MRI: Track 1 Acquisition of a High-Resolution Quadrupole Time-of-Flight Mass Spectrometer with Diverse Inlet and Ionization Capabilities for Chemical Analyses

MRI：轨道 1 采购具有多种入口和电离功能的高分辨率四极杆飞行时间质谱仪，用于化学分析

• 批准号: 2319939
• 负责人: Amanda Patrick
• 金额: $ 54.07万
• 依托单位: Mississippi State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2319939&HistoricalAwards=false
• 关键词: MRI; Track; Acquisition; Resolution; Quadrupole; MRI; Track; Acquisition; Resolution; Quadrupole

This award is jointly funded by the Major Research Instrumentation Program, the Chemistry Research Instrumentation Program, and the Established Program to Stimulate Competitive Research (EPSCoR). It supports the acquisition of instrumentation for ultra-performance liquid chromatography coupled with high-resolution quadrupole time-of-flight mass spectrometry (UPLC-qToF) by Mississippi State University, strengthening the research instrumentation infrastructure in Mississippi. High-resolution mass spectrometry is a critical instrumental technique for the characterization of new synthetic chemical species and is a sensitive method for detecting and characterizing low-concentration species, for example in biological and environmental samples. Twelve research groups in the Department of Chemistry are identified as users and the instrument will also be available to other researchers from across campus and beyond. In addition to supporting research activities, the instrument will also be used for educational activities, including training of student researchers and incorporation into laboratory courses. The new instrument will ensure that researchers at Mississippi State University continue to have access to state-of-the-art high-resolution mass spectrometry required for the characterization of novel syntheses and reaction monitoring. Several projects will make use of this aspect of the instrument, with examples including characterization of heterobimetallic complexes for hydrodenitrogenation processes relevant to production of cleaner fuels, characterization of catalysts and reaction products aimed at performing organic transformations in sustainable solvents like water or ethanol, and characterization of catalysts and reactions aimed at improving stereo- and site-selective functionalizations and transformations relevant to pharmaceutical manufacture among other applications. The new instrument has excellent sensitivity and is coupled to an ultra-high performance chromatography instrument, allowing for analyte species to be measured in low-concentration and/or complex matrix samples. Examples of research that will benefit from these aspects of the instrument include characterization of the adsorption and decomposition of polyfluoroalkyl substances (PFAS) with modified biochar and the characterization of ionic liquid degradation products that may be relevant as emerging environmental contaminants.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要的研究工具计划，化学研究工具计划和启发竞争性研究（EPSCOR）的既定计划共同资助。它支持密西西比州立大学的高分辨率四极杆质谱（UPLC-QTOF）的高分辨率四极杆质谱（UPLC-QTOF）的仪器的获取，从而加强了密西西比州密西西比州的研究仪器基础设施。高分辨率质谱是一种对新合成化学物种表征的关键仪器技术，是一种检测和表征低浓缩物种的敏感方法，例如在生物和环境样品中。化学系的十二个研究小组被确定为用户，该工具也将向各个校园及其他地区的其他研究人员提供。除了支持研究活动外，该工具还将用于教育活动，包括对学生研究人员的培训和纳入实验室课程。新工具将确保密西西比州立大学的研究人员继续访问新合成和反应监测所需的最先进的高分辨率质谱法。几个项目将利用仪器的这一方面，其中包括与与清洁燃料的生产，催化剂的特征和旨在在可持续溶剂中执行有机转化相关的有机转化的杂质金属复合物的表征药品制造和其他应用。新仪器具有出色的灵敏度，并与超高的性能色谱仪耦合，从而可以在低浓度和/或复杂矩阵样品中测量分析物。将从该仪器的这些方面受益的研究示例包括表征和分解多氟烷基物质（PFAS）具有修改的生物炭的表征以及离子液体降解产品的表征，这些产品可能与NSF的智力及其范围的启发性有关，这可能与新兴的环境范围相关。 标准。