Technologies to advance hybrid multimodality positron emission tomography and magnetic resonance imaging

推进混合多模态正电子发射断层扫描和磁共振成像的技术

• 批准号: 341628-2012
• 负责人: Goertzen, Andrew
• 金额: $ 1.31万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=572325
• 关键词: Technologies; advance; hybrid; multimodality; positron

The practice of clinical nuclear medicine has been revolutionized in the past decade through the introduction of hybrid combined positron emission tomography (PET) with x-ray computed tomography (CT) and single photon emission computed tomography (SPECT) with CT. This highly synergistic combination of functional and anatomical imaging allows for improved diagnosis and staging of many diseases including cancer and Alzheimer's Disease. It is anticipated that the coming decade will see the widespread adoption of hybrid PET and SPECT with magnetic resonance imaging (MRI) due to the advantages of MRI over CT such as no radiation dose and exquisite soft tissue contrast. In this application we propose to develop technologies that will advance the capabilities of hybrid PET/MRI. Together with my students and post-doctoral fellows, I will construct compact, high resolution detectors for PET imaging, based on new silicon photomultiplier (SiPM) technology, that are MR compatible and will enable simultaneous PET/MRI imaging. We will create tools to facilitate the process of PET detector characterization, examine approaches to create low-cost imaging systems and implement high channel count electronics that will enable the construction of our prototype PET/MR system. These technologies will result in improved imaging system design for both clinical and pre-clinical imaging systems. These improvements in clinical imaging systems will benefit patient care through improved diagnostic accuracy of images and the improvements in preclinical animal imaging systems will allow for an improved understanding of animal models of human disease, reducing the time required to develop new therapeutics.

在过去的十年中，通过引入X射线计算机断层扫描（CT）和单个光子发射计算机断层扫描（SPECT），临床核医学的实践彻底改变了临床核医学。这种功能和解剖成像的高度协同组合允许改善许多疾病（包括癌症和阿尔茨海默氏病）的诊断和分期。预计未来十年将由于MRI优于CT（例如无辐射剂量和精美的软组织对比度）而广泛采用混合PET和具有磁共振成像（MRI）的SPECT。在此应用程序中，我们建议开发将提高混合宠物/MRI能力的技术。与我的学生和博士后研究员一起，我将基于新的硅光电培训（SIPM）技术来构建紧凑的高分辨率检测器，这些检测器是MR兼容的，并将启用同时的PET/MRI成像。我们将创建工具来促进宠物探测器表征的过程，检查创建低成本成像系统的方法，并实施高通道计数电子设备，从而能够构建我们的原型PET/MR系统。这些技术将为临床和临床前成像系统提供改进的成像系统设计。临床成像系统中的这些改进将通过提高图像的诊断准确性和临床前动物成像系统的改善而受益于患者护理，这将使人们对人类疾病动物模型的了解得以提高，从而减少开发新的治疗剂所需的时间。