international Scientific Research
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1997
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07041166/
关键词：
Intractable uveitis Mongoloid Molecular genetics Molecular biology Mechanism of disease HLA Behcet's disease 難治性ぶどう膜性原田病 HLA遺伝子 MICA遺伝子ぶどう膜炎

项目摘要

Anthropological and molecular genetic studies on intractable uveitis syndromes which are frequently seen in the Mongoloid population were performed in Syria, Jordan, Mongol and Portugal in the fiscal year of 1997.In Syria and Jordan, there were many patients with Behcet's disease, and most of the patients in the Ophthalmology Department as well as the Rheumatology Department were those with Behcet's disease, quite similar to Japan. However, Vogt-Koyanagi-Harada's disease was rarely seen in these countries. In Syria, uveitis survey clinic was not yet established, and we advised them how to establish this for our future cooperative studies. In Jordan, however, a speciality clinic for Behcet's disease was already established, and we could see more than 50 typical cases of Behcet's disease. We could also get blood samples from these patients for the HLA-DNA typing. Molecular genetic analyzes on these samples are now in progress in our laboratory.In Mongolia, there were many patients with i … More ntractable uveitis syndromes, and typical cases with Behcet's disease or Vogt-Koyanagi-Harada's disease were seen. On the other hand, no patients were diagnosed as sarcoidosis in Mongolia. Clinical festures of uveitis in Mongolia was generally similar to Japan, as had been expected. In this investigation, we could establish a scientific basis for future cooperative studies.Portugal is located in the west end of the so-called Silk-Route, and similar to Japan and other Mediterranean countries, there were many Portuguese patients with Behcet's disease. However, Vogt-Koyanagi-Harada's disease or sarcoidosis was not as frequent as in Japan. In the next study, association of HLA-B^<**>5101 is to be studied in Portuguese patients with Behcet's disease.Blood samples collected before from Saudi Arabia or Greece were also HLA-DNA typed in our laboratory this year, and the same HLA class I association with Japanese patients was found in these patients.We can conclude from these results that certain types of intractable uveitis frequently seen in the Mongoloid population are also seen along with the Silk-Route, and these uveitis may have been spread along with the migration of the old Nomadic Tibes. Less

1997财政年度，对蒙古族人群中常见的顽固性葡萄膜炎综合征进行了人类学和分子遗传学研究，在叙利亚、约旦、蒙古和葡萄牙进行了研究。在叙利亚和约旦，白塞氏病患者较多，而且大多数人患有白塞氏病。眼科和风湿科的病人都是白塞氏病，和日本很相似。 Vogt-Koyanagi-Harada 病在这些国家很少见。在叙利亚，葡萄膜炎调查诊所尚未建立，我们建议他们如何为我们未来的合作研究建立这一诊所，但在约旦，已经建立了白塞氏病的专业诊所。已经建立了，我们可以看到50多个白塞氏病的典型病例，我们还可以从这些患者身上获取血液样本，对这些样本进行分子遗传拼接。在我们的实验室，有很多患有顽固性葡萄膜炎综合征的患者，并没有看到典型的白塞氏病或沃格特-小柳-原田氏病的病例。另一方面，蒙古国临床上没有诊断出结节病的患者。正如我们所预料的那样，蒙古的葡萄膜炎症状与日本大致相似。葡萄牙位于葡萄牙。在所谓丝绸之路的西端，与日本和其他地中海国家类似，葡萄牙也有很多白塞氏病患者，但沃格特-小柳-原田氏病或结节病并不像日本那样频繁。下一项研究将在患有白塞氏病的葡萄牙患者中研究 HLA-B^<**>5101 的关联性。之前从沙特阿拉伯或希腊采集的血液样本也进行了研究今年我们实验室进行了HLA-DNA分型，在这些患者中也发现了与日本患者相同的HLA I类关联。从这些结果我们可以得出结论，蒙古族人群中常见的某些类型的顽固性葡萄膜炎也与这些患者一起出现。丝绸之路，这些葡萄膜炎可能是随着古老的游牧民族的迁徙而传播的。