Development of a PET insert for hybrid PET/MR neuroimaging

开发用于混合 PET/MR 神经成像的 PET 插入物

• 批准号: 536762-2019
• 负责人: Goertzen, Andrew
• 金额: $ 7.74万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Idea to Innovation
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=692915
• 关键词: Development; PET; insert; hybrid; MR

The combination of positron emission tomography (PET) with magnetic resonance imaging (MRI) creates a powerful hybrid imaging modality due to the synergy of the sensitive molecular imaging capability of PET with the high quality anatomical, connective and functional imaging of MRI. This is particularly true for imaging of the brain, where the combination of the two modalities opens unique insights into understanding and quantifying changes in brain structure and function in neurodegenerative disease. Unfortunately, hybrid simultaneous PET/MRI is only available at a very small number of imaging centres due to the high capital costs of the currently available fully integrated PET/MRI systems. In addition, these systems are designed for whole-body oncology imaging applications, and thus are not ideal for brain imaging. We propose to develop a brain PET imaging system that can be retrofit to an existing MRI, creating the capability to perform simultaneous PET/MRI neuroimaging. As compared with existing whole body PET/MRI, the BrainPET insert will be low cost, while providing improved spatial resolution and detection efficiency due to the geometry being tailored to imaging the human brain. This project will be a partnership between researchers at the University of Manitoba and Cubresa, Inc., a medical device company based in Winnipeg. This collaboration builds on a previous successful effort in creating the Cubresa NuPET small animal PET insert system for hybrid PET/MRI that was based research conducted at the University of Manitoba. In this application, the technology behind the successful NuPET system will be scaled to be suitable for a human BrainPET system, leading to a clinical device capable of being used in any existing clinical MRI system.

正电子发射断层扫描（PET）与磁共振成像（MRI）的组合创造了强大的混合成像方式，这是由于PET敏感的分子成像能力与MRI的高质量解剖学，结缔组织和功能成像的协同作用。对于大脑的成像尤其如此，在这种情况下，两种模态的组合为理解和量化神经退行性疾病中大脑结构和功能变化的独特见解提供了独特的见解。不幸的是，由于当前可用的完全集成的PET/MRI系统的高资本成本，混合同时发生的PET/MRI仅在少数成像中心可用。此外，这些系统是为全身肿瘤学成像应用而设计的，因此不是大脑成像的理想选择。 我们建议开发一个可以改造为现有MRI的脑宠物成像系统，从而创造出同时执行PET/MRI神经成像的能力。与现有的全身宠物/MRI相比，Brainpet插入物将是低成本，同时，由于对人脑的成像量身定制了几何形状，因此提供了提高的空间分辨率和检测效率。该项目将是位于温尼伯的医疗设备公司的曼尼托巴大学和Cubresa，Inc。的研究人员之间的合作伙伴关系。这项合作以先前成功的努力为基础，用于创建基于在曼尼托巴大学进行的研究的Cubresa小动物宠物插入系统，用于混合宠物/MRI。在此应用程序中，成功的Nupet系统背后的技术将被缩放为适合人的Brainpet系统，从而导致能够在任何现有的临床MRI系统中使用的临床装置。