Dissertation Research: Distinguishing Psychological from Energetic Stress Effects on Ovarian Function

论文研究：区分心理压力和能量压力对卵巢功能的影响

• 批准号: 0092076
• 负责人: Peter Ellison
• 金额: $ 0.5万
• 依托单位: Harvard University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-01 至 2003-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0092076&HistoricalAwards=false
• 关键词: Dissertation; Research; Distinguishing; Psychological; Energetic

The female reproductive system is sensitive to its environment, and ovarian function is often suppressed when confronted with a stressor. Suppression of reproductive function is generally proposed to be an adaptive response in that it channels resources towards vital functions while diminishing the likelihood of conception at a time when a successful reproductive outcome is marginal. But while such an effect is well documented for energetic stresses such as low dietary intake, high physical activity or both, the evidence in support of a direct effect of psychological stress on ovarian function is inconclusive. Although some studies have found a relationship between psychological stress and suppression of ovarian function, this interaction could be mediated by energetics, that is, by changes in activity or eating patterns that result from the psychological stress. This project is designed to determine if psychological stress influences ovarian function independent of energetic stress. The proposed project is designed to investigate 1) the relationships between psychological and energetic stress and 2) the individual and combined effects of psychological and energetic stresses on bio-markers of metabolism and ovarian function. Behavioral (food intake and physical activity), physiological (urinary c-peptide, salivary estradiol, progesterone, and cortisol), psychological (anxiety, depression and perceived stress) and anthropometric data will be collected and analyzed to investigate the relationships between psychosocial stressors, energetic stressors, metabolism and female reproductive physiology over the menstrual cycle.

女性生殖系统对其环境敏感，卵巢功能在面临压力时常常受到抑制。生殖功能的抑制通常被认为是一种适应性反应，因为它将资源引导至重要功能，同时在成功的生殖结果微乎其微时减少受孕的可能性。 但是，虽然这种效应对于能量压力（例如低饮食摄入量、高体力活动或两者兼而有之）有充分的记录，但支持心理压力对卵巢功能直接影响的证据尚无定论。 尽管一些研究发现心理压力与卵巢功能抑制之间存在关系，但这种相互作用可能是由能量学介导的，即心理压力导致的活动或饮食模式的变化。 该项目旨在确定心理压力是否会独立于能量压力影响卵巢功能。该项目旨在研究 1) 心理和能量压力之间的关系，以及 2) 心理和能量压力对代谢和卵巢功能生物标志物的个体和综合影响。 将收集和分析行为（食物摄入和体力活动）、生理（尿液 C 肽、唾液雌二醇、黄体酮和皮质醇）、心理（焦虑、抑郁和感知压力）和人体测量数据，以调查社会心理压力源之间的关系，月经周期中的能量压力源、新陈代谢和女性生殖生理学。