SNM: Continuous, Large-Scale Nanocomposite Production Via Micellular Electrospray

SNM：通过胶束电喷雾连续、大规模生产纳米复合材料

• 批准号: 1344567
• 负责人: Jessica Winter
• 金额: $ 117.41万
• 依托单位: Ohio State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2017-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1344567&HistoricalAwards=false
• 关键词: SNM; Continuous; Large; Scale; Nanocomposite

This grant provides funding to establish new methods and equipment to produce nanocomposites for biomedical applications at increased volume for direct translation to industry. This new synthesis method will combine electrospray, a top-down, continuous spraying process, with self-assembly, a bottom-up process that occurs spontaneously. Three equipment configurations will be examined to optimize the ratio of particle formation speed (i.e., kinetics) to particle quality (i.e., thermodynamics). This process will be developed in collaboration with experts in science communication to ensure that appropriate societal, ethical, and environmental health and safety considerations are integrated into the process design as it is being developed. The results of this process will be evaluated in two industrial test-beds focusing on biomedical imaging and separations.If successful, this research will addresses critical roadblocks in nanocomposite commercialization by providing a continuous manufacturing strategy for nanocomposite formation. Because electrospray droplet morphology is tightly controlled, this method should enable greater process control and improved particle uniformity, reproducibility, and scale. This research will study three nanocomposites with strong commercialization potential: composite magnetic nanoparticles, composite quantum dots (QDs), and magnetic QDs, which have potential applications in biomedical imaging, clinical diagnostics, and pharmaceutical separations. However, this approach could be used to manufacture composites containing any hydrophobic components smaller than the nanocontainer, and could thus impact a diverse range of fields including electronics, optics, and energy. Broad sharing of our endeavor to safely commercialize new nanocomposite products will be undertaken by two outstanding non-profit educational partners: Edheads, award-winning education web game producers, and the Museum of Science, Boston, lead of the NSF Nanoscale Informal Science Education (NISE) Network.

该赠款为建立新的方法和设备提供了资金，以生产纳米复合材料，以增加数量的生物医学应用，以直接转化为行业。这种新的合成方法将将电喷雾（一种自上而下的连续喷涂过程与自组装）结合在一起，这是自发发生的自下而上的过程。将检查三种设备配置，以优化颗粒形成速度（即动力学）与粒子质量（即热力学）的比率。该过程将与科学传播专家合作开发，以确保在开发过程中将适当的社会，道德和环境健康和安全考虑因素整合到过程设计中。这一过程的结果将在两个以生物医学成像和分离为重点的工业测试床中进行评估。如果成功，该研究将通过为纳米复合材料形成的连续制造策略来解决纳米复合商业化的关键障碍。由于电喷雾液滴形态受到严格控制，因此该方法应实现更大的过程控制和改善颗粒均匀性，可重复性和比例。这项研究将研究具有强大商业化潜力的三种纳米复合材料：复合磁性纳米颗粒，复合量子点（QD）和磁QD，它们在生物医学成像，临床诊断和药物分离中具有潜在的应用。但是，这种方法可用于制造含有小于纳米核心的任何疏水成分的复合材料，因此可能会影响包括电子，光学和能量在内的各种领域。我们的努力的广泛分享将由两个杰出的非营利性教育合作伙伴进行：EDHEADS，屡获殊荣的教育网络游戏生产商和波士顿博物馆，NSF纳米级非正式科学教育（NISE）网络的负责人。