Micellular Electrospray Synthesis of Magnetic Quantum Dots

磁性量子点的胶束电喷雾合成

• 批准号: 1206745
• 负责人: Jessica Winter
• 金额: $ 33万
• 依托单位: Ohio State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2016-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1206745&HistoricalAwards=false
• 关键词: Micellular; Electrospray; Synthesis; Magnetic; Quantum; Micellular; Electrospray; Synthesis; Magnetic; Quantum

ID: MPS/DMR/BMAT(7623) 1206745 PI: Winter, Jessica ORG: Ohio State UniversityTitle: Micellular Electrospray Synthesis of Magnetic Quantum DotsINTELLECTUAL MERIT: This research will examine new synthesis routes to unite quantum dots and magnetic nanoparticles. These magnetic quantum dots are fluorescent and respond to a magnetic field and could thus be used in a variety of applications, including multimodal imaging, separations, and studies of the role of force in cell function. These nanocomposites will be produced by combining a bottom up assembly strategy (micellular self-assembly) with a top down process (electrohydrodynamic spraying). In the proposed approach, electrospray will generate continuous, uniform, large surface area emulsion droplets that will be transformed to micelles via their interfacial instability with water. Because the morphology of electrospray particles is tightly controlled, micellular electrospray should enable greater process control and improved particle uniformity, reproducibility, and scale. Given that electrospray has not previously been used to examine micellular structures, we will first explore the influence of reaction conditions on empty micelle production, and then investigate the influence of nanoparticle loading on micelles. Particles produced will be characterized through single nanocomposite analysis techniques. Single particle magnetic characterization at the nanoscale has not previously been demonstrated. This approach could be applied to virtually any hydrophobic structure smaller than the micelle core, thus producing a wide variety of nanocomposites. These studies will also increase understanding of micelle-nanoparticle assemblies, which are distinct from empty micelles or micelles encapsulating molecules.BROADER IMPACTS: This research will be executed by diverse teams of graduate, undergraduate, and high school researchers. Research results will be disseminated through a unique educational strategy that combines teaching and outreach to develop course materials and experimental demonstrations for K-14 students. Additionally, the proposed work will be incorporated into an educational video game developed by non-profit partner EdHeads to increase K-12 STEM and nanotechnology awareness.

ID：MPS/DMR/BMAT（7623）1206745 PI：冬季，Jessica Org：俄亥俄州立大学Title：磁性量子量子元素的合成胶结量质量智能功能：这项研究将检查新的合成途径以统一量子点和磁性纳米机构。 这些磁量子点是荧光的，并且对磁场响应，因此可以用于多种应用，包括多模式成像，分离和力在细胞功能中的作用。 这些纳米复合材料将通过将自下而上的组装策略（胶束自组装）与自上而下的过程（电水动力学喷涂）相结合来产生。 在建议的方法中，电喷雾将产生连续的，均匀的大表面积乳液液滴，这些液滴将通过其与水的界面不稳定性转化为胶束。 由于电喷雾颗粒的形态受到严格控制，因此胶束电喷雾应实现更大的过程控制并改善颗粒均匀性，可重复性和比例。 鉴于电喷雾以前尚未用于检查胶束结构，我们将首先探讨反应条件对空胶束产生的影响，然后研究纳米颗粒载荷对胶束的影响。 产生的颗粒将通过单纳米复合材料分析技术来表征。 以前尚未证明在纳米级处的单个颗粒磁性表征。 这种方法几乎可以应用于小于胶束核的任何疏水结构，从而产生多种纳米复合材料。 这些研究还将增加对胶束纳米颗粒组件的了解，这些胶束纳米颗粒的组件与封装分子的空胶束或胶束不同。Broader的影响：这项研究将由多元化的研究生，本科和高中研究人员执行。 研究结果将通过独特的教育策略来传播，该策略结合了教学和外展，以开发课程材料和为K-14学生开发实验演示。 此外，拟议的工作将纳入由非营利合作伙伴Edheads开发的教育视频游戏中，以提高K-12 STEM和纳米技术的意识。