I-Corps: Novel Bio-Based Chemical Feedstocks for the Polymer Industry

I-Corps：用于聚合物行业的新型生物基化学原料

• 批准号: 1237247
• 负责人: Basil Nikolau
• 金额: $ 5万
• 依托单位: Iowa State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-15 至 2014-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1237247&HistoricalAwards=false
• 关键词: Corps; Novel; Bio; Based; Chemical

This Innovation Corps project will explore the potential of developing a marketable innovation based on the use of 3-ketoacyl ACP synthase III (KASIII) enzymes. KASIII catalyzes the first carbon-carbon forming reaction in fatty acid biosynthesis, and thus determines the chemical nature of the omega of the fatty acids produced. The proposed innovation is based on engineering of of the biocatalyst, KASIII, and would result in the production of bi-functional molecules that can act as the monomer percusors for making bio-based plastics. This innovation will provide novel bi-functional, bio-based feed stocks to the emerging bio-renewable chemical industry for the production of novel "green" plastics and specialty chemicals. The proposed I-Corps team envisions a technology that will be initially targeted to the synthesis of hydroxy-fatty acids, but can be readily advanced upon to produce other bi-functional monomers (e.g., amino-fatty acids, which can be used to produce polyamides). If successful, this technology will lead to chemical products that can act as substitutes for petroleum-based chemical products, and be precursors for novel bio-based products.

该创新军团项目将探索基于3-酮酰亚西尔ACP合酶III（KASIII）酶开发可销售创新的潜力。 Kasiii催化脂肪酸生物合成中的第一个碳碳形成反应，从而确定产生的脂肪酸的欧米茄的化学性质。拟议的创新基于生物催化剂，Kasiii的工程，并将导致生产双功能分子，这些分子可以充当制造基于生物的塑料的单体percusor。这项创新将为新兴的生物可再生化学工业提供新颖的生物功能基于生物的饲料库存，以生产新型的“绿色”塑料和特种化学品。拟议的I-Corps团队设想了一项技术，该技术最初是针对羟基脂肪酸的合成的，但很容易推进以生产其他双功能单体（例如，可以用于生产的氨基脂肪酸，可用于生产聚酰胺）。如果成功，该技术将导致可以用作石油基化学产品的化学产品，并成为新型生物基产品的前体。