SusChEM: Resourceful Polymers Derived from Polyhydroxyl Natural Products

SusChEM：源自多羟基天然产物的资源丰富的聚合物

• 批准号: 1610311
• 负责人: Karen Wooley
• 金额: $ 70万
• 依托单位: Texas A&M University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-15 至 2022-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1610311&HistoricalAwards=false
• 关键词: SusChEM; Resourceful; Polymers; Derived; Polyhydroxyl

Organic polymer materials, commonly thought of as plastics, are of critical importance to every aspect of human life, from the clothes that we wear to the computers that we use to the tires on which we drive to the devices through which medicines are administered. Two key challenges with polymer materials are their production from petrochemical sources, which are non-renewable, and their persistence in the environment. To address these challenges, Professors Wooley, Darensbourg, and Dr. Sun of Texas A&M University are designing strategies to produce polymer materials from natural building blocks while also incorporating degradable linkages that regenerate those natural building blocks once the material has completed its useful lifetime. This project includes research and educational components to impact fundamental knowledge about polymer materials across the disciplines of chemistry and engineering. The research team is developing synthetic chemistry approaches to the production of a series of polycarbonates and polyphosphoesters that originate from renewable resources, exhibit novel chemical, physical and mechanical properties, and undergo hydrolytic breakdown to biologically-beneficial or benign by-products. In one direction, this project combines polyhydroxyl natural products as the monomeric building blocks and carbonates as the linkages. Hydrolytic degradation of the resulting polymers produces the polyhydroxyl compound plus carbon dioxide. In a second direction, phosphoester linkages are utilized, again borrowing from Nature, in phosphoesters commonly found in biological macromolecules, such as DNA or RNA. The research activities include 1) the synthesis of functional monomers from polyhydroxyl natural products, 2) the transformation of those monomers into linear, branched or crosslinked polymer materials by either step-growth condensation or chain-growth ring-opening polymerizations, 3) rigorous characterization studies to determine the compositions, structures, physicochemical and mechanical properties; and 4) the study of hydrolytic stabilities and degradation products.

有机聚合物材料（通常被认为是塑料）对人类生活的各个方面都至关重要，从我们穿的衣服到我们使用的计算机，再到我们行驶时使用的轮胎，再到用于给药的设备。聚合物材料面临的两个主要挑战是它们的生产来自不可再生的石化来源，以及它们在环境中的持久性。 为了应对这些挑战，德克萨斯农工大学的伍利教授、达伦斯堡教授和孙博士正在设计策略，利用天然构件生产聚合物材料，同时加入可降解的连接，一旦材料完成其使用寿命，即可再生这些天然构件。该项目包括研究和教育部分，以影响化学和工程学科中聚合物材料的基础知识。研究小组正在开发合成化学方法来生产一系列聚碳酸酯和聚磷酸酯，这些聚碳酸酯和聚磷酸酯源自可再生资源，具有新颖的化学、物理和机械性能，并经过水解分解生成对生物有益或良性的副产品。在一个方向上，该项目将多羟基天然产物作为单体结构单元和碳酸盐作为链接。 所得聚合物的水解降解产生多羟基化合物和二氧化碳。在第二个方向上，再次借鉴《自然》，在生物大分子（例如 DNA 或 RNA）中常见的磷酸酯中利用了磷酸酯键。研究活动包括 1) 从多羟基天然产物合成功能单体，2) 通过逐步增长缩合或链增长开环聚合将这些单体转化为线性、支化或交联聚合物材料，3) 严格表征研究以确定成分、结构、物理化学和机械性能； 4）水解稳定性和降解产物的研究。

项目成果

Construction of nanostructures in aqueous solution from amphiphilic glucose‐derived polycarbonates

• DOI: 10.1002/pola.29229
• 发表时间: 2018-09
• 期刊: Journal of Polymer Science Part A: Polymer Chemistry
• 作者: Shota Osumi;Simcha E. Felder;Hai Wang;Yen-Nan Lin;Mei Dong;K. Wooley

In Situ Production of Ag/Polymer Asymmetric Nanoparticles via a Powerful Light-Driven Technique

• DOI: 10.1021/jacs.9b10205
• 发表时间: 2019-12-18
• 期刊: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
• 影响因子: 15
• 作者: Li, Richen;Wang, Hai;Wooley, Karen L.
• 通讯作者: Wooley, Karen L.

Elucidation of Substantial Differences in Ring-Opening Polymerization Outcomes from Subtle Variation of Glucose Carbonate-Based Monomer Substitution Patterns and Substituent Types

• DOI: 10.1021/jacs.3c03339
• 发表时间: 2023-07
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Yidan Shen;Mingwan Leng;Yunchong Yang;Senthil K. Boopathi;Guorong Sun;K. Wooley

Erythrocyte-Membrane-Camouflaged Nanocarriers with Tunable Paclitaxel Release Kinetics via Macromolecular Stereocomplexation

• DOI: 10.1021/acsmaterialslett.0c00044
• 发表时间: 2020-04
• 作者: Yen-Nan Lin;Mahmoud Elsabahy;Sarosh Khan;Fuwu Zhang;Yue Song;Mei Dong;Richen Li;J. Smolen;R. L

Correction to “Regioisomeric Preference in Ring-Opening Polymerization of 3′,5′-Cyclic Phosphoesters of Functional Thymidine DNA Analogues”

校正功能性胸苷 DNA 类似物的 3-,5-环磷酸酯开环聚合中的区域异构体偏好-

• DOI: 10.1021/acsmacrolett.8b00117
• 发表时间: 2018
• 期刊: ACS Macro Letters
• 影响因子: 7.015
• 作者: Tsao, Yi-Yun Timothy;Smith, Travis H.;Wooley, Karen L.
• 通讯作者: Wooley, Karen L.