MRI: Track 1 Acquisition of a Matrix-Assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometer for Analysis of Macromolecules

MRI：轨道 1 获取用于分析大分子的基质辅助激光解吸/电离飞行时间质谱仪

• 批准号: 2320090
• 负责人: Genevieve Sauve
• 金额: $ 31万
• 依托单位: Case Western Reserve University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2320090&HistoricalAwards=false
• 关键词: MRI; Track; Acquisition; Matrix; Assisted

This award is funded by the Major Research Instrumentation Program and the Chemistry Research Instrumentation Program. Professor Geneviève Sauvé from Case Western Reserve University, on behalf of 15 investigators from 8 departments across the university, is acquiring a matrix-assisted laser desorption/ionization time-of-flight mass spectrometer (MALDI-TOF MS). This instrument will enable a wide range of innovative and transformative research activities that depend upon a soft ionization mass spectroscopic technique with a large mass range, including analysis of fragile macromolecules, complex biomaterials and synthetic polymers. This instrument will strengthen the research infrastructure at the university and surrounding areas. It will improve recruitment and retention of the best students and faculty members. The instrument broadens participation by enabling new projects for a diverse student population, including economically disadvantaged high-school students from the Cleveland area. It will also advance education and training of diverse students at all levels and postdoctoral fellows.This award empowers innovative and transformative research activities across a wide variety of disciplines impacting fundamental STEM areas ranging from materials-energy research to the study of problems at the chemical biology interface. The detailed characterization of macromolecules provided by the new instrument are difficult to achieve by other techniques or equipment available to CWRU scholars. The instrument will lead to the development of new knowledge in areas including: pi-conjugated materials, nonlinear optical materials, fluorescent polymer brushes, graphynes, bioinspired nanomaterials, imaging and contrasting agents, functionalized gas-core nanoparticles, biomolecules with targeted surface-adhesive properties, tissue engineered products, DNA nanostructures, regulation of cellular processes, understanding chemical damage of RNA/DNA by sensitizers, and elucidating molecular mechanisms of the estrogen receptor alpha protein. This knowledge will enable and accelerate research that will benefit society, with practical applications including: printed optoelectronic devices such as photovoltaics and light emitting diodes, artificial blood surrogates to address shortages for blood transfusion, ways to protect RNA/DNA from photodamage, stable DNA nanostructures with programmable therapeutic properties, new brush copolymers to revolutionize cataract surgery, novel molecules that will revolutionize detection and treatment of cancer, enhanced MRI contrast agents, and improved engineered cartilage quality.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要的研究工具计划和化学研究工具计划资助。凯斯西部储备大学的GenevièveSauvé教授代表来自该大学的8个部门的15个调查人员正在收购矩阵辅助激光解吸/电离飞行时间质谱仪（MALDI-TOF MS）。该仪器将实现广泛的创新和变革性研究活动，这些研究活动取决于具有较大质量范围的软电离质谱技术，包括分析脆弱的大分子，复杂的生物材料和合成聚合物。该工具将加强大学及周边地区的研究基础设施。它将改善最好的学生和教职员工的招聘和保留。该工具通过为潜水员的学生群体（包括来自克利夫兰地区的经济不利的高中生）启用新项目来扩大参与。它还将在各个层面和博士后研究员的教育和培训中进行教育和培训。该奖项促进了各种学科的创新和变革性研究活动，这些学科影响了从材料能量研究到化学生物学界面问题的基本茎领域的各种学科。新仪器提供的大分子的详细表征很难通过CWRU学者可用的其他技术或设备来实现。该仪器将导致在包括：PI结合材料，非线性光学材料，荧光聚合物刷子，图形，生物启动的纳米材料，成像和对比剂，功能化的气核纳米颗粒，具有靶向表面上的化学物质的生物分子，dna nnan nnan nnan NNAN NNANAN NNAN NNAN NAN NAN NANAN NNAN NAN NANAN NNAN NNAN NANNAN NANANOPRECTES，D.传感器的RNA/DNA，并阐明雌激素受体α蛋白的分子机制。这些知识将实现和加速研究，将有益于社会，包括：印刷的光电设备，例如光伏和发射光二极管，人造血液替代物来解决血液输血的短缺，可保护RNA/DNA的方法，以保护RNA/DNA免受光dna危险，稳定的DNA纳米结构，可在稳定的DNA纳米结构，以确定新的nan nanystripe oparecor copyries copormul copormul copormul coprime copormul copartip of rotakem coprime copormul coprolies copormul coprolies copormul，这将彻底改变对癌症的检测和治疗，增强了MRI对比剂并提高了工程软骨质量。该奖项反映了NSF的法定任务，并使用基金会的知识分子优点和更广泛的影响审查标准，被视为通过评估来获得珍贵的支持。