Cyclical deficits in emotion regulation as a risk factor for alcohol misuse in premenopausal females

情绪调节的周期性缺陷是绝经前女性酗酒的危险因素

• 批准号: 10581399
• 负责人: Raina Pang
• 金额: $ 54.46万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10581399
• 关键词: Address; Alcohol consumption; Alcohols; Awareness; Behavior; Behavioral Symptoms; DSM-V; Data; Development; Dimensions; Distress; Ecological momentary assessment; Emotional; Emotions; Etiology; Female; Gonadal Steroid Hormones; Health; Heart Rate; Heavy Drinking; Impairment; Individual; Individual Differences; Literature; Longevity; Luteal Phase; Maps; Measures; Mediation; Menstrual cycle; Menstruation; Meta-Analysis; Mood Disorders; Motivation; National Institute on Alcohol Abuse and Alcoholism; Pathway interactions; Patient Self-Report; Periodicity; Peripheral; Persons; Physiological; Premenopause; Prevention strategy; Progesterone; Psychological reinforcement; Psychophysiology; Recurrence; Research; Risk; Risk Factors; Sampling; Severities; Skin Temperature; Source; Strategic Planning; Symptoms; Testing; United States National Institutes of Health; Women' s Health; alcohol consequences; alcohol craving; alcohol misuse; alcohol relapse; alcohol risk; clinically significant; coping; emotion regulation; emotional symptom; experience; gender difference; heart rate variability; high intensity drinking; indexing; individualized medicine; male; physical symptom; premenstrual dysphoric disorder; prospective; recruit; reproductive; response; risk sharing; screening; sensor; sex; theories; wearable sensor technology

PROJECT SUMMARY Alcohol misuse is rising in females. As females may experience worse health consequences then males and female-specific risks associated with alcohol misuse, elucidating female-specific factors is essential to build a better understanding of alcohol misuse in females and the development of prevention strategies for alcohol misuse in females. A small literature implicates dimensional premenstrual dysphoric disorder (dPMDD)—a mood disorder characterized by clinically significant emotional, behavioral, and physical symptoms during the late luteal that completely resolve by the mid follicular—as a critical female-specific risk factor for alcohol misuse and luteal phase increases in alcohol use. However, no studies to date have evaluated the shared physiological and emotional pathways of dPMDD and alcohol misuse. Emotion regulation encompasses the awareness and identification of emotion, and strategies to modify the emotional response. Emotion regulation may also be physiologically represented. Heart rate variability (HRV), an index of parasympathetic control over heartrate, is considered a peripheral psychophysiological marker of emotion regulation. Reduced subjective and objective (i.e., HRV) emotion regulation has been shown to associate with alcohol misuse. However, studies have not investigated how cyclical changes in emotion regulation may act as a risk factor for alcohol misuse and whether this differs between females with compared to without dPMDD. HRV shows the lowest levels during the luteal phase and our pilot data shows greater luteal phase reductions in HRV map onto more significant increases in luteal phase negative emotion. Our central hypothesis is that females with dPMDD suffer from recurrent luteal phase increases in heavy drinking due to progesterone-related declines in HRV and associated deficits in emotion regulation. The proposed study will recruit premenopausal females with heavy alcohol use (50% dPMDD) who will complete 4 weeks of prospective screening; and 5 weeks of Ecological Momentary Assessment (EMA) and HRV assessment. Aim 1 tests the hypothesis that dPMDD will show larger luteal phase increases in alcohol misuse relative to no dPMDD. Aim 2 tests the hypothesis that cyclical deficits in emotion regulation will predict cyclical increases in alcohol misuse. Aim 3 tests the hypothesis that individual differences in the degree of HRV reduction from the follicular to the luteal phase will predict greater luteal phase increases in alcohol variables. The results of this study will importantly contribute to the NIH strategic plan for research addressing sex/gender differences and female health. Specifically, this study will provide information on cyclical emotion regulation associations with alcohol misuse, which will provide foundational information regarding the influence of emotion regulation in the context of heavy drinking and the etiologic overlap between female alcohol misuse and emotion regulation in dPMDD.

项目概要 女性滥用酒精的情况正在增加，因为女性可能会比男性遭受更严重的健康后果。 女性特有的与滥用酒精相关的风险，阐明女性特有的因素对于建立一个 更好地了解女性酗酒和制定酒精预防策略 一小部分文献涉及女性经前焦虑症 (dPMDD)——一种 情绪障碍，其特征是在治疗期间出现临床上显着的情绪、行为和身体症状 黄体晚期在卵泡中期完全消退——这是女性特有的酒精关键危险因素 然而，迄今为止还没有研究评估过滥用和黄体期饮酒的共同点。 dPMDD 和酒精滥用的生理和情绪途径包括 情绪的意识和识别，以及调整情绪反应的策略。 心率变异性（HRV）也可以用生理学方式表示，心率变异性是副交感神经控制的指标。 心率被认为是情绪调节减少的外周心理生理标志。 客观（即 HRV）情绪调节已被证明与酗酒有关。 研究尚未调查情绪调节的周期性变化如何成为酒精的危险因素 误用以及有 dPMDD 的女性与没有 dPMDD 的女性之间是否存在差异显示出最低的 HRV。 黄体期期间的水平，我们的试验数据显示黄体期 HRV 的更大减少映射到更多 我们的中心假设是，患有 dPMDD 的女性黄体期负面情绪显着增加。 由于黄体酮相关的 HRV 下降，大量饮酒导致黄体期反复增加， 拟议的研究将招募患有重度抑郁症的绝经前女性。 饮酒（50% dPMDD）的人将完成 4 周的前瞻性筛查和 5 周的生态筛查； 瞬时评估 (EMA) 和 HRV 评估 目标 1 检验 dPMDD 将显示更大的假设。 与无 dPMDD 相比，黄体期酒精滥用增加 目标 2 检验了周期性缺陷的假设。 情绪调节能力将预测酒精滥用的周期性增加 目标 3 检验了个体的假设。 从卵泡期到黄体期 HRV 降低程度的差异将预测黄体期更大 这项研究的结果将对 NIH 的战略做出重要贡献。 具体而言，本研究将提供解决性别差异和女性健康问题的研究计划。 关于周期性情绪调节与滥用酒精之间的关联的信息，这将提供基础 有关酗酒情况下情绪调节的影响及其病因的信息 女性酒精滥用与 dPMDD 情绪调节之间的重叠。