Molecular approach to analyze strategies of pathogens in wildlife for acuierement of new host

分子方法分析野生动物病原体获取新宿主的策略

• 批准号: 11691164
• 负责人: SUGIMOTO Chihiro
• 金额: $ 7.49万
• 依托单位: Obihiro University of Agriculture and Veterinary Medicine (2000-2001)Hokkaido University (1999)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11691164/
• 关键词: Theileria; Babesia; Protozoan diseases; wildlife; phylogeny; herpesvirus; Rhodococcus; rRNA gene; 原虫; 馬ヘルペスウイルス; Rhodococcus equi; 住血原虫; Theileria; Babesia; Protozoan diseases; wildlife; phylogeny; herpesvirus; Rhodococcus; rRNA gene; 原虫; 馬ヘルペスウイルス; Rhodococcus equi; 住血原虫

Some of pathogens are communicable among humans, domesticated and wild animals and cause various diseases. In this study, we investigated protozoan, bacterial and vial pathogens from wild or domestic animals and their environment in order to determine whether they can acquire new host range by crossing biological and environmental barriers.Theileria parasite in ruminants are devided into highly pathogenic and apathogenic species. Wildlife harbor parasites of both categories, but they are not closely related to those from domestic animals on the basis of ribosomal RNA gene analysis. Rhodococcus equi with virulent plasmid are isolated from soil in horse farms, but the plasmid types are similar to those isolated in isolate from European horses. Therefore, pathogenic strains of R. equi may have been brought from Europe and colonized in soil in Africa. Herpesviruses were demonstrated in blood samples on 5 species of antelopes and rhinocerous. The isolate from impala is different from those isolated from domestic ruminants.Taken together, it is concluded that pathogens investigated in this study have been associated and coevolved with their original hosts, and that they are not easily able to acquire new host even under environments where wildlife and domestic animals are in close contact with each other.

一些病原体在人类，驯养和野生动物中具有传染性，并引起各种疾病。在这项研究中，我们调查了来自野生或家畜及其环境的原生动物，细菌和小瓶病原体，以确定它们是否可以通过越过生物学和环境障碍来获得新的宿主范围。反刍动物中的寄生虫被散布在高度的致病性和致病性物种中。野生动植物港口寄生虫两类的寄生虫，但根据核糖体RNA基因分析，它们与家畜的寄生虫没有密切相关。用毒力质粒从马农场中的土壤中分离出来，但质粒类型与与欧洲马分离的分离物相似。因此，R。Equi的致病菌株可能是从欧洲带来的，并在非洲的土壤中定植。在5种羚羊和鼻菌的血液样本中证明了疱疹病毒。从黑斑羚的分离物与从家庭反刍动物中分离出来的分离物不同。结论得出的结论是，在这项研究中研究的病原体已经与原始宿主相关联，并且与彼此之间野生动物和家畜密切接触的环境也无法轻易获得新宿主。