I-Corps: Single Chip Intravascular and Intracardiac Ultrasound Imaging Systems

I-Corps：单芯片血管内和心内超声成像系统

• 批准号: 1517521
• 负责人: Levent Degertekin
• 金额: $ 5万
• 依托单位: Georgia Tech Research Corporation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-01-15 至 2016-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1517521&HistoricalAwards=false
• 关键词: Corps; Single; Chip; Intravascular; Intracardiac

Coronary heart disease is one of the leading causes of death in the US and some 60M people in the US alone have some form of heart disease. Therefore, a great need exists for the advancement of devices and procedures to diagnose, treat, and correct a wide variety of forms of heart disease. Procedures such as radio frequency (RF) ablation to correct arrhythmias, reopening of totally blocked arteries and trans-catheter valve replacement are prolonged and sometimes not successfully performed due to the difficulties in the guidance of catheter based diagnostic and therapeutic devices within the cardiovascular system. This I-Corps team has developed a miniature forward looking 3-D ultrasound imaging system which essentially provides a flashlight for cardiologist or surgeons to navigate through the vascular system and within the heart. The proposed technology is developed to address the unmet need in image guidance for complex interventional heart procedures.The device that invented provides meaningful, real-time anatomical information occurring within the structures of the heart, as well as coronary and peripheral veins and arteries in a three dimensional view. The device should allow a less practiced clinician the ability to achieve the same results as a very skilled surgeon in less time and with similar accuracy. It should also allow certain catheter based minimally invasive procedures such as recanalization of blocked arteries which were declined because of the limitations of present devices, to now be done and avoid the open heart surgery. In the long term, the technology has the potential to displace the current catheter based ultrasound imaging systems completely by providing equal or better performance at reduced cost since it will dramatically reduce the assembly and catheter cabling which are the main cost drivers.

冠状动脉疾病是美国的主要死亡原因之一，仅在美国，大约有6000万人就有某种形式的心脏病。因此，巨大的需求是诊断，治疗和纠正各种形式的心脏病的设备和程序的发展。诸如校正心律失常，重新开放完全阻塞的动脉和跨导管阀更换之类的程序（RF）消融等程序延长了，由于基于导管基于导管的诊断和治疗设备的困难，有时无法成功执行。这支I-Corps团队已经开发了一个微型前向外观的3D超声成像系统，该系统实质上为心脏病专家或外科医生提供了手电筒，以通过血管系统和心脏内部导航。提出的技术是为了满足对复杂介入心脏程序的图像指南的未满足需求。发明的设备提供了在心脏结构内发生的有意义的实时解剖信息，以及三维视图中的冠状动脉和外围静脉和动脉。该设备应允许较低的临床医生能够在更少的时间内和相似的精度获得与非常熟练的外科医生相同的结果。它还应该允许某些基于导管的最小侵入性程序，例如由于当前设备的局限性而被拒绝的阻塞动脉的重新定性，并避免进行开放性心脏手术。从长远来看，该技术有可能通过以降低成本提供相等或更好的性能来完全取代基于导管的超声成像系统，因为它将大大减少组装和导管电缆，这是主要的成本驱动因素。