Ultra-low distortion and noise electronics to enable a clinical MPI imaging platform

超低失真和噪声电子器件支持临床 MPI 成像平台

• 批准号: 10761613
• 负责人: Patrick Goodwill
• 金额: $ 100.85万
• 依托单位: MAGNETIC INSIGHT, INC.
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-22 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10761613
• 关键词: Air; Amplifiers; Anatomy; Animals; Applications Grants; Area; Brain; Categories; Cell Therapy; Cells; Classification; Climacteric; Clinical; Clinical Treatment; Complex; Coupling; Development; Diagnosis; Discipline of Nuclear Medicine; Disease; Electric Capacitance; Electronics; Engineering; Floor; Functional Imaging; Goals; Grant; Half-Life; Hemorrhage; Hemosiderin; Human; Image; Imaging Techniques; Imaging technology; Inflammation; Infrastructure; Institution; International; Magnetic Resonance Imaging; Magnetic nanoparticles; Magnetism; Marketing; Measurement; Measures; Medical Imaging; Medicine; Modality; Modernization; Molecular; Monitor; Noise; Pathology; Performance; Phase; Physics; Physiologic pulse; Physiological; Positron-Emission Tomography; Pre-Clinical Model; Radioactive; Radioactive Tracers; Resolution; Roentgen Rays; Role; Safety; Scientist; Shipping; Signal Transduction; Small Business Innovation Research Grant; Speed; Structure; System; Techniques; Technology; Testing; Tissues; Tracer; Visualization; Work; cellular imaging; clinical diagnosis; clinical imaging; commercialization; contrast imaging; design; human imaging; imager; imaging modality; imaging platform; imaging system; improved; innovation; insight; instrument; magnetic field; nano; new technology; nuclear imaging; particle; pre-clinical; prototype; research clinical testing; single photon emission computed tomography; stem cells; tool; transmission process; ultrasound; voltage

SUMMARY/ABSTRACT In this SBIR grant proposal, “Ultra-low distortion and noise electronics to enable a clinical MPI imaging platform,” we will develop the RF subsystem for a clinical magnetic particle imaging (MPI) platform to enable three classes of MPI applications: cell tracking, functional imaging, and endogenous contrast imaging. Our overall approach is to improve sensitivity and resolution by minimizing distortion, adding transmit/receive channels, decoupling, improving preamplifiers, and developing new pulse sequences. MPI is an emerging molecular and tracer imaging technology that directly detects magnetic nanoparticles (MNPs) with high sensitivity at mm-scale resolutions. MPI images are direct views of tracer distribution with no signal arising from tissue, no perturbations from materials such as air, and image intensity directly linear with tracer concentration. This “hot-spot” contrast provides spatial localization and quantification without ambiguity. MPI’s contrast is similar to nuclear medicine but without the workflow, safety, and half-life limitations of a radioactive tracer. MPI has many applications in the brain and body, as demonstrated by our customers in small animals. Despite significant efforts by multiple institutions, the lack of a clinical MPI scanner remains a significant limitation for the technique. In this Direct to Phase II SBIR proposal, we will advance the medical imaging field by building the world’s first general-purpose clinical MPI scanner to serve the myriad applications our customers are testing on our preclinical instrument. We will design and implement a new transmit/receive subsystem and install it in our prototype scanner to achieve the performance necessary for clinical imaging applications. This new transmit/receive subsystem includes the following innovations that push our sensitivity from our current rough prototype to near the physics limit through the following specific aims: Aim 1. Drive transmit distortion and the noise floor to the physics limit for a one-channel Tx/Rx coil Aim 2. Design a clinical multi-channel transmit and receive subsystem Aim 3. Develop new acquisition pulse sequences to improve sensitivity, resolution, and speed

摘要/摘要 在这个SBIR赠款提案中，“超低失真和噪声电子可以使临床MPI成像平台”，” 我们将开发用于临床磁性粒子成像（MPI）平台的RF子系统，以启用三类 MPI应用：细胞跟踪，功能成像和内源性对比成像。我们的整体方法是 通过最大程度地减少失真，添加传输/接收通道，去耦， 改善前置放大剂，并开发新的脉冲序列。 MPI是一种新兴的分子和示踪剂成像技术，可直接检测磁性纳米颗粒 （MNP）在MM级分辨率方面具有高灵敏度。 MPI图像是示踪剂分布的直接视图，没有 由组织产生的信号，没有材料（例如空气）的扰动，以及直接与图像强度直接与 示踪剂浓度。这种“热点”对比度提供了空间定位和数量，而没有歧义。 MPI的对比类似于核医学，但没有工作流程，安全性和半衰期的限制 放射性示踪剂。 MPI在大脑和身体中有许多应用，我们的客户在小规模 动物。尽管多个机构付出了巨大的努力，但缺乏临床MPI扫描仪仍然很重要 该技术的限制。 在直接达到II阶段SBIR提案中，我们将通过建立世界 第一个通用临床MPI扫描仪为我们的客户测试我们的众多应用程序 临床前仪器。我们将设计和实施一个新的发送/接收子系统，并将其安装在我们的 原型扫描仪以实现临床成像应用所需的性能。这个新 传输/接收子系统包括以下创新，这些创新使我们的敏感性从目前的粗糙 通过以下特定目的，原型到附近的物理限制： AIM 1。驱动单通道TX/RX线圈的噪声驱动器和噪声层到物理极限 目标2。设计临床多通道传输和接收子系统 目标3。开发新的采集脉冲序列以提高灵敏度，分辨率和速度