I-Corps: Next Generation "MultiDot" Quantum Dots for Biological Imaging

I-Corps：用于生物成像的下一代“MultiDot”量子点

• 批准号: 1242394
• 负责人: Jessica Winter
• 金额: $ 5万
• 依托单位: Ohio State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1242394&HistoricalAwards=false
• 关键词: Corps; Next; Generation; MultiDot; Quantum

Fluorescent probes comprise a $3.1B market, with quantum dots (QDs) forming an increasing share. With photostability superior to that of fluorescent dyes QDs have made a significant impact in biomedical imaging. However, despite their success, customers have identified three limitations in QD use: (1) insufficient brightness, (2) instability in harsh environments, particularly exposure to UV or laser illumination typical of many biological experiments, and (3) "blinking", an intermittent loss of fluorescence that limits application in single molecule tracking. The MultiDot technology, developed at Ohio State University under 4 separate NSF grants, can potentially address these challenges. MultiDots are composite QDs, similar in size to commercial QDs, but displaying 5 times the brightness, dramatically increased stability, and reduced blinking compared to commercial particles. The MultiDot has significant commercial potential, most notably in the biomedical imaging and diagnostic point-of-care test markets, which offer initial market entry points. The primary outcome of the I-Corps program will be market research and product development toward those markets, with the goal of (1) a go/no go decision, and if applicable, (2) identification of minimum customer-desired features and development and testing of a product with those features and (3) development of a business plan for appropriate markets. Because the MultiDots can be seamlessly substituted for QD competitors, it is anticipated that MultiDots could enter the market within a year. Additionally, this research will permit critical validation experiments to be performed that will enhance licensing potential. If successful, this research will not only advance the commercialization of the MultiDot technology, but will also provide a new method of large scale nanomanufacturing that can potentially be applied to other nanocomposites.

荧光探针构成了一个$ 3.1B的市场，量子点（QD）构成了越来越多的份额。具有优于荧光染料的光稳定性对生物医学成像产生了重大影响。但是，尽管他们取得了成功，但客户在QD使用方面已经确定了三个限制：（1）亮度不足，（2）在恶劣的环境中，尤其是许多生物学实验中典型的紫外线或激光照明的不稳定性，（3）“闪烁”，是荧光的间歇性损失，限制了在单个分子轨迹中的应用。在4个单独的NSF赠款下，在俄亥俄州立大学开发的多胎技术可以解决这些挑战。多站是复合QD，大小与商业QD相似，但与商业颗粒相比，亮度显示出亮度的5倍，稳定性急剧提高以及闪烁减少。多局部具有巨大的商业潜力，最值得注意的是在生物医学成像和诊​​断点测试市场中提供了初始市场入口点。 I-Corps计划的主要结果将是针对这些市场的市场研究和产品开发，目标是（1）GO/NO GO决策，如果适用，（2）识别最低限度的客户功能以及具有这些功能的产品的开发和测试，以及（3）为适当市场开发商业计划。由于可以将多人无缝代替QD竞争对手，因此预计多人可以在一年内进入市场。此外，这项研究将允许进行关键的验证实验，以提高许可潜力。 如果成功的话，这项研究不仅将推进多局技术的商业化，而且还将提供一种新的大规模纳米制造方法，可以可能应用于其他纳米复合材料。