High resolution positron emission tomography (PET) insert systems for multimodality PET/magnetic resonance imaging

用于多模态 PET/磁共振成像的高分辨率正电子发射断层扫描 (PET) 插入系统

• 批准号: RGPIN-2017-04963
• 负责人: Goertzen, Andrew
• 金额: $ 2.04万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=711318
• 关键词: resolution; positron; emission; tomography; PET

Positron emission tomography (PET) is an imaging modality that allows non-invasive assessment of tissue function at the molecular level in both clinical and preclinical settings through imaging the biodistribution of radioactively labelled tracers. The high specificity of many PET imaging tracers results in images with little anatomical information, making it difficult to assign the tracer uptake to specific tissues and complicating the interpretation and analysis of the images. The solution to this problem has been to integrate PET with an anatomical imaging modality, initially X-ray computed tomography (CT) and more recently, magnetic resonance (MR) imaging. Integration of PET with MR for preclinical hybrid PET/MR imaging of small animals can be efficiently accomplished through using a PET insert that fits within the bore of an existing high field MR system and can operate simultaneously with the MR. During the previous funding cycle, our group successfully developed and deployed such an insert for small animal PET/MR imaging using new MR compatible silicon photodetectors and a multi-layer scintillator array to preserve spatial resolution in the compact ring diameter PET system. PET insert systems for preclinical imaging are now becoming commercially available, including one based on our design commercialized through a Canadian company. In this application I will build on our expertise in PET insert systems for small animal PET/MR to achieve my long term objective of creating hardware and software technologies that enable the use of hybrid PET/MR imaging with PET inserts as a routine imaging modality in preclinical small animal research studies and in human neuroimaging application. To achieve this goal, the short term objectives of my research program detailed in this proposal cover three themes: i) algorithms and hardware to advance preclinical PET/MR imaging; ii) detector development for next generation PET insert systems; and iii) creating technologies to facilitate and automate small animal PET/MR imaging. These research objectives create multi-disciplinary training opportunities for graduate and undergraduate students from Electrical Engineering, Biomedical Engineering and Medical Physics. Close collaboration with both end users of imaging systems at the preclinical animal imaging and clinical imaging levels, together with industrial partners that manufacture imaging systems, facilitates rapid testing and deployment of new technologies, integration of user feedback for revisions and a path for technology translation of new devices.

正电子发射 断层扫描（PET）是一种成像方式，可无创评估组织 临床和临床前环境中分子水平的功能 通过成像放射性标记的示踪剂的生物分布。高 许多PET成像示踪剂的特异性导致图像很少有解剖学 信息，很难将示踪剂的吸收分配给特定 组织并使图像的解释和分析变得复杂。这 解决此问题的解决方案是将PET与解剖成像集成在一起 模式，最初是X射线计算机断层扫描（CT），最近，磁性 共振（MR）成像。将PET与MR集成用于临床前混合动力车 小动物的宠物/MR成像可以通过使用 适合现有高场MR系统孔的PET插入物和 可以与MR同时运行。在上一个资金周期中，我们 小组成功地开发并部署了小动物的插入物 使用新的MR兼容硅光电视和多层的PET/MR成像 闪烁体阵列以保持紧凑的环直径的空间分辨率 宠物系统。临床前成像的宠物插入系统现在已经成为 市售，包括基于我们通过商业化的设计 加拿大公司。 在此应用程序中，我将建立在我们的基础上 小动物宠物/MR的宠物插入系统专业知识，以实现我的长时间 创建硬件和软件技术的术语目标 启用与宠物插入物作为常规成像的混合宠物/MR成像 临床前小动物研究和人类神经影像学的模态 应用。为了实现这一目标，我的研究的短期目标 该提案中详细介绍的程序涵盖了三个主题：i）算法和硬件 推进临床前宠物/MR成像； ii）下一个检测器开发 一代宠物插入系统； iii）创建技术来促进和 自动化小动物宠物/MR成像。 这些研究目标创造了多学科 来自电气的研究生和本科生的培训机会 工程，生物医学工程和医学物理。密切合作 在临床前动物成像和 临床成像水平，以及生产的工业合作伙伴 成像系统，促进新技术的快速测试和部署，集成 用户反馈修订和新设备技术翻译的途径。