Anxiety and Endocrine Function

焦虑与内分泌功能

• 批准号: 9514300
• 负责人: Peter Ellison
• 金额: $ 24.21万
• 依托单位: Harvard University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-03-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9514300&HistoricalAwards=false
• 关键词: Anxiety; Endocrine; Function

This project is designed to assess the association between two forms of psychosocial stress, chronic and acute anxiety, and human ovarian function as indexed by profiles of salivary progesterone and estradiol. Variation in each form of stress will be assessed at two levels, between women and within individual women. Chronic and acute anxiety will be assessed by standard psychological tests and by patterns of salivary cortisol. The project will be composed of two separate studies. In the first study, 120 subjects will be screened for levels of chronic anxiety. Twenty women at both the high and low end of the distribution will be asked to collect daily saliva samples for hormonal analysis and assessment of ovarian function. In the second study, 20 subjects subject to a common acute stressor (the Medical College Admissions Test), will be matched with subjects not subject to the stress. Salivary hormone levels and ovarian function will be assessed in both groups in the month of the test and again three moths later. This project incorporates several distinct advantages over previous research on the effects of psychosocial stress on reproductive physiology. It is prospective in design and double-blind in execution, eliminating ambiguities in the interpretation of dependent and independent variables. It incorporates sensitive measures of ovarian function which have been found to be responsive to other environmental and situational stresses. It involves two different explicit measures of the independent variables, one of which directly reflects physiological stress responses. It distinguishes the effects of chronic and acute anxiety, and variation between and within women. The results of this project will provide a much clearer assessment of the impact of anxiety on human ovarian function than has been possible previously, and should contribute to our understanding of broader issues in neuroendocrinology.

该项目旨在评估两种形式的社会心理压力，慢性焦虑和急性焦虑以及人类卵巢功能之间的关联，如唾液孕酮和雌二醇的特征所索引。每种压力形式的差异将在妇女和单个女性内部的两个级别进行评估。 慢性和急性焦虑将通过标准心理测试和唾液皮质醇的模式来评估。 该项目将由两项单独的研究组成。 在第一项研究中，将筛选120名受试者的慢性焦虑水平。 将要求分布的高端和低端二十名妇女收集每日唾液样本，以进行荷尔蒙分析和评估卵巢功能。 在第二项研究中，将有20名受到常见急性压力源（医学院入学考试）的受试者与不受压力的受试者相匹配。 在测试月份，将在两组中评估唾液激素水平和卵巢功能，然后在三个飞蛾之后进行评估。 该项目比以前关于社会心理压力对生殖生理学的影响的研究融合了几个不同的优势。它在设计和双盲执行方面是预期的，从而消除了依赖和自变量的解释中的歧义。它结合了对卵巢功能的敏感度量，这些方法已被发现对其他环境和情境应力有反应。 它涉及两种不同的自变量的明确度量，其中一个直接反映了生理压力反应。 它区分了慢性和急性焦虑的影响以及女性之间和内部的变化。 该项目的结果将对焦虑对人类卵巢功能的影响提供比以前可能更清晰的评估，并应为我们对神经内分泌学方面的更广泛问题做出贡献。