Investigation of disease susceptibility genes associated with intractable intraocular inflammation with racial differences and development of new antioxidant therapy

具有种族差异的顽固性眼内炎症相关疾病易感基因的研究及新型抗氧化疗法的开发

• 批准号: 19406028
• 负责人: OHNO Shigeaki
• 金额: $ 10.82万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19406028/
• 关键词: 疾患感受性遺伝子; ベーチェット病; 難治性内眼炎; アデノウイルス角結膜炎; 分子疫学; アスタキサンチン

In GWAS studies in Behcet disease, 2 new genes and HLA-B*510101 were found. In Vogt-Koyanagi-Harada disease, HLA-DRB1*0405 and several genetic associations were also found. Virological studies revealed 2 new human adenoviruses (HAdV 53 and 54). One of the carotenoids, astaxanthin showed significant increase of choroidal blood flow. DHMEQ, a new NF-κB blocker also showed significant suppression of experimental uveoretinitis.

在 Behcet 病的 GWAS 研究中，发现了 2 个新基因和 HLA-B*510101。在 Vogt-Koyanagi-Harada 病中，还发现了 HLA-DRB1*0405 和一些基因关联，并发现了 2 种新的人类腺病毒 (HAdV 53)。和54)。虾青素是一种类胡萝卜素，可显着增加脉络膜血流量。一种新的 NF-κB 阻滞剂也显示出对实验性葡萄膜视网膜炎的显着抑制作用。

项目成果

Evaluation of mixed infection cases with both herpes simplex virus types 1 and 2

• DOI: 10.1002/jmv.21154
• 发表时间: 2008-05-01
• 期刊: JOURNAL OF MEDICAL VIROLOGY
• 影响因子: 12.7
• 作者: Kaneko, Hisatoshi;Kawana, Takashi;Suzutani, Tatsuo
• 通讯作者: Suzutani, Tatsuo

Investigation of the association between the GLC3A locus and normal tension glaucoma in Japanese patients by microsatellite analysis.

• DOI: 10.2147/opth.s4727
• 发表时间: 2009
• 期刊: Clinical ophthalmology (Auckland, N.Z.)
• 作者: Kamio M;Meguro A;Ota M;Nomura N;Kashiwagi K;Mabuchi F;Iijima H;Kawase K;Yamamoto T;Nakamura M;Negi A;Sagara T;Nishida T;Inatani M;Tanihara H;Aihara M;Araie M;Fukuchi T;Abe H;Higashide T;Sugiyama K;Kanamoto T;Kiuchi Y;Iwase A;Ohno S;Inoko H;Mizuki N
• 通讯作者: Mizuki N

Behcet Disease in Children

• DOI: 10.3109/09273948.2011.555592
• 发表时间: 2011-04-01
• 期刊: OCULAR IMMUNOLOGY AND INFLAMMATION
• 影响因子: 3.3
• 作者: Atmaca, Leyla;Boyvat, Ayse;Gurler, Aysel
• 通讯作者: Gurler, Aysel

Anti-inflammatory effect of angiotensin type 1 receptor antagonist on endotoxin-induced uveitis in rats

• DOI: 10.1007/s00417-007-0730-2
• 发表时间: 2008-05
• 期刊: Graefe's Archive for Clinical and Experimental Ophthalmology
• 作者: A. Miyazaki;N. Kitaichi;Kazuhiro Ohgami;Daiju Iwata;X. Jin;K. Iwabuchi;T. Morohashi;S. Ohno;K. Onoé

Neuroprotective effect of geranylgeranylacetone against ischemia-induced retinal injury.

香叶基香叶基丙酮对缺血引起的视网膜损伤的神经保护作用。

• 发表时间: 2007
• 期刊: Molecular Vsion 13
• 作者: Namekata;K.;原田知加子;Namekata K.;Harada T.;Nakamura K.;楯川幸弘;Harada C.
• 通讯作者: Harada C.