EAGER: Microendoscopy-Guided Biopsy in Very Small Ducts

EAGER：在非常小的导管中进行显微内窥镜引导活检

• 批准号: 1351110
• 负责人: Eric Seibel
• 金额: $ 30万
• 依托单位: University of Washington
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1351110&HistoricalAwards=false
• 关键词: EAGER; Microendoscopy; Guided; Biopsy; Very

Abstract#1351110Eric J. SeibelIn this EAGER project a new engineering design for an endoscopic medical device is proposed. This new approach will allow a working channel to be included within an ultrathin and flexible endoscope of 1.7-mm diameter. Instead of shrinking the conventional endoscope of separate channels for illumination, imaging, flushing, and biopsy; the new approach will place an ultrasmall imager at the tip of a working channel that provides flushing and biopsy. This new approach is transformative for clinical imaging and critically helpful for accelerating the development of optical biopsy. The working channel will provide the key requirements of fluid exchange and tissue vacuum, biopsy, and retrieval. Testing will involve the biopsy apparatus, which is suction of the epithelial mucosa into a cutting chamber that is connected to the proximal end for biopsy retrieval. The biopsy apparatus will be modified in an iterative manner using test results from a synthetic phantom and ex vivo pig lung. The integrated microendoscope and biopsy apparatus will be fabricated and tested for endoscopic guidance to specific sites for biopsy. Fluorescently labeled cells and microspheres will be injected into the luminal wall so that accuracy as well as adequacy of the biopsy will be the quantitative milestones.

摘要#1351110Eric J. Seibel 在这个 EAGER 项目中，提出了一种新的内窥镜医疗设备工程设计。 这种新方法将允许将工作通道包含在直径为 1.7 毫米的超薄柔性内窥镜中。不再缩小传统内窥镜的照明、成像、冲洗和活检的单独通道；新方法将在工作通道的顶端放置一个超小型成像仪，以提供冲洗和活检。这种新方法对临床成像具有变革性作用，对于加速光学活检的发展至关重要。 工作通道将提供液体交换和组织真空、活检和检索的关键要求。测试将涉及活检装置，该装置将上皮粘膜吸入连接到近端的切割室中以进行活检检索。活检装置将使用合成模型和离体猪肺的测试结果以迭代方式进行修改。集成的显微内窥镜和活检装置将被制造和测试，以用于内窥镜引导到特定部位进行活检。荧光标记的细胞和微球将被注射到管腔壁中，以便活检的准确性和充分性将成为定量的里程碑。