High resolution positron emission tomography (PET) insert systems for multimodality PET/magnetic resonance imaging

用于多模态 PET/磁共振成像的高分辨率正电子发射断层扫描 (PET) 插入系统

• 批准号: RGPIN-2017-04963
• 负责人: Goertzen, Andrew
• 金额: $ 2.04万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=682416
• 关键词: resolution; positron; emission; tomography; PET

Positron emission*tomography (PET) is an imaging modality that allows non-invasive assessment of tissue*function at the molecular level in both clinical and preclinical settings*through imaging the biodistribution of radioactively labelled tracers. The high*specificity of many PET imaging tracers results in images with little anatomical*information, making it difficult to assign the tracer uptake to specific*tissues and complicating the interpretation and analysis of the images. The*solution to this problem has been to integrate PET with an anatomical imaging*modality, initially X-ray computed tomography (CT) and more recently, magnetic*resonance (MR) imaging. Integration of PET with MR for preclinical hybrid*PET/MR imaging of small animals can be efficiently accomplished through using a*PET insert that fits within the bore of an existing high field MR system and*can operate simultaneously with the MR. During the previous funding cycle, our*group successfully developed and deployed such an insert for small animal*PET/MR imaging using new MR compatible silicon photodetectors and a multi-layer*scintillator array to preserve spatial resolution in the compact ring diameter*PET system. PET insert systems for preclinical imaging are now becoming*commercially available, including one based on our design commercialized through*a Canadian company.******In this application I will build on our*expertise in PET insert systems for small animal PET/MR to achieve my long*term objective of creating hardware and software technologies that*enable the use of hybrid PET/MR imaging with PET inserts as a routine imaging*modality in preclinical small animal research studies and in human neuroimaging*application. To achieve this goal, the short term objectives of my research*program detailed in this proposal cover three themes: i) algorithms and hardware*to advance preclinical PET/MR imaging; ii) detector development for next*generation PET insert systems; and iii) creating technologies to facilitate and*automate small animal PET/MR imaging.******These research objectives create multi-disciplinary*training opportunities for graduate and undergraduate students from Electrical*Engineering, Biomedical Engineering and Medical Physics. Close collaboration*with both end users of imaging systems at the preclinical animal imaging and*clinical imaging levels, together with industrial partners that manufacture*imaging systems, facilitates rapid testing and deployment of new technologies, integration*of user feedback for revisions and a path for technology translation of new devices.************

正电子发射*层析成像（PET）是一种成像方式，可以通过对放射性标记的示踪剂的生物分布进行成像，可以在临床和临床前环境中对组织*在分子水平上的功能进行非侵入性评估。许多PET成像示踪剂的高*特异性导致图像几乎没有解剖学*信息，因此很难将示踪剂的吸收分配给特定*组织，并使图像的解释和分析变得复杂。 *解决此问题的方法是将PET与解剖成像*模态，最初是X射线计算机断层扫描（CT），最近是磁共振（MR）成像。通过使用*PET插入物可以在现有的高场MR系统的孔内使用*PET插入物，可以有效地完成PET与MR进行临床前混合型促临床前杂种*PET/MR成像的整合。在上一个融资周期中，我们的*组成功开发并部署了用于小动物*PET/MR成像的插入物，并使用新的MR兼容硅光电视和多层*闪烁阵阵列来保留紧凑型环直径*PET系统中的空间分辨率。现在，用于临床前成像的宠物插入系统已成为商业上可用，包括基于我们通过*一家加拿大公司商业化的设计。神经成像*应用。为了实现这一目标，我的研究*计划的短期目标详细介绍了三个主题：i）算法和硬件*以推进临床前宠物/MR成像； ii）下一个*生成宠物插入系统的检测器开发； iii）创建技术来促进和*自动化小动物宠物/MR成像。与临床前动物成像和*临床成像水平的成像系统的最终用户的紧密合作*与生产*成像系统的工业合作伙伴一起，促进了新技术的快速测试和部署，用户反馈*修订的用户反馈和新设备技术翻译的道路。