SusChEM: Resourceful Polymers Derived from Polyhydroxyl Natural Products

SusChEM：源自多羟基天然产物的资源丰富的聚合物

• 批准号: 1610311
• 负责人: Karen Wooley
• 金额: $ 70万
• 依托单位: Texas A&M University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-15 至 2022-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1610311&HistoricalAwards=false
• 关键词: SusChEM; Resourceful; Polymers; Derived; Polyhydroxyl; SusChEM; Resourceful; Polymers; Derived; Polyhydroxyl

Organic polymer materials, commonly thought of as plastics, are of critical importance to every aspect of human life, from the clothes that we wear to the computers that we use to the tires on which we drive to the devices through which medicines are administered. Two key challenges with polymer materials are their production from petrochemical sources, which are non-renewable, and their persistence in the environment. To address these challenges, Professors Wooley, Darensbourg, and Dr. Sun of Texas A&M University are designing strategies to produce polymer materials from natural building blocks while also incorporating degradable linkages that regenerate those natural building blocks once the material has completed its useful lifetime. This project includes research and educational components to impact fundamental knowledge about polymer materials across the disciplines of chemistry and engineering. The research team is developing synthetic chemistry approaches to the production of a series of polycarbonates and polyphosphoesters that originate from renewable resources, exhibit novel chemical, physical and mechanical properties, and undergo hydrolytic breakdown to biologically-beneficial or benign by-products. In one direction, this project combines polyhydroxyl natural products as the monomeric building blocks and carbonates as the linkages. Hydrolytic degradation of the resulting polymers produces the polyhydroxyl compound plus carbon dioxide. In a second direction, phosphoester linkages are utilized, again borrowing from Nature, in phosphoesters commonly found in biological macromolecules, such as DNA or RNA. The research activities include 1) the synthesis of functional monomers from polyhydroxyl natural products, 2) the transformation of those monomers into linear, branched or crosslinked polymer materials by either step-growth condensation or chain-growth ring-opening polymerizations, 3) rigorous characterization studies to determine the compositions, structures, physicochemical and mechanical properties; and 4) the study of hydrolytic stabilities and degradation products.

通常被认为是塑料的有机聚合物材料对人类生活的各个方面至关重要，从我们穿的衣服到我们使用的计算机到我们开车驱车到使用药物的设备的轮胎。聚合物材料面临的两个主要挑战是它们从不可再生的石化来源生产，并且它们在环境中的持久性。 为了应对这些挑战，德克萨斯A＆M大学的Wooley，Darensbourg教授和Sun博士正在设计策略，以生产自然构件中的聚合物材料，同时还结合了可降解的链接，一旦材料完成了其有用的寿命，可以再生这些自然建筑块。该项目包括研究和教育组成部分，以影响化学和工程学科的聚合物材料的基本知识。研究小组正在开发合成化学方法，用于生产一系列源自可再生资源，具有新颖的化学，物理和机械性能，并经历水解分解到生物学上或良性副产品的水解分解。在一个方向上，该项目将多羟基天然产物作为单体构建块和碳酸盐结合在一起。 所得聚合物的水解降解会产生多羟基化合物加二氧化碳。在第二个方向上，在生物大分子（例如DNA或RNA）中通常发现的磷酸植物中，利用了磷酸酯连接，再次从自然中借用。研究活动包括1）从多羟基天然产物中合成功能单体，2）这些单体通过阶级增长凝结或链增长环的聚合物转化为线性，分支或交联聚合物材料，3）严格的特性研究，以确定组成，结构，结构，物理，物理学和机制和机制和机制， 4）研究水解稳定性和降解产物。