Colorado Clinical and Translational Sciences Institute (CCTSI)

科罗拉多临床与转化科学研究所 (CCTSI)

• 批准号: 10764161
• 负责人: JANINE A HIGGINS
• 金额: $ 772.27万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2030-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10764161
• 关键词: Abbreviations; Acceleration; Address; Adult; Advisory Committees; Applications Grants; Authorization documentation; Biomedical Research; Biometry; COVID-19 pandemic; Center for Translational Science Activities; Child; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Colorado; Communities; Contracts; Data Science; Discipline of Nursing; Diverse Workforce; Education; Effectiveness; Electronic Health Record; Environment; Epidemiology; Equity; Evaluation; Exposure disparity; Faculty; Funding; Funding Opportunities; Future; Goals; Grant; Health; Health Alliance; Health system; Healthcare; Hospitals; Ice; Informatics; Infrastructure; Innovation Corps; Institution; Institutional Review Boards; Jews; Lead; Maps; Maternal and Child Health; Medical; Medical center; Mentored Clinical Scientist Development Program; Mentors; Methodology; Minority Groups; Monitor; Outcomes Research; Patient Care; Pediatric Hospitals; Performance; Pharmacologic Substance; Pharmacy Schools; Play; Process; Program Development; Public Health; Public Health Informatics; Public Health Schools; Reduce health disparities; Research; Research Design; Research Personnel; Research Support; Research Training; Review Committee; Role; Rural Community; Rural Population; Safety; School Dentistry; Science; Site; Special Population; System; TNFSF15 gene; Technology; Time; Training; Training Programs; Translating; Translational Research; Translations; Underserved Population; United States Department of Veterans Affairs; United States National Institutes of Health; Universities; Vision; Workforce Development; authority; career development; clinical translation; collaborative environment; college; community based participatory research; community center; community engagement; community organizations; community partnership; data sharing; design; electronic data; health data; health disparity; health inequalities; improved; innovation; medical schools; minority communities; next generation; pandemic disease; pre-doctoral; process improvement; programs; public health emergency; resilience; response; skills; success; translational impact; translational scientist

PROJECT SUMMARY/ABSTRACT Funded by NIH in 2008, 2013 and 2018, the Colorado Clinical and Translational Sciences Institute (CCTSI) at the University of Colorado Denver (CU Denver) has transformed the clinical and translational research and training enterprise in the Colorado region with the vision of accelerating the translation of discoveries into improved, equitable patient care and public health for all. The CCTSI, headquartered at the CU Anschutz Medical Campus, is a partnership of CU Denver, CU Boulder, Colorado State University (CSU), 5 hospital systems and 20 community organizations, which has advanced translational science by educating a diverse workforce, creating a collaborative environment that supports local and multi-site research, engaging communities through its unique community engagement program, creating methodologies that support research in special populations, and greatly enhancing our informatics and data science capabilities. The CCTSI infrastructure played a critical role in the Colorado response to the COVID pandemic and led to new innovations in research processes and implementation, while recognizing the health inequities and disparities exposed by the pandemic in rural, minority and underserved populations in Colorado. Despite the successes, there remain many challenges to overcoming inefficiencies and roadblocks in clinical translational science (CTS) processes locally and nationally and in reducing health disparities and inequities. This application maps our collaborative path forward to meet these challenges. In the next grant cycle, we will enhance our efforts to improve efficiency and coordination with Partners and across the CTSA Consortium, reinforce our extensive community partnerships, develop innovative informatics and technology solutions to advance CTS, and develop a diverse highly-skilled translational workforce for the future. This UM1 will be tightly coordinated with our other 6 CTSA grant applications, to accomplish the following 6 Overall Strategic Goals: Goal 1: Advance CTS by developing, demonstrating, and disseminating innovative programs to improve the efficiency and impact of translation across the entire T0.5 to T4 spectrum. Goal 2: Promote collaboration, team and data science, and partnerships to accelerate CTS locally, regionally and nationally. Goal 3: Partner locally, regionally and nationally with institutions, stakeholders and communities to develop innovative research programs that will address health inequities and disparities. Goal 4: Further develop operational efficiencies to enhance the quality, safety, efficiency, effectiveness and informativeness of clinical research. Goal 5: Promote a nimble research environment that can rapidly respond to urgent public health needs. Goal 6: Develop and disseminate CTS training programs that educate and sustain a resilient, diverse team of clinical research professionals and investigators. Special efforts will be made to enhance diversity in our workforce. Progress will be monitored and improved by our Evaluation Core and CQI program and we will make mid-course corrections as needed to achieve these goals and ultimately improve the health of our state and the nation.

项目摘要/摘要 由NIH于2008年，2013年和2018年资助，科罗拉多州的临床和转化科学学院（CCTSI） 科罗拉多大学丹佛分校（CU丹佛）改变了临床和转化研究， 在科罗拉多州培训企业，以加速发现转化为 所有人都改善，公平的患者护理和公共卫生。 CCTSI总部位于Cu Anschutz医疗 校园是Cu Denver，Cu Boulder，科罗拉多州立大学（CSU），5个医院系统和 20个社区组织，通过教育多样化的劳动力来提高转化科学， 创建一个协作环境，以支持本地和多站点研究，通过 它独特的社区参与计划，创建了支持特殊研究的方法论 人群，并大大增强了我们的信息学和数据科学能力。 CCTSI基础架构 在科罗拉多州对COVID大流行的反应中起着至关重要的作用，并导致了研究的新创新 流程和实施，同时认识到大流行的健康不平等和差异 在科罗拉多州的农村，少数民族和服务不足的人口。尽管取得了成功，但仍有很多 克服临床转化科学（CTS）过程中的低效率和障碍的挑战 在本地和全国范围内以及减少健康差异和不平等。此应用程序映射我们的 协作途径可以满足这些挑战。在下一个赠款周期中，我们将加强我们的努力 提高与合作伙伴以及整个CTSA联盟的效率和协调，加强了我们的广泛 社区合作伙伴关系，开发创新的信息学和技术解决方案，以推进CTS并开发 未来的多样化的高技能翻译员工队伍。这个UM1将与我们的其他 6个CTSA赠款申请，以实现以下6个总体战略目标：目标1：提前CTS 制定，展示和传播创新计划，以提高 整个T0.5到T4频谱的翻译。目标2：促进协作，团队和数据科学以及 在本地，区域和全国加速CTS的合作伙伴关系。目标3：在本地，地区和全国范围内合作伙伴 与机构，利益相关者和社区一起制定创新研究计划，以解决健康 不平等和差异。目标4：进一步发展运营效率以提高质量，安全性， 临床研究的效率，有效性和信息性。目标5：促进灵活的研究 可以快速响应紧急公共卫生需求的环境。目标6：开发和传播CTS 培训计划，教育和维持一个有韧性的临床研究专业人员团队， 调查人员。将做出特别的努力来增强我们的员工多样性。进度将受到监控，并 通过我们的评估核心和CQI计划改进，我们将根据需要进行中课程校正 实现这些目标，并最终改善我们国家和国家的健康。

项目成果

High magnitude exposure to repetitive head impacts alters female adolescent brain activity for lower extremity motor control.

剧烈的重复性头部撞击会改变女性青少年下肢运动控制的大脑活动。

• DOI: 10.1016/j.brainres.2024.148785
• 发表时间: 2024
• 期刊: Brain research
• 影响因子: 2.9
• 作者: Zuleger,TaylorM;Slutsky-Ganesh,AlexisB;Grooms,DustinR;Yuan,Weihong;BarberFoss,KimD;Howell,DavidR;Myer,GregoryD;Diekfuss,JedA
• 通讯作者: Diekfuss,JedA