Scalable Nanomanufacturing of Uniform Inorganic Nanoparticles Using Jet-Mixing Reactors

使用喷射混合反应器大规模纳米制造均匀无机纳米粒子

• 批准号: 2111412
• 负责人: Jessica Winter
• 金额: $ 73.35万
• 依托单位: Ohio State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2111412&HistoricalAwards=false
• 关键词: Scalable; Nanomanufacturing; Uniform; Inorganic; Nanoparticles

Nanoparticles have unique optical, magnetic, electronic, and catalytic properties that could lead to advances in computing, energy storage, chemical manufacturing, and healthcare. However, for those advances to be realized, nanoparticle syntheses must be translated from small laboratory-scale batch processes to commercial scale manufacturing processes. There have been several advances in continuous manufacturing of polymer nanoparticles; however, inorganic nanoparticles (i.e., metals, semiconductors, ceramics) are more difficult to manufacture because they often require high temperatures and inert environments. This award develops a high temperature and/or air-free scalable nanomanufacturing process for inorganic nanoparticles using catalyst and semiconductor quantum dots as model systems. These materials have high commercial potential (market capitalization of more than $1 billion per year) and are applied across industry sectors from healthcare to electronics. These materials have import for national security and global leadership because they are used in new kinds of computing important for American competitiveness, such as spintronics and quantum computing. This work also trains a diverse workforce for emerging careers in scalable nanomanufacturing with input from companies engaging in scale up processes. This research addresses a critical need for scalable processes for manufacturing inorganic nanoparticles. Currently, many of these materials are manufactured in batch processes that limit nanoparticle uniformity, and thus control of their size-dependent properties. Building upon successful polymer nanoparticle synthesis in jet mixing reactors via a nanoprecipitation route, this research develops inorganic (metal, semiconductor) nanoparticle manufacturing in air-free and/or high temperature jet-mixing reactors and provides accompanying scaling laws for their scale-up. As model systems the project studies CdS, MnS, and PbS quantum dots and Cu alloy catalysts, which are oxygen sensitive, require high temperatures for synthesis, or exhibit different morphologies depending on temperature. Concurrently, the project develops methods to integrate jet-mixing reactors in series to enable manufacture of core-shell nanoparticles composed of different materials. Such hybrid materials offer potential for multifunctionality or tunable properties. Currently, hybrid nanoparticles are manufactured in batch systems that are difficult to scale. This work also investigates methods of thermal control using fluid flow (as opposed to external heating and cooling) to enable rapid control in high temperature manufacturing processes. This is accomplished by interdisciplinary interactions within the team of experts in reactor design, nanoparticle synthesis, COMSOL modeling, and nucleation and growth theory. The project advances knowledge in the understanding and control of continuous scalable nanomanufacturing technologies.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

纳米颗粒具有独特的光学，磁性，电子和催化性能，可能会导致计算，储能，化学制造和医疗保健方面的进步。但是，要实现这些进步，纳米颗粒合成必须从小型实验室规模的批处理过程转换为商业规模的制造过程。连续生产聚合物纳米颗粒已经取得了一些进步。但是，无机纳米颗粒（即金属，半导体，陶瓷）更难制造，因为它们通常需要高温和惰性环境。该奖项使用催化剂和半导体量子点作为模型系统开发了无机纳米颗粒的高温和/或无空气可扩展的纳米制造过程。这些材料具有较高的商业潜力（每年的市值超过10亿美元），并且在从医疗保健到电子产品的行业领域都应用。这些材料具有国家安全和全球领导力的进口，因为它们用于新型计算中对美国竞争力很重要的计算，例如Spintronics和Quantum Computing。这项工作还培训了各种各样的劳动力，可以为新兴职业提供可扩展的纳米制造，并从参与规模化流程的公司的意见中培训了劳动力。这项研究解决了对生产无机纳米颗粒的可扩展过程的关键需求。当前，其中许多材料都是在限制纳米颗粒均匀性的批处理过程中制造的，从而控制了其尺寸依赖性特性。在通过纳米沉淀途径中的喷气混合反应器中成功的聚合物纳米颗粒合成的基础上，这项研究在无空气和/或高温喷射混合反应器中开发了无机（金属，半导体）纳米颗粒制造，并为其规模提高提供了伴随的尺度定律。作为模型系统，项目对氧气敏感的CD，MN和PBS量子点和Cu合金催化剂进行研究，需要高温才能合成，或者根据温度表现出不同的形态。同时，该项目开发了将喷射混合反应器串联集成的方法，以使其能够制造由不同材料组成的核心纳米颗粒。这种混合材料为多功能性或可调节性能提供了潜力。当前，混合纳米颗粒是在难以扩展的批处理系统中制造的。这项工作还研究了使用流体流量（而不是外部加热和冷却）的热控制方法，以便在高温制造过程中快速控制。这是通过反应堆设计专家团队内的跨学科相互作用，纳米颗粒合成，comsol建模以及成核和生长理论来实现的。该项目在理解和控制持续可扩展的纳米制造技术方面的知识提高了知识。该奖项反映了NSF的法定使命，并使用基金会的知识分子优点和更广泛的影响评估标准，被认为值得通过评估。