RESISTANT STARCH: A POTENTIAL WEIGHT LOSS AIDE IN CHILDREN?

抗性淀粉：儿童减肥的潜在助手？

• 批准号: 7605097
• 负责人: JANINE A HIGGINS
• 金额: $ 1.7万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605097
• 关键词: Adolescent; Adult; Body Weight decreased; Carbohydrates; Child; Cholesterol; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Diet; Dyslipidemias; Fatty acid glycerol esters; Fermentation; Funding; Grant; Health Benefit; Individual; Ingestion; Institution; Insulin Resistance; Intake; Large Intestine; Metabolic; Metabolism; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Plasma; Production; Property; Research; Research Personnel; Resistance; Resources; Satiation; Small Intestines; Source; Starch; Thinking; Triglycerides; United States National Institutes of Health; Volatile Fatty Acids; absorption; disorder prevention; improved; insulin sensitivity; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. While there is strong evidence that the amount and type of fat in the diet can have dramatic effects on metabolism, the case for carbohydrate subtypes influencing metabolic parameters is emerging. By definition, resistant starch (RS) is any starch that is not digested in the small intestine but passes to the large bowel. Here, RS is a good substrate for fermentation which gives rise to an increase in short chain fatty acid production. This difference in absorption between RS and digestible starch is thought to denote their differential metabolic responses. RS intake is associated with several changes in metabolism which may confer some health benefits. In adults, RS intake seems to decrease postprandial glycemic and insulinemic responses, lower plasma cholesterol and triglyceride concentrations, improve whole body insulin sensitivity, increase satiety, and reduce fat storage. These properties make RS an attractive dietary target for the prevention of diseases associated with dyslipidemia and insulin resistance as well as the development of weight loss diets and dietary therapies for the treatment of Type 2 diabetes. However, there is no data currently available on the metabolic effects of RS ingestion in obese individuals or children/adolescents.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 尽管有充分的证据表明，饮食中脂肪的数量和类型可能会对代谢产生巨大影响，但影响代谢参数的碳水化合物亚型的情况正在出现。 根据定义，抗性淀粉（RS）是在小肠中没有消化但可以传递到大肠的任何淀粉。 在这里，RS是发酵的良好底物，可导致短链脂肪酸产生的增加。 RS和易消化淀粉之间的吸收差异被认为表示它们的差异代谢反应。 RS摄入量与代谢的几种变化有关，这些变化可能带来一些健康益处。 在成年人中，RS摄入量似乎会降低餐后血糖和胰岛素反应，降低血浆胆固醇和甘油三酸酯的浓度，提高全身胰岛素敏感性，提高饱腹感并减少脂肪储存。 这些特性使RS成为预防与血脂异常和胰岛素抵抗相关的疾病的吸引力饮食靶标，以及减肥饮食和饮食疗法的发展，用于治疗2型糖尿病。但是，目前尚无有关肥胖个体或儿童/青少年摄入量的代谢作用的数据。