Dissertation Research: Menstrual Variation in Salivary Testosterone

论文研究：唾液睾酮的月经变化

• 批准号: 8821699
• 负责人: Peter Ellison
• 金额: $ 0.52万
• 依托单位: Harvard University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-02-01 至 1990-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8821699&HistoricalAwards=false
• 关键词: Dissertation; Research; Menstrual; Variation; Salivary

Testosterone is one of the three major female steroid hormones (along with estrogen and progesteron). Testosterone is important in female reproductive function for its effects on both folliculogenesis and sexual behavior. Yet, despite demonstratations that testosterone levels change under a number of differenct ecological conditions, testosterone has not received much attention in studies of reproductive ecology. Assays of salivary testosterone offer several advantages, including non-invasive collections techniques and a measure of the non-bound fraction of the hormone levels is an appropriate means for analyzing ovarian function. Daily salivary samples will be collected for a single menstrual cycle from Boston women between the ages of 20 and 40. All samples will be assayed for testosterone, and for estradial which will be used to align the cycles. The results of the research will further our understanding of gonadal function in women. The data will not only demonstrate the use of salivary assays of testosterone as an indictor of ovarian function, but may have implications for changes in sexual behavior, such as coital frequency. This will be the first step towards incorporating the measurement of salivary testosterone into field studies of reproductive behavior and ecology.

睾酮是三大女性类固醇激素之一（另外两个是雌激素和黄体酮）。 睾酮对女性生殖功能很重要，因为它对卵泡发生和性行为都有影响。 然而，尽管有证据表明睾酮水平在许多不同的生态条件下会发生变化，但睾酮在生殖生态学研究中并未受到太多关注。 唾液睾酮测定具有多种优点，包括非侵入性采集技术，并且测量激素水平的非结合部分是分析卵巢功能的适当方法。 将从 20 岁至 40 岁之间的波士顿女性的一个月经周期中采集每日唾液样本。所有样本都将进行睾酮和雌激素检测，用于调整周期。 研究结果将进一步加深我们对女性性腺功能的了解。 这些数据不仅证明唾液睾酮检测可以作为卵巢功能的指标，而且可能对性行为的变化（例如性交频率）产生影响。 这将是将唾液睾酮测量纳入生殖行为和生态学实地研究的第一步。