IDR-Collaborative: Quantitative 3D Optical Tomographic Microscopy for Lung Cancer Diagnosis

IDR-Collaborative：用于肺癌诊断的定量 3D 光学断层显微术

• 批准号: 1014976
• 负责人: Eric Seibel
• 金额: $ 31.65万
• 依托单位: University of Washington
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-15 至 2014-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1014976&HistoricalAwards=false
• 关键词: IDR; Collaborative; Quantitative; 3D; Optical

1014976SeibelA microscopic tool being developed by this team will allow quantitative absorption and fluorescence 3D imaging of cells and their organelles which can be correlated to the clinical standards of disease diagnosis for the first time. This project develops new fields of 3D quantitative microscopy in two important contrast modes that bridge a gap between clinical diagnosis and medical research. In addition, the technology of 3D image processing from quantitative CT imaging for disease diagnosis is being applied to microscopy in a unique collaboration.Textbooks of cell biology depict a cell as flat with two-dimensional features. If disease diagnosis is 3D and more quantitative and sensitive to disease onset, then these textbooks will likely change to more accurately represent the cell anatomy. Teaching students on cellular structures and functions may be significantly changed due to advancements of true 3D microscopy. Providing cytologists and molecular biologists with quantification tools will result in earlier diagnosis of lethal diseases like lung cancer and improved understanding of the disease mechanisms.

该团队开发的1014976圆锥形显微镜工具将使细胞及其细胞器的定量吸收和荧光3D成像首次与疾病诊断的临床标准相关。该项目在两种重要的对比模式下开发了3D定量显微镜的新领域，这些模式弥合了临床诊断和医学研究之间的差距。此外，在独特的协作中，从定量CT成像中进行的3D图像处理技术正在将其应用于显微镜。细胞生物学的文学书将细胞描绘成具有二维特征的细胞。如果疾病诊断是3D，并且对疾病发作更加敏感，那么这些教科书可能会更改为更准确地代表细胞解剖结构。由于真实的3D显微镜的进步，教学学生就细胞结构和功能进行了显着改变。 为细胞学家和分子生物学家提供定量工具，将导致早期诊断出肺癌等致命疾病，并提高对疾病机制的了解。