MRI: Track 3 Acquisition of a Helium Liquefaction and Recovery System for METRIC NMR Laboratories at NC State

MRI：轨道 3 为北卡罗来纳州 METRIC NMR 实验室采购氦液化和回收系统

• 批准号: 2320092
• 负责人: Xiaoyan Sun
• 金额: $ 43.4万
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2320092&HistoricalAwards=false
• 关键词: MRI; Track; Acquisition; Helium; Liquefaction

This award is jointly supported by the Major Research Instrumentation (MRI), and the Chemistry Research Instrumentation (CRIF) programs in response to the solicitation of proposals that promote the recovery, recycle, and/or reuse of helium. North Carolina State University is acquiring a helium recovery system to capture and reliquefy helium from eight NMR spectrometers which support the research of Xiaoyan Sun along with colleagues Peter Thompson, and Joseph Barycki. This equipment supports research in the areas of chemistry, biology, biochemistry, and materials science. Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. Using the intrinsic magnetic properties of atomic nuclei, it is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The superconducting magnets of these instruments rely on regular deliveries of liquid helium to maintain their operation. However, the instability in the helium supply due to global and national challenges jeopardizes research programs relying on NMR spectroscopy. This helium recovery system collects the helium boiloff from the superconducting magnets and then reliquefies the helium for its reuse. This equipment also supports the educational, research, and teaching efforts of students, including undergraduates from groups underrepresented in STEM, at all levels in multiple departments and the surrounding community. The equipment aids in stabilizing the helium supply in the region by sharing recovered helium with neighboring institutions.This award is aimed at supporting research and education at all levels. Specifically, this helium recovery system collects the helium boiloff for reliquefication and reuse from the superconducting magnets thereby stabilizing the operation of the institution’s eight NMR spectrometers. The NMR instrumentation supported by this equipment enables research projects including those focused on studying the effects of coherent electronic motions occurring in energy and electron transfer in classes of multi-chromophoric synthetic platforms. The recovery system aids in supporting the investigation of temperature and concentration dependent characteristics of pre-crystallizing solutions. Additionally, the acquisition of this equipment supports the characterization of free base and iron chelates and designer paramagnetic ligands in donor-bridge-acceptor biradical complexes. Other research projects supported by this equipment include the synthesis and use of N-aryl peptides as novel precursors for peptide ligation reactions and the ability to probe the changes in dehaloperoxidase dynamics as a function of substrate binding and type.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要的研究工具（MRI）共同支持，而化学研究仪器（CRIF）计划响应促进培训，回收和/或再利用氦气的提案。北卡罗来纳州立大学正在从八个NMR光谱仪中捕获和重新捕获氦气恢复系统，这些NMR光谱仪与彼得·汤普森（Peter Thompson）和约瑟夫·巴里奇（Joseph Barycki）一起支持肖亚·太阳的研究。该设备支持化学，生物学，生物化学和材料科学领域的研究。核磁共振（NMR）光谱是化学家可用于阐明分子结构的最强大工具之一。使用原子核的固有磁特性，它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间或固态中分子之间相互作用的动力学。对于正在进行边境研究的化学家来说，获得最先进的NMR光谱仪至关重要。这些仪器的超导磁铁依赖于定期输送液态氦气以保持其运行。然而，由于全球和国家挑战引起的氦气供应的不稳定危害了依赖NMR光谱的研究计划。该氦回收系统从超导磁铁中收集氦气沸腾，然后重新使用氦气以重复使用。该设备还支持学生的教育，研究和教学工作，包括在STEM中代表性不足的团体的基础，在多个部门和周围社区的各个层面。该设备通过与邻近机构共享回收的氦气来帮助稳定该地区的氦气供应。该奖项旨在在各个层面上支持研究和教育。特别是，该氦恢复系统收集了氦气沸腾，以重新使用Releiquefication，并从超导磁铁中重新使用，从而稳定了该机构的八个NMR光学图案。该设备支持的NMR仪器能够进行研究项目，包括专注于研究在能量和电子传输中，在多种鸡蛋性合成平台类别中发生的相干电子运动的影响。恢复系统有助于支持温度和浓度依赖性解决方案的投资。此外，该设备的采集还支持供体桥 - 受体 - 感受器Biradical Complexs中自由碱和铁化学配体的表征。该设备支持的其他研究项目包括合成和使用N- Aryl Pepperides作为肽连接反应的新型前体，以及探测去氧化氧化酶动力学的变化的能力，作为基质结合和类型的函数。该奖项反映了NSF的法定任务，并通过评估了基金会的MERITIAL和BRIDIT and IFTIAL和BRIDIT and IFTIAL和BRIDIT and IFTIAL和BRODITIAL和BRODITIAL和BRODITIAL和BRODITIAL和BRODITIAL和BRODITIAL。