DMREF: Collaborative Research: Interface-promoted Assembly and Disassembly Processes for Rapid Manufacture and Transport of Complex Hybrid Nanomaterials

DMREF：合作研究：用于快速制造和运输复杂混合纳米材料的界面促进的组装和拆卸过程

基本信息

批准号：
1629094
负责人：
Karen Wooley
金额：
$ 55.29万
依托单位：
Texas A&M University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2016
资助国家：
美国
起止时间：
2016-10-01 至 2021-09-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1629094&HistoricalAwards=false
关键词：
DMREF Collaborative Research Interface promoted

项目摘要

NON-TECHNICAL DESCRIPTION: The intimate combination of inorganic nanoparticles and organic polymers within nanoscopic packages of controlled sizes and shapes includes many challenges with the processes for their production and many opportunities for unique materials properties. Organic polymers are typically considered as plastics and they have physical and mechanical properties that allow them to serve common roles, such as elastic materials (clothing, tents, parachutes, etc.), containment vessels (cups, plastic bags, etc.), and high technology needs, such as optical materials (eye glasses, OLED devices, etc.), engineering materials (airplane parts, football helmets, etc.), among many others. Inorganic nanoparticles are typically rigid and often possess characteristics of magnetism, optical signaling or catalytic reactivity. This project will develop computational methods to guide approaches to rapidly discover and manufacture hybrid inorganic-organic nanostructured objects (HIONs) possessing complexity of compositions, structures, properties and functions. TECHNICAL DESCRIPTION: The primary hypothesis driving our project is that the contrasting interactions of polymers vs nanoparticles vs HIONs with each other and with surfaces and flow fields in porous media and other designed interfaces can be harnessed to develop methods for scalable production. The assembly of organic polymers or inorganic particles or their co-assembly is usually conducted in either the solution state or in the bulk. Although simulations have guided polymer and particle assembly processes, this research activity adds the complexity of assembly/disassembly in a flow field and in an adaptive resolution solvent(s) model, and will elucidate how interfaces impact assembly/disassembly. Experimentally, HION assembly/disassembly at solution-solid substrate interfaces in a flow system or at solvent-solvent interfaces represent new frontiers. Only recently has incorporation of discrete nanoscale heterogeneity on surfaces been demonstrated to allow quantitative mechanistic prediction of particle retention on unfavorable surfaces, as well as mechanistic prediction of release in response to perturbations in solution ionic strength and fluid velocity. Ultimately, the primary goal is to be able to conduct high throughput, tunable manufacturing of complex HIONs that exhibit compositions, structures, morphologies and properties for diverse technological applications.

非技术描述：无机纳米粒子和有机聚合物在尺寸和形状受控的纳米级封装内的紧密结合，在其生产过程中带来了许多挑战，也为独特材料性能带来了许多机会。有机聚合物通常被视为塑料，它们具有使它们能够发挥常见作用的物理和机械特性，例如弹性材料（衣服、帐篷、降落伞等）、密封容器（杯子、塑料袋等）和高技术需求，如光学材料（眼镜、OLED器件等）、工程材料（飞机零部件、橄榄球头盔等）等。无机纳米粒子通常是刚性的，并且通常具有磁性、光学信号或催化反应性的特征。该项目将开发计算方法来指导快速发现和制造具有复杂成分、结构、性质和功能的混合无机-有机纳米结构物体（HION）的方法。技术描述：推动我们项目的主要假设是，聚合物与纳米颗粒与 HION 之间以及与多孔介质和其他设计界面中的表面和流场之间的对比相互作用，可用于开发可扩展生产的方法。有机聚合物或无机颗粒的组装或它们的共组装通常在溶液状态或本体中进行。尽管模拟已经指导了聚合物和颗粒组装过程，但这项研究活动增加了流场和自适应分辨率溶剂模型中组装/拆卸的复杂性，并将阐明界面如何影响组装/拆卸。实验上，流动系统中溶液-固体基质界面或溶剂-溶剂界面的 HION 组装/拆卸代表了新的前沿。直到最近，表面上离散纳米级异质性的结合才被证明可以对不利表面上的颗粒保留进行定量机械预测，以及响应于溶液离子强度和流体速度的扰动而释放的机械预测。最终，主要目标是能够对复杂的 HION 进行高通量、可调的制造，这些 HION 具有适合不同技术应用的成分、结构、形态和特性。

项目成果

期刊论文数量（19）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Elucidation of Substantial Differences in Ring-Opening Polymerization Outcomes from Subtle Variation of Glucose Carbonate-Based Monomer Substitution Patterns and Substituent Types

DOI：
10.1021/jacs.3c03339
发表时间：
2023-07
期刊：
Journal of the American Chemical Society
影响因子：
15
作者：
Yidan Shen;Mingwan Leng;Yunchong Yang;Senthil K. Boopathi;Guorong Sun;K. Wooley
通讯作者：
Yidan Shen;Mingwan Leng;Yunchong Yang;Senthil K. Boopathi;Guorong Sun;K. Wooley

Erythrocyte-Membrane-Camouflaged Nanocarriers with Tunable Paclitaxel Release Kinetics via Macromolecular Stereocomplexation

DOI：
10.1021/acsmaterialslett.0c00044
发表时间：
2020-04
期刊：
影响因子：
0
作者：
Yen-Nan Lin;Mahmoud Elsabahy;Sarosh Khan;Fuwu Zhang;Yue Song;Mei Dong;Richen Li;J. Smolen;R. L
通讯作者：
Yen-Nan Lin;Mahmoud Elsabahy;Sarosh Khan;Fuwu Zhang;Yue Song;Mei Dong;Richen Li;J. Smolen;R. L

Theory-Guided Targeted Delivery of Nanoparticles in Advective Environmental Porous Media