MRI: Track 1: Acquisition of an Inductively Coupled Plasma Mass Spectrometer to Quantify Trace Metal Ions Enabling New Research and Research Training at Barnard College

MRI：轨道 1：购买电感耦合等离子体质谱仪来量化痕量金属离子，从而在巴纳德学院实现新的研究和研究培训

• 批准号: 2320054
• 负责人: Rachel Austin
• 金额: $ 23.8万
• 依托单位: Barnard College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2320054&HistoricalAwards=false
• 关键词: MRI; Track; Acquisition; Inductively; Coupled

This award is supported by the Major Research Instrumentation Program and the Chemistry Research Instrumentation Program. Drs. Austin, Brenner, Donegan, Mailloux, and Vizcarra at Barnard College will acquire an inductively coupled plasma mass spectrometer (ICP-MS). ICP-MS enables the measurement of very low levels of metals in many different sample types, including: biological molecules, tissues, solid materials (after appropriate treatment), and water samples. This instrument will allow researchers at Barnard and other institutions in the region to pursue important areas of research in the fields of Chemistry, Biology, and Environmental Science, including: groundwater and soil contamination; nutrient sources that fuel persistent, difficult-to-treat bacterial infections; and the global cycling of carbon. The acquisition of an ICP-MS at Barnard College will support students in a range of research and research training programs, including programs targeting at diversifying the scientific and engineering workforce. The acquisition of an ICP-MS will enable a number of different research groups to answer vexing questions about the role of metal ions in complex systems. The instrument will enable the determination of the cellular processes involved in heme uptake in non-tuberculosis mycobacterium. It will also facilitate identification of the active site of the non heme diiron enzyme alkane monooxygenase (AlkB). Questions about the coupling between the metabolism of anaerobic bacteria and arsenic solubilization will be addressed by using the ICP-MS to measure arsenic levels in water samples from mesocosm experiments. The capacity of oysters living in close proximity to an EPA-designated Superfund site to record lead contamination by analysis of their shells will be investigated using the instrument. The instrument will also contribute to on-going work to test the hypothesis that arsenic levels in rice grains are controlled, to a large extent, by zinc levels in soils, with high arsenic levels correlated with zinc-depleted soils. The ability of the instrument to detect trace levels of large number of metals will be used in several catalytic projects where the reaction medium will be examined to determine if metal ions are leaching from catalyst surfaces during chemical reactions.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项得到了主要的研究工具计划和化学研究工具计划的支持。博士。 Barnard College的Austin，Brenner，Donegan，Mailloux和Vizcarra将获得电感耦合等离子体质谱仪（ICP-MS）。 ICP-MS可以测量许多不同样本类型中的非常低水平的金属，包括：生物分子，组织，固体材料（经过适当的治疗）和水样品。该工具将允许Barnard和该地区其他机构的研究人员在化学，生物学和环境科学领域追求重要的研究领域，包括：地下水和土壤污染；燃料持续，难以治疗的细菌感染的营养来源；以及全球碳循环。 在巴纳德学院（Barnard College）收购ICP-MS将为学生提供一系列研究和研究培训计划的学生，包括针对多元化科学和工程劳动力的计划。 ICP-MS的获取将使许多不同的研究小组能够回答有关金属离子在复杂系统中的作用的烦恼问题。 该仪器将能够确定非连结核分枝杆菌中血红素摄取涉及的细胞过程。它还将促进鉴定非血红素二烷基单加氧酶（ALKB）的活性位点。 关于厌氧菌细菌的代谢与砷溶解化之间的耦合的问题将通过使用ICP-MS来测量中库群岛实验的水样中的砷水平来解决。使用该仪器对EPA指定的超级基金站点非常靠近的牡蛎的能力记录铅污染的能力将使用该仪器进行研究。 该仪器还将有助于持续的工作，以检验以下假设：稻粒中的砷水平在很大程度上受土壤中的锌水平控制，高砷水平与锌贫血的土壤相关。 该仪器检测痕量水平的大量金属的能力将用于几个催化项目，在这些项目中将检查反应培养基，以确定化学反应期间金属离子是否从催化剂表面浸出。该奖项反映了NSF的法定任务，并通过使用该基金会的知识分子优点和广泛的影响来评估NSF的法定任务，并被视为值得进行的支持。