ShEEP Request for Bruker BioSpec 3T MRI System Upgrade

ShEEP 请求布鲁克 BioSpec 3T MRI 系统升级

• 批准号: 10740786
• 负责人: Eric Y Chang
• 金额: --
• 依托单位: VA SAN DIEGO HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-01 至 2023-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10740786
• 关键词: Acceleration; Amplifiers; Anatomy; Animals; Beds; Behavioral Research; Biomedical Engineering; Cardiac; Cardiology; Caregivers; Caring; Clinic; Communities; Complex; Core Facility; Degenerative polyarthritis; Detection; Disease; Endocrinology; Floor; Foundations; Functional Magnetic Resonance Imaging; Funding; Future; Gastroenterology; Healthcare; Healthcare Systems; Image; Imaging Techniques; Injury; Magnetic Resonance Imaging; Malignant Neoplasms; Measurement; Medical Research; Medical center; Mission; Modality; Morphology; Mus; Muscle function; Nerve Degeneration; Neurology; Noise; Oncology; Operative Surgical Procedures; Organ; Orthopedics; Patients; Performance; Phase; Pre-Clinical Model; Productivity; Protons; Psychiatry; Pulmonology; Radiology Specialty; Renal function; Research; Research Personnel; Resolution; Rodent; Sampling; Scanning; Services; Sheep; Signal Transduction; Sodium; Stroke; System; Time; Translational Research; United States Department of Veterans Affairs; Veterans; Water; bench-to-bedside translation; blood oxygen level dependent; brain magnetic resonance imaging; clinical care; cost; cryogenics; data acquisition; experimental study; field study; imaging capabilities; imaging system; improved; in vivo; neuroimaging; neuroinflammation; nuclear imaging; pre-clinical; pre-clinical research; radio frequency

The capability of performing longitudinal magnetic resonance imaging (MRI) on small animals in vivo significantly and positively impacts a large number of VA-supported projects in basic, translational and preclinical biomedical/behavioral research relevant to Veteran's healthcare currently conducted at the Jennifer Moreno VA Medical Center (JMVAMC) (formerly known as the VA San Diego Healthcare System). We have a Bruker BioSpec 3T small animal MRI system which is integrated into the centralized JMVAMC/Veterans Medical Research Foundation Microimaging Core facility, but the current configuration is limited in its ability to perform rapid scans, including the inability to perform high-quality mouse cardiac and mouse functional brain MRI experiments. We are a group of 18 investigators with active VA funding who will directly benefit from upgrading the existing Bruker BioSpec 3T MRI system. Our projects which will benefit from the upgrades encompass a wide range of fields and research, including radiology, cardiology, orthopaedics, bioengineering, neurology, psychiatry, pulmonology, endocrinology, gastroenterology, oncology, and surgery. Upgrading our small animal MRI imaging system to the latest state-of-the-art system will not only impact basic pre-clinical research at JMVAMC, but is also expected to have a strong and positive effect through improvement of patient clinical care. The imaging techniques employed on our 3T system are readily incorporated to the clinic, ultimately supporting the VA healthcare mission.

对小动物活体进行纵向磁共振成像（MRI）的能力显着提高 并对 VA 支持的大量基础、转化和临床前项目产生积极影响 目前在詹妮弗·莫雷诺进行的与退伍军人医疗保健相关的生物医学/行为研究 退伍军人管理局医疗中心 (JMVAMC)（以前称为退伍军人管理局圣地亚哥医疗系统）。我们有布鲁克 BioSpec 3T 小动物 MRI 系统集成到集中式 JMVAMC/Veterans Medical 中 研究基金会微成像核心设施，但当前配置的执行能力有限 快速扫描，包括无法进行高质量的小鼠心脏和小鼠功能性大脑 MRI 实验。我们是一个由 18 名研究人员组成的小组，拥有 VA 的积极资助，他们将直接从升级中受益 现有的 Bruker BioSpec 3T MRI 系统。我们将从升级中受益的项目包括 广泛的领域和研究，包括放射学、心脏病学、骨科、生物工程、神经病学、 精神病学、肺病学、内分泌学、胃肠病学、肿瘤学和外科。升级我们的小动物 MRI 成像系统到最新最先进的系统不仅会影响基础临床前研究 JMVAMC，但也有望通过改善患者临床护理产生强大而积极的影响。 我们的 3T 系统上采用的成像技术很容易融入临床，最终支持 退伍军人管理局的医疗保健使命。