PET Insert for Preclinical PET-MRI

用于临床前 PET-MRI 的 PET 插入物

• 批准号: 10188952
• 负责人: Christopher A Flask
• 金额: $ 41.29万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-15 至 2023-07-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10188952
• 关键词: 3-Dimensional; Advisory Committees; Alzheimer' s Disease; Area; Cardiovascular Diseases; Clinical Sciences; Comprehensive Cancer Center; Computer software; Cystic Fibrosis; Detection; Diabetes Mellitus; Digestive System Disorders; Faculty; Genes; Genetic Diseases; Goals; Healthcare; Image; Image Analysis; Immunology; Inflammation; Inflammatory Bowel Diseases; Institution; Licensing; Magnetic Resonance Imaging; Metabolism; Morphologic artifacts; Motion; Multiple Sclerosis; National Institute of Diabetes and Digestive and Kidney Diseases; Neurodegenerative Disorders; Patient Care; Performance; Physiologic Monitoring; Policies; Positron-Emission Tomography; Research; Research Personnel; Resolution; Signal Transduction; Stroke; System; Translational Research; Universities; cancer genetics; cost; experience; image visualization; imaging agent; imaging study; improved; metabolic imaging; molecular imaging; pre-clinical; programs; radio frequency; ranpirnase; respiratory; soft tissue; technology development

Project Summary We propose to purchase a new Cubresa MRI-Compatible PET insert to be combined with our existing 9.4T Bruker Biospec preclinical MRI scanner at Case Western Reserve University (CWRU). This new PET insert will create the first preclinical PET-MRI capability in Cleveland that will efficiently synergize our extensive preclinical PET and MRI imaging research programs to support 25 major users with research in the areas of PET and MRI technology developments, molecular imaging agents, new gene editing strategies, metabolism, inflammation, and immunology. With this new PET-MRI capability, these investigators will be able to combine the unmatched sensitivity of 3D PET imaging with the high spatial resolution and wide range of selectable soft tissue contrasts provided by MRI. The proposed system will also result in significantly reduced imaging costs and inherent 3D PET-MRI image co-registration in comparison to sequential PET-CT and MRI. The proposed system will also include: 1) PET- optimized radiofrequency coils enabling high-sensitivity MRI signal detection; 2) respiratory gating to limit motion artifacts; 3) multiple VivoQuant software licenses to provide efficient image visualization and analysis; and 4) physiologic monitoring and control capabilities necessary for effective metabolic imaging studies. These capabilities will broadly benefit an interdisciplinary group of investigators with the ultimate goal of improving health care for patients with cancer, genetic diseases including cystic fibrosis, inflammatory bowel disease, neurodegenerative diseases such as Alzheimer’s Disease and multiple sclerosis, cardiovascular disease, diabetes, and stroke. This new preclinical PET-MRI capability will be available to all regional investigators and will be operated by the Imaging Research Core at CWRU which is an integral component of multiple research centers at CWRU including the Case Comprehensive Cancer Center (NCI P30 CA043703), the Digestive Diseases Research Core Center (NIDDK P30 DK097948), the Clinical and Translational Science Collaborative (NCATS UL1 TR002548), and the Cystic Fibrosis Research Center. This ongoing support for the Imaging Research Core is in addition to the direct institutional support of $100,000 to partially offset the cost for this new PET imaging insert. An advisory committee with highly experienced PET and MRI faculty at CWRU and external institutions will oversee the organization and usage of the system and recommend policies to maintain system performance and maximize utilization.

项目概要 我们建议购买新的 Cubresa MRI 兼容 PET 插入件，以便与我们的 凯斯西储大学现有 9.4T Bruker Biospec 临床前 MRI 扫描仪 (CWRU)。这种新的 PET 插入将在克利夫兰创建第一个临床前 PET-MRI 功能。 将有效地协同我们广泛的临床前 PET 和 MRI 成像研究项目， 支持 25 个主要用户进行 PET 和 MRI 技术开发领域的研究， 分子成像剂、新的基因编辑策略、代谢、炎症和 借助这种新的 PET-MRI 功能，这些研究人员将能够将免疫学结合起来。 3D PET 成像无与伦比的灵敏度、高空间分辨率和宽范围 所提出的系统还将产生由 MRI 提供的可选择的软组织对比度。 降低成像成本并显着提高固有的 3D PET-MRI 图像共同配准 与连续 PET-CT 和 MRI 的比较 所提出的系统还将包括： 1) PET- 优化的射频线圈可实现高灵敏度 MRI 信号检测 2) 呼吸门控； 限制运动伪影；3) 多个 VivoQuant 软件许可证以提供高效的图像 可视化和分析；4) 必要的生理监测和控制能力 有效的代谢成像研究将广泛受益于跨学科。 一组研究人员的最终目标是改善癌症患者的医疗保健， 遗传性疾病，包括囊性纤维化、炎症性肠病、神经退行性疾病 阿尔茨海默病和多发性硬化症、心血管疾病、糖尿病等疾病， 这种新的临床前 PET-MRI 功能将可供所有区域研究人员使用。 并将由 CWRU 的影像研究核心运营，该核心是 CWRU 的多个研究中心，包括凯斯综合癌症中心 (NCI P30 CA043703），消化疾病研究核心中心（NIDDK P30 DK097948），临床 和转化科学合作组织 (NCATS UL1 TR002548) 和囊性纤维化 研究中心对成像研究核心的持续支持是对直接支持的补充。 100,000 美元的机构支持可部分抵消这种新 PET 成像插入的成本。 咨询委员会由 CWRU 和外部经验丰富的 PET 和 MRI 教员组成 机构将监督该系统的组织和使用，并提出政策建议 保持系统性能并最大限度地提高利用率。