ENERGY VALUE OF RESISTANT STARCH

抗性淀粉的能量值

• 批准号: 7719453
• 负责人: JANINE A HIGGINS
• 金额: $ 0.3万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719453
• 关键词: Calories; Carbohydrates; Cholesterol; Communities; Computer Retrieval of Information on Scientific Projects Database; Consumption; Cross-Over Studies; Diet; Double-Blind Method; Fatty acid glycerol esters; Female; Fermentation; Food; Funding; Future; Gastrointestinal tract structure; Grant; Health Benefit; In Vitro; Ingestion; Institution; Intake; Large Intestine; Metabolism; Outcome Measure; Outcome Study; Placebo Control; Plasma; Randomized; Recruitment Activity; Research; Research Design; Research Personnel; Resistance; Resources; Satiation; Source; Starch; Testing; Triglycerides; United States National Institutes of Health; Volatile Fatty Acids; design; drinking; improved; in vivo; insulin sensitivity; male; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Resistant starch (RS) is any starch that is not fully digested and absorbed in the upper digestive tract. RS, therefore, passes to the large bowel where it is a substrate for fermentation to short chain fatty acids (SCFA). RS intake is associated with several changes in metabolism which may confer some health benefits. RS intake seems to decrease postprandial glycemic and insulinemic responses, lower plasma cholesterol and triglyceride concentrations, improve whole body insulin sensitivity, increase satiety, and reduce fat storage. However, studies designed to test these effects using RS diets are confounded by the fact that all of the calories from RS are not absorbed. Although the RS fraction of a starch can be determined in vitro, thereby facilitating calculation of availbale carbohydrate and the energy value of the starch, these values do not necessarily correspond to the in vivo energy value of the starch. Thus, it is necessary to investigate the energy value of RS in vivo. By determining the energy value of RS in vivo, meals and diets for future RS studies can be designed more accurately and the outcome of these studies will be easier to interpret by eliminating a major confounding factor. This study endeavors to test the ideas that: i) resistant starch (RS) is not fully absorbed and digested following ingestion ii) the energy of content of RS is less than the energy value for available carbohydrates A total of 15 subjects, male and female, will be recruited from the community and the UCHSC campus. The study will be a randomized, double blinded, cross-over trial. Each subject will consume three starch drinks of different RS content in random order thereby acting as his/her own control. We wish to compare the effects of RS consumption directly with digestible strach consumption so no control/placebo group will be used. The primary outcome measure is the thermic effect of food in response to each starch which will be used to calculate the total caloric value of each starch.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 抗性淀粉（RS）是任何未完全消化并吸收在上层消化道中的淀粉。 因此，RS传递到大肠，在那里它是发酵对短链脂肪酸（SCFA）的底物。 RS摄入量与代谢的几种变化有关，这些变化可能带来一些健康益处。 RS摄入量似乎降低了餐后血糖和胰岛素反应，较低的血浆胆固醇和甘油三酸酯浓度，提高全身胰岛素敏感性，提高饱腹感并减少脂肪储存。 但是，旨在使用RS饮食来测试这些影响的研究使得不吸收RS的所有卡路里都混淆了。 尽管可以在体外确定淀粉的RS分数，从而促进含有碳水化合物的计算和淀粉的能量值，但这些值不一定与淀粉的体内能量值相对应。 因此，有必要研究体内RS的能量值。 通过确定体内RS的能量价值，可以更准确地设计用于未来RS研究的餐食和饮食，并且通过消除主要的混杂因素，这些研究的结果将更容易解释。 这项研究努力测试： i）摄入后，耐药淀粉（RS）未完全吸收和消化 ii）RS的含量能量小于可用碳水化合物的能量值 总共将从社区和UCHSC校园中招募15名男性和女性。 该研究将是一项随机，双眼的跨界试验。 每个主题将以随机顺序消费三种不同RS含量的淀粉饮料，从而充当自己的控制。 我们希望将RS消耗的影响直接与消化率的Strach消耗进行比较，以便不使用控制/安慰剂组。 主要结果度量是食物对每个淀粉的热效应，该淀粉将用于计算每个淀粉的总热量。