I-Corps: Natural Product-based, Mechanically-diverse Degradable Engineering Materials

I-Corps：基于天然产物的机械多样化可降解工程材料

• 批准号: 1645581
• 负责人: Karen Wooley
• 金额: $ 5万
• 依托单位: Texas A&M University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-15 至 2017-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1645581&HistoricalAwards=false
• 关键词: Corps; Natural; Product; based; Mechanically

The broader impact/commercial potential of this I-Corps project will be the use of degradable natural product-based materials for the reduction of pollution stemming from lost and discarded plastic goods in the environment. Natural product-based polycarbonates have significant potential environmental and societal impact, as they are made from natural products, reducing the dependency of polymeric materials on petroleum-based feedstocks. Another advantage of these polycarbonate materials is that upon degradation, they reproduce natural products and carbon dioxide, giving the potential for environmental resorption. The commercial potential of degradable polymer materials is extensive when they can be produced rapidly and have broadly-tunable mechanical properties, allowing for their use in a diverse range of commercial products, from disposable food containers to high performance engineering materials.This I-Corps project involves a safe, sustainable solution to the challenge of durable plastic materials that can foul and damage marine and other environments. This I-Corps technology involves the use of abundant natural products to produce polymer networks and composite materials having a range of physical and mechanical properties, and a programmed disintegration pathway. Synthetic strategies have been developed to transform glucose, quinic acid, and other natural products into multi-functional monomers that can be rapidly polymerized using photochemically- or thermally-initiated crosslinking to afford unique polycarbonate materials. Through the use of molds during crosslinking, these materials can be fabricated into many shapes and sizes. Polycarbonates with mechanical characteristics from a rubbery elastomer to a rigid plastic can be achieved by varying the crosslinking conditions. Hydrolytic degradation times can be tuned, depending on the crosslink density and hydrophilicity. These materials have also demonstrated no negative effects on the growth of cells. In summary, a combination of simple fabrication techniques and rapid, reliable chemistry can be employed to obtain a versatile and non-toxic natural family of materials with a breadth of physical and mechanical properties, generating commercial promise in a wide range of applications.

该I-Corps项目的更广泛的影响/商业潜力将是使用可降解的基于天然产品的材料来减少因环境中丢失和废弃的塑料商品而导致的污染。基于天然产品的聚碳酸酯具有由天然产物制成的显着潜在的环境和社会影响，从而减少了聚合物材料对石油基原料的依赖性。 这些聚碳酸酯材料的另一个优点是，降解后，它们会繁殖天然产物和二氧化碳，从而有可能获得环境吸收。 当可以快速生产并具有广泛可调的机械性能时，可降解的聚合物材料的商业潜力将很大涉及对耐用塑料材料的挑战的安全，可持续的解决方案，这些塑料材料可能会犯规并损害海洋和其他环境。 这种I-Corps技术涉及使用丰富的天然产品来生产具有一系列物理和机械性能的复合材料以及一个编程的瓦解途径。 已经开发出合成策略将葡萄糖，奎宁酸和其他天然产物转化为多功能单体，这些单体可以通过光化学或热启动的交联迅速聚合，以提供独特的聚碳酸酯材料。 通过在交联期间使用模具，这些材料可以成许多形状和尺寸。 可以通过改变交联条件来实现具有从橡胶弹性体到刚性塑料的机械特性的聚碳酸酯。 可以根据交联密度和亲水性来调整水解降解时间。 这些材料也表现出对细胞生长的负面影响。 总而言之，可以使用简单制造技术和快速，可靠的化学作用的组合来获得具有多种物理和机械性能的多功能和无毒的天然材料家族，从而在广泛的应用中产生了商业承诺。