PFI-RP: Development of a Temperature-Sensitive, High-Adhesion Medical Tape for Reducing Pain, Skin Injury, and Dislodgement of Critical Devices for Children in Hospitals

PFI-RP：开发一种温度敏感、高粘性医用胶带，用于减轻医院儿童的疼痛、皮肤损伤和关键设备的移位

• 批准号: 2234356
• 负责人: Eric Seibel
• 金额: $ 55万
• 依托单位: University of Washington
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2234356&HistoricalAwards=false
• 关键词: PFI; RP; Development; Temperature; Sensitive

The broader impact/commercial potential of this Partnerships for Innovation – Research Partnerships (PFI-RP) project is reducing medical adhesive related skin injuries and device dislodgement events. Medical adhesives are used to secure wound care dressings and other critical devices to the skin. Although stronger adhesives can provide a higher level of securement, they are difficult to painlessly remove from the skin and may cause medical-adhesive-related skin injuries, which include skin tears and an increased risk of infection. This project will develop higher adhesion medical tapes, whereby the adhesion can be reduced for removal with the application of heat. This ability to remove easily will significantly reduce the risk of skin injury and subsequent infections while simultaneously providing the high adhesion required for secure attachment of medical devices during hospital care, reducing device dislodgement events and improving the quality of care. If successful, this solution will save over $1 billion annually in healthcare by preventing skin injury and critical device dislodgement. The project will train promising technical professionals in translational entrepreneurship with close mentorship from industry. The proposed project will provide a chemical and physical understanding of temperature responsive adhesives required for high adhesion medical tape that can avoid both skin injury during tape removal and accidental device dislodgement. Current medical tapes do not have a temperature sensitive component to enable higher adhesion coupled with easier release. Initial prototypes have demonstrated an adhesive tape with a substantial temperature-responsive release attribute. Fully understanding the mechanism for this release could impact the development of stimuli-responsive adhesives that could be used for a wide range of medical and nonmedical applications. The major goals of this project are the following: (a) gain a fundamental knowledge of the release mechanism, (b) transfer to a high-volume manufacturing process to demonstrate scaling feasibility, (c) verify these high-volume manufacturing prototypes retain performance after storage with several pilot studies, (d) gain approval for testing in a nearby children’s hospital, and (e) train promising professionals in entrepreneurship and translational team science. This project will facilitate the fabrication of prototypes in a high-volume manufacturing environment that will outperform the current state-of-the-art medical tapes. In addition, highly skilled emerging professionals will receive training in the transition from pilot to high-volume product manufacturing and packaging.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这种创新研究伙伴关系（PFI-RP）在陪审团和设备上的兴高采烈的伙伴关系的更广泛的影响/商业伙伴，他们很难从皮肤上痛苦地去除皮肤损伤，其中包括皮肤撕裂和捕获的感染风险。 。该项目将通过近距离培训工艺行业进行转化企业家的培训。最初的原型表现出具有大量温度的粘合剂。 （c）在释放机制缩放可行性中，（c）验证这些制造原型在存储后保持了严重试验研究后的保留性能，（d）获得附近儿童医院的测试批准，以及（e）培训有前途的企业家和翻译团队科学专业人士。该项目将促进在高批量制造环境中制造原型包装。该奖项反映了NSF'Sf'Stututory Mission，并通过使用Toe Toe Toe Toe Toe Toe Toe Toe的知识分子优点和更广泛的影响评论标准获得了值得支持的支持。