Anxiety and Endocrine Function

焦虑与内分泌功能

• 批准号: 9514300
• 负责人: Peter Ellison
• 金额: $ 24.21万
• 依托单位: Harvard University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-03-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9514300&HistoricalAwards=false
• 关键词: Anxiety; Endocrine; Function

This project is designed to assess the association between two forms of psychosocial stress, chronic and acute anxiety, and human ovarian function as indexed by profiles of salivary progesterone and estradiol. Variation in each form of stress will be assessed at two levels, between women and within individual women. Chronic and acute anxiety will be assessed by standard psychological tests and by patterns of salivary cortisol. The project will be composed of two separate studies. In the first study, 120 subjects will be screened for levels of chronic anxiety. Twenty women at both the high and low end of the distribution will be asked to collect daily saliva samples for hormonal analysis and assessment of ovarian function. In the second study, 20 subjects subject to a common acute stressor (the Medical College Admissions Test), will be matched with subjects not subject to the stress. Salivary hormone levels and ovarian function will be assessed in both groups in the month of the test and again three moths later. This project incorporates several distinct advantages over previous research on the effects of psychosocial stress on reproductive physiology. It is prospective in design and double-blind in execution, eliminating ambiguities in the interpretation of dependent and independent variables. It incorporates sensitive measures of ovarian function which have been found to be responsive to other environmental and situational stresses. It involves two different explicit measures of the independent variables, one of which directly reflects physiological stress responses. It distinguishes the effects of chronic and acute anxiety, and variation between and within women. The results of this project will provide a much clearer assessment of the impact of anxiety on human ovarian function than has been possible previously, and should contribute to our understanding of broader issues in neuroendocrinology.

该项目旨在评估两种形式的社会心理压力（慢性和急性焦虑）与以唾液黄体酮和雌二醇特征为索引的人类卵巢功能之间的关联。每种压力形式的变化将在两个层面进行评估，即女性之间和女性个体内部。 慢性和急性焦虑将通过标准心理测试和唾液皮质醇模式进行评估。 该项目将由两项独立的研究组成。 在第一项研究中，将对 120 名受试者进行慢性焦虑水平筛查。 将要求分布高端和低端的 20 名女性每天收集唾液样本，用于激素分析和卵巢功能评估。 在第二项研究中，20 名遭受常见急性压力源（医学院入学考试）的受试者将与未遭受压力的受试者进行匹配。 将在测试当月以及三个月后再次评估两组的唾液激素水平和卵巢功能。 与之前关于心理社会压力对生殖生理学影响的研究相比，该项目具有几个明显的优势。它在设计上具有前瞻性，在执行上是双盲的，消除了因变量和自变量解释中的歧义。它结合了卵巢功能的敏感测量，已发现这些测量对其他环境和情境压力有反应。 它涉及自变量的两种不同的显式测量，其中之一直接反映生理应激反应。 它区分了慢性和急性焦虑的影响，以及女性之间和女性内部的差异。 该项目的结果将比以前更清晰地评估焦虑对人类卵巢功能的影响，并有助于我们理解神经内分泌学中更广泛的问题。