Collaborative Research: Exotic Block Copolymer Nanoparticles through Hierarchical Solution Construction

合作研究：通过分层解决方案构建奇异嵌段共聚物纳米粒子

基本信息

批准号：
1309724
负责人：
Karen Wooley
金额：
$ 27.75万
依托单位：
Texas A&M University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2013
资助国家：
美国
起止时间：
2013-07-01 至 2017-06-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1309724&HistoricalAwards=false
关键词：
Collaborative Research Exotic Block Copolymer

项目摘要

TECHNICAL SUMMARY:This project is a collaboration between the University of Delaware and Texas A&M which aims to establish new experimental paradigms for the construction of novel, exotic nanoparticles. Protocols will be developed that direct block copolymer solution behavior through fine-tuning stagewise iterations of kinetic vs. thermodynamic control and the application of chemical modifications at desired stages. In addition, a new toolbox of block copolymer functionality will be formulated for solution construction of nanoparticles. New block copolymer chemistries will allow a) shell crosslinking, b) core crosslinking, c) shell degradation, d) core degradation, e) display of ligand functionality from shell of polymer nanoparticle, f) extension to polybases as hydrophilic blocks for complexation with multiacid molecules during kinetically controlled assembly, and g) new hydrophobic blocks for phase separation once trapped within internal domains of the nanoparticles due to kinetically controlled hierarchical assembly. New solvent mixing pathways will be used to develop kinetically-controlled assembly processes for trapping two or more different block copolymers into the same nanoparticle for local phase separation and multicompartment particle construction. Resultant multicompartment particles can then undergo additional assembly and/or synthetic steps in a hierarchical construction process towards arbitrary, asymmetric structure and future function.NON-TECHNICAL SUMMARY: This research will develop the ability of scientists to create particles on the nanoscale with unprecedented complexity in structure and function. Nature contains plenty of examples of complex nanostructures that display ornate shape and function, both beneficial (e.g. microtubules within cells, cell membranes) and deleterious (e.g. viruses). New methods of synthesizing large polymer molecules, combined with new methods for forcing these molecules together to produce nanostructures, will be sought and combined to make extraordinary synthetic nanostructures. With effort, the construction method to make these nanomaterials will be as routine as lithography is in making microprocessors and memories for modern electronics. Ideally, the final nanostructures will be as arbitrary in structure and useful as lithographically produced devices in the future. The students who perform this interdisciplinary research will gain a broad and deep knowledge of nanomaterials science and polymer chemistry. All students involved will spread this knowledge to pre-college students through K-12 activities that use the research to develop fun, interesting topics to promote their interest in science and technology.

技术摘要：该项目是特拉华大学和德克萨斯A＆M之间的合作，旨在为建造新颖的异国纳米颗粒建造新的实验范式。将开发协议，该方案通过动力学与热力学控制的微调阶段迭代以及在所需阶段的化学修改应用，通过微调阶段迭代次要迭代。此外，将制定一个新的块共聚物功能的工具箱，以解决纳米颗粒的溶液构造。新的块共聚物化学将允许a）贝壳交联，b）核心交联，c）壳降解，d）核心降解，e）e）从聚合物纳米颗粒的壳中显示配体功能动力学控制组装过程中的分子，g）由于动力学控制的层次组件，一旦被困在纳米颗粒的内部域内，用于相分离的新疏水块。新的溶剂混合途径将用于开发动力学控制的组装过程，以将两个或更多不同的块共聚物捕获到同一纳米颗粒中，以进行局部相分离和多区域粒子构造。然后，在层次结构的过程中，可以在层次结构过程中进行额外的组装和/或合成步骤，以进行任意，不对称结构和未来功能。没有技术摘要：这项研究将发展科学家在纳米级上在纳米级上创建颗粒的能力，并具有前所未有的复杂性。结构和功能。自然包含大量复杂纳米结构的示例，这些纳米结构显示出华丽的形状和功能，既有益（例如细胞内的微管，细胞膜）和有害的（例如病毒）。合成大型聚合物分子的新方法将寻求并组合起来迫使这些分子共同产生纳米结构的新方法，以制造非凡的合成纳米结构。通过努力，使这些纳米材料的施工方法与光刻在制作现代电子产品的微处理器和记忆方面一样常规。理想情况下，最终的纳米结构将在结构上同样任意，并且将来与画幅生产的设备有用。进行这项跨学科研究的学生将获得对纳米材料科学和聚合物化学的广泛知识。所有参与的学生都将通过K-12活动将这些知识传播给预科学生，这些活动利用研究来开发有趣，有趣的主题来促进他们对科学和技术的兴趣。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Magnetically-active Pickering emulsions stabilized by hybrid inorganic/organic networks

通过混合无机/有机网络稳定的磁活性皮克林乳液

DOI：
10.1039/c6sm01830k
发表时间：
2016
期刊：
Soft Matter
影响因子：
3.4
作者：
Flores, Jeniree A.;Jahnke, Ashlee A.;Pavia-Sanders, Adriana;Cheng, Zhengdong;Wooley, Karen L.
通讯作者：
Wooley, Karen L.

Minocycline and Silver Dual-Loaded Polyphosphoester-Based Nanoparticles for Treatment of Resistant Pseudomonas aeruginosa