Degradable Polycarbonates from Polyhydroxy Natural Products

来自多羟基天然产物的可降解聚碳酸酯

基本信息

批准号：
1057441
负责人：
Karen Wooley
金额：
$ 38.83万
依托单位：
Texas A&M Research Foundation
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2011
资助国家：
美国
起止时间：
2011-08-01 至 2014-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1057441&HistoricalAwards=false
关键词：
Degradable Polycarbonates Polyhydroxy Natural Products

项目摘要

In this project funded by the Macromolecular, Supramolecular and Nanochemistry Program of the Chemistry Division, Karen L. Wooley of Texas A&M University will design synthetic strategies for the development of polymer materials that originate from renewable resources, exhibit novel combinations of strength, toughness, and hydrolytic degradability, and undergo breakdown to biologically-beneficial or benign by-products. This project combines polyhydroxy natural products as the monomeric building blocks, and carbonates, found in common engineering materials, as the linkages. Hydrolytic degradation will produce the polyhydroxy compound plus carbon dioxide. Two classes of natural monomers, D-glucose and quinic acid, will be evaluated for the construction of polycarbonates, each of which will hydrolyze to carbon dioxide plus the saccharide or quinic acid, respectively. The physical, mechanical and stability properties will be tuned by the chemical compositions and structures, controlled by the advancement of synthetic methodologies by which to prepare such materials. The broader impacts involve (1) diverse and extensive education, training and recruiting of the next generation of chemists, who are capable in chemistry and engineering, (2) advances to synthetic polymer chemistry, and (3) the creation of novel materials that have the potential to positively impact society. Students/postdoctoral associates will be trained in synthetic organic and polymer chemistries of challenging polyhydroxy and carbohydrate-based systems, they will gain expertise in rigorous physicochemical and mechanical characterization, they will be exposed to engineering concepts, and they will gain an appreciation for the creation of materials for important environmental, biomedical and other applications.This work will produce polymer materials for use as engineering plastics that originate from natural sources, thereby reducing dependence on petrochemicals, and that later degrade into natural compounds, to promote biological and environmental clearance. These materials are designed with aspects of engineering-type construction materials from Nature (e.g. cellulose, chitin, etc.) that are degradable, resorbable and recyclable. Ultimately, these polymers could have the potential to replace common plastics and to be developed for high-end medical and orthopedic device applications.

在这个由化学系高分子、超分子和纳米化学项目资助的项目中，德克萨斯农工大学的 Karen L. Wooley 将设计用于开发源自可再生资源的聚合物材料的合成策略，这些材料表现出强度、韧性和韧性的新颖组合。水解降解性，并分解为生物有益或良性的副产物。该项目将多羟基天然产物作为单体结构单元，并以常见工程材料中的碳酸盐作为连接件。水解降解会产生多羟基化合物和二氧化碳。将评估两类天然单体，D-葡萄糖和奎尼酸，用于聚碳酸酯的构造，每种单体将分别水解成二氧化碳加糖或奎尼酸。物理、机械和稳定性性能将通过化学成分和结构进行调整，并由制备此类材料的合成方法的进步控制。更广泛的影响包括（1）对具有化学和工程学能力的下一代化学家进行多样化和广泛的教育、培训和招募，（2）合成聚合物化学的进步，以及（3）新型材料的创造对社会产生积极影响的潜力。学生/博士后将接受具有挑战性的多羟基和碳水化合物系统的合成有机和聚合物化学方面的培训，他们将获得严格的物理化学和机械表征方面的专业知识，他们将接触到工程概念，并对创造感到欣赏用于重要环境、生物医学和其他应用的材料。这项工作将生产用作工程塑料的聚合物材料，这些材料源自天然来源，从而减少对石化产品的依赖，并随后降解为天然化合物，以促进生物和环境清除。这些材料的设计借鉴了自然界的工程型建筑材料（例如纤维素、甲壳素等）的特点，具有可降解、可吸收和可回收的特点。最终，这些聚合物有可能取代普通塑料，并被开发用于高端医疗和骨科设备应用。