MRI: Acquisition of a high resolution Accela-LTQ FT Ultra mass spectrometer system

MRI：购置高分辨率 Accela-LTQ FT Ultra 质谱仪系统

• 批准号: 0923005
• 负责人: Basil Nikolau
• 金额: $ 82.15万
• 依托单位: Iowa State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-15 至 2012-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0923005&HistoricalAwards=false
• 关键词: MRI; Acquisition; resolution; Accela; LTQ

This Major Research Instrumentation (MRI) award funds the acquisition of a Bruker-Daltonics SolariXHybrid FTMS Bundle mass spectrometer system at the Iowa State University WM Keck Metabolomics Research Laboratory, and empowers multidisciplinary research from a wide sweep of departments that integrate disciplines of chemistry and biochemistry, biological sciences and engineering. The new instrument system will provide researchers with unprecedented data concerning biological molecules and thus enhance the research infrastructure of the University and the State. The projects supported by the new instrument system attempt to meet the challenge of deciphering functional understanding of genome expression at the metabolic level, and are a mixture of hypothesis-driven research on the structure and regulation of specific metabolic and gene networks, and high-throughput global profiling projects that seek to generate hypotheses concerning gene functionalities. The impact of these research projects will be greatly enhanced the SolariXHybrid FTMS Bundle mass spectrometer system because researchers will be able to more rigorously determine the chemical identities of metabolites and hence generate and test more robust hypotheses concerning the metabolic functionalities of gene products and gene networks.In addition, this instrument will provide faculty a vehicle for the multi-disciplinary research-based training of students, who will gain insights into how to conduct modern metabolic studies, integrating advances in chemistry and genomics biology. Post-docs, graduate students, undergraduate students from Iowa State University and neighboring colleges, and high-school students and teachers from the State of Iowa will also participate in research. These latter outreach activities will be coordinated through summer workshops, internship programs and NSF-REU programs that are already in place through the Centers (e.g., CBiRC) and projects (e.g., The Arabidopsis 2010 Metabolomics Consortium Project) that will utilize the instrument. Therefore students will be broadly mentored and trained to meet the emerging technological challenges of the 21st century. Results from the research projects will be disseminated through student and faculty presentations at regional or national meetings, and through publications in the peer-reviewed literature.

这项主要的研究工具（MRI）奖为爱荷华州立大学WM Keck代谢组学研究实验室的Bruker-Daltonics Solarixhybrid FTMS捆绑质量分类器系统的获取提供了资金，生物科学和工程。新的仪器系统将为研究人员提供有关生物分子的前所未有的数据，从而增强了大学和国家的研究基础设施。新仪器系统支持的项目试图应对在代谢水平上对基因组表达的解密功能理解的挑战，并且是对特定代谢和基因网络结构和调节的假设驱动研究的混合物，以及高通量旨在产生有关基因功能的假设的全球分析项目。这些研究项目的影响将大大增强Solarixhybrid FTMS束质谱仪系统，因为研究人员将能够更严格地确定代谢产物的化学身份，因此产生和测试了有关基因产物和基因网络的代谢功能的更强大假设。此外，该工具将为教师提供基于多学科研究的学生的培训，他们将获得有关如何进行现代代谢研究的见解，从而整合化学和基因组生物学方面的进步。爱荷华州立大学和邻近学院的研究生，研究生，本科生以及来自爱荷华州的高中生和老师也将参加研究。这些后者的宣传活动将通过夏季研讨会，实习计划和NSF-REU计划进行协调，这些计划已经通过中心（例如CBIRC）和项目（例如，拟南芥2010年代谢组合项目）进行了协调。因此，将对学生进行广泛的指导和培训，以应对21世纪的新兴技术挑战。研究项目的结果将通过区域或国家会议上的学生和教职员工演讲以及通过同行评审文献的出版物进行传播。